OCT2Former: A retinal OCT-angiography vessel segmentation transformer

Computer Methods and Programs in Biomedicine, Journal Year: 2023, Volume and Issue: 233, P. 107454 - 107454

Published: March 5, 2023

Language: Английский

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Optical coherence tomography angiography of the retina and choroid in systemic diseases

Progress in Retinal and Eye Research, Journal Year: 2024, Volume and Issue: 103, P. 101292 - 101292

Published: Aug. 30, 2024

Optical coherence tomography angiography (OCTA) has transformed ocular vascular imaging, revealing microvascular changes linked to various systemic diseases. This review explores its applications in diabetes, hypertension, cardiovascular diseases, and neurodegenerative While OCTA provides a valuable window into the body's microvasculature, interpreting findings can be complex. Additionally, challenges exist due relative non-specificity of where observed might not unique specific disease, variations between machines, lack standardized normative database for comparison, potential image artifacts. Despite these limitations, holds immense future. The highlights promising advancements like quantitative analysis images, integration artificial intelligence faster more accurate interpretation, multi-modal imaging combining with other techniques comprehensive characterization vasculature. Furthermore, OCTA's future role personalized medicine, enabling tailored treatment plans based on individual findings, community screening programs early disease detection, longitudinal studies tracking progression over time is also discussed. In conclusion, presents significant opportunity improve our understanding management Addressing current limitations pursuing exciting directions solidify as an indispensable tool diagnosis, monitoring progression, potentially guiding decisions across health conditions.

Language: Английский

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In Vivo Imaging of Retinal and Choroidal Morphology and Vascular Plexuses of Vertebrates Using Swept-Source Optical Coherence Tomography

Translational Vision Science & Technology, Journal Year: 2022, Volume and Issue: 11(8), P. 11 - 11

Published: Aug. 16, 2022

Purpose: To perform in vivo evaluation of the structural morphology and vascular plexuses neurosensory retina choroid across vertebrate species using swept-source optical coherence tomography (SS-OCT) SS-OCT angiography (SS-OCTA) imaging. Methods: A custom-built system with an incorporated flexible imaging arm was used to acquire three-dimensional (3D) retinal OCT OCTA data five different vertebrates: a mouse (C57BL/6J), rat (Long Evans), gray short-tailed opossum (Monodelphis domestica), white sturgeon (Acipenser transmontanus), great horned owl (Bubo virginianus). Results: In choroid, as well en face images choroidal vasculature all were generated. The similar between mouse, whereas distinct paired superficial vessels observed retina. structure sturgeon, pecten oculi overlying avascular are reported vivo. Conclusions: high-quality two-dimensional 3D visualization structures plexus vertebrates possible. Our studies affirm that SS-OCTA viable methods for evaluating terrestrial, aquatic, aerial vertebrates. Translational Relevance: characterization multiple can increase pool available models human diseases.

Language: Английский

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An open-source deep learning network AVA-Net for arterial-venous area segmentation in optical coherence tomography angiography

Communications Medicine, Journal Year: 2023, Volume and Issue: 3(1)

Published: April 17, 2023

Differential artery-vein (AV) analysis in optical coherence tomography angiography (OCTA) holds promise for the early detection of eye diseases. However, currently available methods AV are limited binary processing retinal vasculature OCTA, without quantitative information vascular perfusion intensity. This study is to develop and validate a method

Language: Английский

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In vivo corneal elastography: A topical review of challenges and opportunities

Computational and Structural Biotechnology Journal, Journal Year: 2023, Volume and Issue: 21, P. 2664 - 2687

Published: Jan. 1, 2023

Clinical measurement of corneal biomechanics can aid in the early diagnosis, progression tracking, and treatment evaluation ocular diseases. Over past two decades, interdisciplinary collaborations between investigators optical engineering, analytical biomechanical modeling, clinical research has expanded our knowledge biomechanics. These advances have led to innovations testing methods (

Language: Английский

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A Systematic Investigation of Image Pre-Processing on Image Classification

