Acid-Unlocked Two-Layer Ca-Loaded Nanoplatform to Interfere With Mitochondria for Synergistic Tumor Therapy

International Journal of Nanomedicine, Journal Year: 2025, Volume and Issue: Volume 20, P. 1899 - 1920

Published: Feb. 1, 2025

Background: The development of selective formulations able to target and kill tumor cells without the application external energy has shown great promise for anti-tumor therapy. Methods: Here, we report a "nanobomb" that explosively increases Ca content within cells. It can selectively release 2+ generate H 2 O in microenvironment (TME) by acid-triggered degradation two-layer protective shell (ie, unlocking "double-lock"). This material, termed CaO @ZIF8:CUR@PAA, comprises core coated with ZIF-8 framework, which was then loaded curcumin (CUR) again polyacrylic acid (PAA). Results: Under slightly acidic conditions TME, PAA (first lock) breaks down first exposing @ZIF8 CUR inside cell. Then, ZIF8 (second is degraded response deposit , . promote from endoplasmic reticulum cytoplasm, inhibit outflow accumulates large amount intracellularly together exogenous (calcium storms). powerful calcium storm causes mitochondrial dysfunction. presence further oxidative damage cell membranes mitochondria where intracellular ROS production far exceeds clearance. @ZIF8:CUR@PAA NPs induce S cycle arrest apoptosis multiplication growth. Oxidative damage-triggered immunogenic death (ICD) turn leads polarization macrophages M1 phenotype, inducing inhibiting proliferation metastasis. Discussion: two-step nanoplatform therapeutic modality combines damage. mode triggers leading ICD material induces blockade during treatment proliferation. Robust vitro vivo data demonstrate efficacy this approach as an anticancer platform, paving way nanomaterials immune-triggered cancer Highlights: - A new accumulation plays role activate antitumor immunity.- Double-locked structure slows premature decomposition .- platform allows accumulate cells.- dysfunction, apoptosis, macrophage polarization.- Potent effects are seen both vivo. Keywords: Calcium ion load, controlled-release nanomaterials, shell, pH responsive drug release, reactive oxygen species, anti-cancer

Language: Английский

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Chiral Inorganic Nanomaterial‐Based Diagnosis and Treatments for Neurodegenerative Diseases

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 9, 2025

Chiral nanomaterials are widely investigated over recent decades due to their biocompatibility and unique chiral effects. These key properties have significantly promoted the rapid development of in bioengineering medicine. In this review, basic principles constructing along with latest progress research comprehensively summarized. Then, application for diagnosis neurodegenerative diseases (NDDs) is systematically described. addition, significant potential broad prospects treatment NDDs highlighted from several aspects, including disaggregation neurofibrils, scavenging reactive oxygen species, regulation microbial-gut-brain axis, elimination senescent cells, promotion directed differentiation neural stem cells. Finally, a perspective challenges future provided.

Language: Английский

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NIR-Activated Hollow Upconversion Nanocomposites for Tumor Therapy via GLUT1 Inhibition and Mitochondrial Function Disruption

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Tumor remains a leading contributor to global mortality rates, necessitating urgent advancements in therapeutic interventions. Due the intricate nature of tumor microenvironment, individual differences make it difficult achieve desired efficacy with single strategy. To overcome these challenges, we develop for first time hollow NaBiF4-based nanocomposites NaBiF4-W/R-D therapy by glucose transporter 1 (GLUT1) inhibition and mitochondrial function disruption. can inhibit GLUT1 due presence WZB117, which leads decrease intracellular cells, leaving them starved state. Meanwhile, upconversion luminescence under near-infrared (NIR) laser irradiation stimulate photosensitizer efficiently generate singlet oxygen disrupt then kill cells. In addition, NIR-II emission from is used fluorescence imaging determine optimal point treatment. Finally, membrane potential depolarization, impaired function, activation caspase-3, ultimately amplification apoptosis.

Language: Английский

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Dynamic Electro‐Fluorochromic Device Based on Aggregation‐Induced Emission Carbon Dots and Prussian Blue for Anti‐Counterfeiting

Advanced Optical Materials, Journal Year: 2025, Volume and Issue: unknown

Published: May 19, 2025

Abstract Electro‐fluorochromic (EFC) dual‐functional materials have attracted remarkable attention due to their feature about two distinct display modes. Carbon dots (CDs) stand out as a tunable photoluminescent materials. The pursuit of tunability controlled by electricity in dynamic devices remains challenging goal. In this study, an EFC material is developed based on electrochromic (EC) Prussian blue (PB) and aggregation‐induced emission CDs, utilizing energy transfer mechanism achieve synergistic modulation. CDs/PB film exhibited reversible optical responses while maintaining excellent EC performance PB with stable cycling over 2000 cycles fast response speed. This shows promising potential for advanced technologies, interactive interfaces, anticounterfeiting applications. These findings provide valuable strategy the development multifunctional sensors.

Language: Английский

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Extending visual range of bacteria with upconversion nanoparticles and constructing NIR-responsive bio-microrobots

Journal of Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 682, P. 608 - 618

Published: Dec. 1, 2024

Language: Английский

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