Precise HER2 Protein Degradation via Peptide‐Conjugated Photodynamic Therapy for Enhanced Breast Cancer Immunotherapy DOI Creative Commons
Changyong Guo, Fei Gao, Guoyuan Wu

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: 12(2)

Published: Nov. 18, 2024

Abstract Breast cancer, the most prevalent malignancy among women, frequently exhibits high HER2 expression, making a critical therapeutic target. Traditional treatments combining anti‐HER2 antibody trastuzumab with immunotherapy face limitations due to toxicity and tumor microenvironment immunosuppression. This study introduces an innovative strategy HER2‐targeting peptides photosensitizer (PSs) pyropheophorbide‐a (Pha) via gelatinase‐cleavable linker, forming self‐assembling nanoparticles. These nanoparticles actively target breast cancer cells generate reactive oxygen species (ROS) under near‐infrared light, effectively degrading proteins. Upon internalization, linker is cleaved, releasing Pha‐PLG enhancing intracellular photodynamic therapy (PDT). The molecules self‐assemble into nanofibers, prolonging circulation, boosting immune induction, activating CD8 + T cells, thus promoting robust anti‐tumor response. In vivo, studies confirm superior biosafety, targeting, degradation, increased cytotoxic cell activity improved antitumor immunity. integrated offers promising new avenue for treatment.

Language: Английский

Hydrogen‐Bonded Organic Framework Nanoscintillators for X‐Ray‐Induced Photodynamic Therapy in Hepatocellular Carcinoma DOI Open Access

Lihui Gu,

Han Wu, Xu Li

et al.

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 10, 2025

Abstract X‐ray induced photodynamic therapy (X‐PDT) leverages penetrating to generate singlet oxygen ( 1 O 2 ) for treating deep‐seated tumors. However, conventional X‐PDT typically relies on heavy metal inorganic scintillators and organic photosensitizers produce , which presents challenges related toxicity energy conversion efficiency. In this study, highly biocompatible phosphorescent nanoscintillators based hydrogen‐bonded frameworks (HOF) are designed engineered, termed BPT‐HOF@PEG, enhance in hepatocellular carcinoma (HCC) treatment. BPT‐HOF@PEG functions simultaneously as both scintillator photosensitizer, effectively absorbing transferring abundant . Both vitro vivo investigations demonstrate that internalized efficiently produces significant quantities of upon irradiation. Additionally, exposure directly inflicts DNA damage, the synergistic effects these mechanisms result pronounced cell death substantial tumor growth inhibition, with a inhibition rate up 90.4% assessments. RNA sequencing analyses reveal induces apoptosis Hepa1‐6 cells while inhibiting proliferation, culminating death. Therefore, work highlights considerable potential efficient HOF nanoscintillators‐based promising therapeutic approach HCC, providing effective alternative negligible patients unresectable

Language: Английский

Citations

1
Dimerized Pentamethine Cyanines for Synergistically Boosting Photodynamic/Photothermal Therapy DOI Creative Commons

Haiqiao Huang,

Qiang Liu, Jinghui Zhu

et al.

Aggregate, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 18, 2024

ABSTRACT Photodynamic therapy (PDT) and photothermal (PTT) have emerged promising applications in both fundamental research clinical trials. However, it remains challenging to develop ideal photosensitizers (PSs) that concurrently integrate high photostability, large near‐infrared absorptivity, efficient therapeutic capabilities. Herein, we reported a sample engineering strategy afford benzene‐fused Cy5 dimer ( Cy‐D‐5 ) for synergistically boosting PDT/PTT applications. Intriguingly, exhibits tendency form J ‐aggregates H phosphate‐buffered saline, which show long‐wavelength absorption band bathochromically shifted 810 nm short‐wavelength hypsochromically 745 nm, respectively, when compared its behavior ethanol (778 nm). Density‐functional theory calculations combined with time‐resolved transient optical spectroscopy analysis reveal the fused low Δ E ST (0.51 eV) non‐radiative transition rates (12.6 times greater than of clinically approved PS‐indocyanine green [PS‐ ICG ]). Furthermore, demonstrates higher photosensitizing ability produce 1 O 2 , stronger conversion efficiency η = 64.4%), photostability . These properties enable achieve complete tumor ablation upon 808 laser irradiation, highlighting potential as powerful dual‐function phototherapeutic agent. This work may offer practical other existing dyes red‐shifted spectral range various phototherapy

Language: Английский

Citations

5
Implantable, flexible biophotonic device for wireless photodynamic therapy of postoperative infection and tumor recurrence DOI Creative Commons
Jianhong Zhang,

Renhao Nie,

Qingyan Jia

et al.

Device, Journal Year: 2025, Volume and Issue: unknown, P. 100754 - 100754

Published: March 1, 2025

Language: Английский

Citations

0
Possible integration of artificial intelligence with photodynamic therapy and diagnosis: A review DOI Creative Commons
Nkune Williams Nkune, Heidi Abrahamse

Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: 101, P. 106210 - 106210

Published: Sept. 16, 2024

Language: Английский

Citations

3
Precise HER2 Protein Degradation via Peptide‐Conjugated Photodynamic Therapy for Enhanced Breast Cancer Immunotherapy DOI Creative Commons
Changyong Guo, Fei Gao, Guoyuan Wu

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: 12(2)

Published: Nov. 18, 2024

Abstract Breast cancer, the most prevalent malignancy among women, frequently exhibits high HER2 expression, making a critical therapeutic target. Traditional treatments combining anti‐HER2 antibody trastuzumab with immunotherapy face limitations due to toxicity and tumor microenvironment immunosuppression. This study introduces an innovative strategy HER2‐targeting peptides photosensitizer (PSs) pyropheophorbide‐a (Pha) via gelatinase‐cleavable linker, forming self‐assembling nanoparticles. These nanoparticles actively target breast cancer cells generate reactive oxygen species (ROS) under near‐infrared light, effectively degrading proteins. Upon internalization, linker is cleaved, releasing Pha‐PLG enhancing intracellular photodynamic therapy (PDT). The molecules self‐assemble into nanofibers, prolonging circulation, boosting immune induction, activating CD8 + T cells, thus promoting robust anti‐tumor response. In vivo, studies confirm superior biosafety, targeting, degradation, increased cytotoxic cell activity improved antitumor immunity. integrated offers promising new avenue for treatment.

Language: Английский

Citations

2