Optics Express,
Journal Year:
2024,
Volume and Issue:
32(12), P. 21795 - 21795
Published: May 23, 2024
Due
to
the
high
cost,
low-performance
lasers
and
detectors
in
mid-infrared
(MIR)
band,
development
of
MIR-integrated
devices
is
very
slow.
Here,
we
demonstrate
an
effective
method
characterize
parameters
MIR
by
using
frequency
conversion
technology.
We
designed
fabricated
rib
waveguides
micro-ring
resonators
(MRRs)
on
a
silicon-on-sapphire
platform.
The
laser
for
test
generated
difference
generation,
transmission
spectrum
MIR-MRRs
detected
sum
generation.
experimental
results
show
that
waveguide
loss
4.5
dB/cm
quality
factor
reaches
38000,
which
good
agreement
with
numerical
simulations.
This
work
provides
useful
integrated
based
technique,
can
boost
optics
future.
Nature Communications,
Journal Year:
2024,
Volume and Issue:
15(1)
Published: Jan. 8, 2024
Abstract
Understanding
metabolic
heterogeneity
is
the
key
to
uncovering
underlying
mechanisms
of
metabolic-related
diseases.
Current
imaging
studies
suffer
from
limitations
including
low
resolution
and
specificity,
model
systems
utilized
often
lack
human
relevance.
Here,
we
present
a
single-cell
platform
enable
direct
lipid
metabolism
with
high
specificity
in
various
human-derived
2D
3D
culture
systems.
Through
incorporation
an
azide-tagged
infrared
probe,
selective
detection
newly
synthesized
lipids
cells
tissue
became
possible,
while
simultaneous
fluorescence
enabled
cell-type
identification
complex
tissues.
In
proof-of-concept
experiments,
were
directly
visualized
human-relevant
among
different
cell
types,
mutation
status,
differentiation
stages,
over
time.
We
identified
upregulated
progranulin-knockdown
induced
pluripotent
stem
their
differentiated
microglia
cells.
Furthermore,
observed
that
neurons
brain
organoids
exhibited
significantly
lower
compared
astrocytes.
Smart Medicine,
Journal Year:
2023,
Volume and Issue:
2(4)
Published: Nov. 1, 2023
Abstract
Circulating
tumor
DNA
(ctDNA)
is
naked
molecules
shed
from
the
cells
into
peripheral
blood
circulation.
They
contain
tumor‐specific
gene
mutations
and
other
valuable
information.
ctDNA
considered
to
be
one
of
most
significant
analytes
in
liquid
biopsies.
Over
past
decades,
numerous
researchers
have
developed
various
detection
strategies
perform
quantitative
or
qualitative
analysis,
including
PCR‐based
sequencing‐based
detection.
More
more
studies
illustrated
great
value
as
a
biomarker
diagnosis,
prognosis
heterogeneity
tumor.
In
this
review,
we
first
outlined
development
digital
PCR
(dPCR)‐based
next
generation
sequencing
(NGS)‐based
systems.
Besides,
presented
introduction
emerging
analysis
based
on
biosensors,
such
electrochemical
fluorescent
surface
plasmon
resonance
Raman
spectroscopy,
well
their
applications
field
biomedicine.
Finally,
summarized
essentials
preceding
discussions,
existing
challenges
prospects
for
future
are
also
involved.
Journal of the American Chemical Society,
Journal Year:
2024,
Volume and Issue:
146(3), P. 2187 - 2195
Published: Jan. 12, 2024
In
recent
years,
optical
pump–probe
microscopy
(PPM)
has
become
a
vital
technique
for
spatiotemporally
imaging
electronic
excitations
and
charge-carrier
transport
in
metals
semiconductors.
However,
existing
methods
are
limited
by
mechanical
delay
lines
with
probe
time
window
up
to
several
nanoseconds
(ns)
or
monochromatic
pump
sources
restricted
spectral
coverage
temporal
resolution,
hindering
their
amenability
studying
relatively
slow
processes.
To
bridge
these
gaps,
we
introduce
dual-hyperspectral
PPM
setup
spanning
from
milliseconds
single-nanosecond
resolution.
Our
method
features
wide-field
tunable
370
1000
nm
330
16
μm.