IEEE Access, Journal Year: 2024, Volume and Issue: 12, P. 64913 - 64926

Published: Jan. 1, 2024

AI-powered image analysis is a transformative technology with immense potential to enhance diagnostics and patient care. Accurate medical assessment plays crucial role in disease detection treatment planning, yet challenges arise due noise visual variations imaging. Image pre-processing key solution address these challenges, while widely used, there lack of studies on its effectiveness. Recognizing this gap, our research aims contribute insights scientific scope. This specifically delves into the impact binary classification model performance, rather than hyperparameter optimization. We deliberately selected limited comprehensive subset methods datasets; H&E-stained tissue, chest X-ray, retina OCT images were chosen ensure generalizability findings. Analysis revealed that implementing significantly improved mean sensitivity models: from 0.87 0.97 for 0.92 0.96 X-rays, 0.99 Retina images. Two different sequences applying steps explored, minimal effect observed altered sequences, indicating consistent improvement regardless sequence. investigated employed 40 best-performing worst-performing models, determined by higher lower sensitivities. have uncovered models displayed only similarities, except pooling mode. observation also applied sensitivity.

Language: Английский

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Optical Coherence Tomography Angiography (OCTA) of the eye: A review on basic principles, advantages, disadvantages and device specifications

Clinical Hemorheology and Microcirculation, Journal Year: 2022, Volume and Issue: 83(3), P. 247 - 271

Published: Dec. 6, 2022

Optical Coherence Tomography Angiography (OCTA) is a relatively new imaging technique in ophthalmology for the visualization of retinal microcirculation and other tissues human eye. This review paper aims to describe basic definitions principles OCT OCTA most straightforward possible language without complex mathematical engineering analysis. done help health professionals various disciplines improve their understanding design further clinical research more efficiently. First, technical related terminology are described. Then, list advantages disadvantages, with special reference blood flow quantification limitations. Finally, an updated hardware software specifications some commercially available devices presented.

Language: Английский

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The role of the retinal vasculature in age-related macular degeneration: a spotlight on OCTA

Eye, Journal Year: 2023, Volume and Issue: 38(3), P. 442 - 449

Published: Sept. 6, 2023

Abstract Age-related macular degeneration (AMD) remains a disease with high morbidity and an incompletely understood pathophysiological mechanism. The ocular blood supply has been implicated in the development of process, which most research focused on role choroid choriocapillaris. Recently, interest developed into retinal vasculature AMD, particularly advent optical coherence tomography angiography (OCTA), enables non-invasive imaging eye’s vessels. This review summarises up-to-date body work this field including proposed links between observed changes vessels AMD potential future directions for area. highlights that strongest evidence supports observation patients early to intermediate have reduced vessel density superficial vascular complex retina, but also emphasises need caution when interpreting such studies due their variable methodologies nomenclature.

Language: Английский

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Towards standardising retinal OCT angiography image analysis with open-source toolbox OCTAVA

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: March 12, 2024

Quantitative assessment of retinal microvasculature in optical coherence tomography angiography (OCTA) images is important for studying, diagnosing, monitoring, and guiding the treatment ocular systemic diseases. However, OCTA user community lacks universal transparent image analysis tools that can be applied to from a range instruments provide reliable consistent microvascular metrics diverse datasets. We present extension Vascular Analyser (OCTAVA) addresses challenges providing robust, easy-to-use, images. OCTAVA user-friendly, open-source toolbox analyse various instruments. The delivers seven whole or subregions six characterising foveal avascular zone. validate using collected by four commercial demonstrating robust performance across datasets different acquired at sites study cohorts. show values comparable literature reduces their variation between studies compared equivalents. By making publicly available, we aim expand standardised research thereby improve reproducibility quantitative imaging. Such improvements will help better identify more sensitive biomarkers

Language: Английский

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Shedding light on ultrasound in action: Optical and optoacoustic monitoring of ultrasound brain interventions

Advanced Drug Delivery Reviews, Journal Year: 2024, Volume and Issue: 205, P. 115177 - 115177

Published: Jan. 5, 2024

Monitoring brain responses to ultrasonic interventions is becoming an important pillar of a growing number applications employing acoustic waves actuate and cure the brain. Optical interrogation living tissues provides unique means for retrieving functional molecular information related activity disease-specific biomarkers. The hybrid optoacoustic imaging methods have further enabled deep-tissue with optical contrast at high spatial temporal resolution. marriage between light sound thus brings together highly complementary advantages both modalities toward precision interrogation, stimulation, therapy strong impact in fields ultrasound neuromodulation, gene drug delivery, or noninvasive treatments neurological neurodegenerative disorders. In this review, we elaborate on current advances monitoring interventions. We describe main principles mechanisms underlying each method before diving into corresponding biomedical applications. identify areas improvement as well promising approaches clinical translation potential.

Language: Английский

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