We
apply
this
study
various
two-dimensional
metal-halide
perovskites
(2D-MHPs)
as
representative
semiconductors
transient
responses
near
the
exciton
resonances
under
both
above-band
gap
excitation
below-band
vibrational
excitation.
The
resulting
spatially
temporally
resolved
images
reveal
insights
into
heat
dissipation,
film
uniformity,
distribution
of
impurity
phases,
film–substrate
interfaces.
addition,
resolution
enables
in-plane
strain
wave
propagation
2D-MHP
single
crystals.
method,
which
offers
extensive
tunability
significantly
improved
opens
new
possibilities
charge
carriers,
heat,
phase
transformation
processes,
particularly
materials
varying
composition,
strain,
crystalline
structure,
Optics Continuum,
Journal Year:
2024,
Volume and Issue:
3(10), P. 1918 - 1918
Published: Aug. 27, 2024
We
report
the
development
of
a
new
multimodal
nonlinear
microscopy
platform
for
material
and
life
sciences.
The
laser
scanning
microscope
is
capable
hyperspectral
imaging
by
coherent
Raman
scattering
using
either
spectral
focusing
technique
or
femtosecond
pulses.
Other
optical
signals
normal
confocal
fluorescence
can
also
be
detected.
It
highly
adaptable
fully
motorised
system
with
specific
calibration
procedures
equipped
simple
graphical
user
interface
experiment
control
data
analysis.
description
characterisation
instrument
along
an
application
example
pharmaceutical
tablet
image.
results
underline
current
state-of-the-art
such
instrument.
APL Photonics,
Journal Year:
2024,
Volume and Issue:
9(10)
Published: Oct. 1, 2024
Mid-infrared
microscopy
is
an
important
tool
for
biological
analyses,
allowing
a
direct
probe
of
molecular
bonds
in
their
low
energy
landscape.
In
addition
to
the
label-free
extraction
spectroscopic
information,
application
broadband
sources
can
provide
third
dimension
chemical
specificity.
However,
enable
widespread
deployment,
mid-infrared
platforms
need
be
compact
and
robust
while
offering
high
speed,
broad
bandwidth,
signal-to-noise
ratio.
this
study,
we
experimentally
showcase
integration
broadband,
high-repetition-rate
dual-comb
spectrometer
(DCS)
range
with
scanning
microscope.
We
employ
set
1-GHz
frequency
combs,
demonstrating
capability
high-speed
hyperspectral
imaging
polymers
ovarian
tissue.
The
system
covers
1000
cm−1
at
νc
=
2941
12.86
kHz
spectra
acquisition
rate
5
µm
spatial
resolution.
Taken
together,
our
experiments
analysis
elucidate
trade-off
between
bandwidth
speed
DCS
as
it
relates
microscopy.
This
provides
roadmap
future
advancement
imaging.
Photonics Research,
Journal Year:
2024,
Volume and Issue:
12(8), P. 1593 - 1593
Published: May 9, 2024
A
spectral
programmable,
continuous-wave
mid-infrared
(MIR)
optical
parametric
oscillator
(OPO),
enabled
by
a
self-developed
high-power
tailorable
fiber
laser,
was
proposed
and
realized.
While
operating
at
single-wavelength,
the
maximum
idler
power
reached
5.53
W
3028
nm,
with
corresponding
pump-to-idler
conversion
efficiency
of
14.7%.
The
wavelength
number
switchable
output
available
from
one
to
three.
single
tunable
in
range
528
nm
(2852–3380
nm).
In
dual-wavelength
operation,
interval
between
two
idlers
could
be
flexibly
tuned
for
470
(53–523
nm),
intensity
each
channel
controllable.
Triple-wavelength
emission
realized,
meanwhile
exhibiting
custom-tailored
characteristics.
Furthermore,
we
balanced
gain
through
pre-modulating
broadband
multi-peak
pump
spectra,
enabling
10
dB
bandwidth
adjustment
20
125
nm.
This
versatile
simultaneously
featuring
wide
tuning,
multi-wavelength
broad
manipulation,
has
great
application
potential
composition
detection,
terahertz
generation,
speckle-free
imaging.
