Soft wearable devices for deep-tissue sensing

Nature Reviews Materials, Journal Year: 2022, Volume and Issue: 7(11), P. 850 - 869

Published: March 14, 2022

Language: Английский

---

Ultra‐Thin Flexible Encapsulating Materials for Soft Bio‐Integrated Electronics

Advanced Science, Journal Year: 2022, Volume and Issue: 9(30)

Published: Aug. 28, 2022

Abstract Recently, bioelectronic devices extensively researched and developed through the convergence of flexible biocompatible materials electronics design that enables more precise diagnostics therapeutics in human health care opens up potential to expand into various fields, such as clinical medicine biomedical research. To establish an accurate stable bidirectional bio‐interface, protection against external environment high mechanical deformation is essential for wearable devices. In case implantable bioelectronics, special encapsulation optimized designs configurations provide electronic stability functionality are required accommodating organ properties, lifespans, functions biofluid environment. Here, this study introduces recent developments ultra‐thin encapsulations with novel can preserve or even improve electrical performance bio‐integrated by supporting safety from destruction contamination well optimizing use systems physiological environments. addition, a summary materials, methods, characteristics most widely used technologies introduced, thereby providing strategic selection appropriate choices recently bioelectronics.

Language: Английский

---

A wireless and battery-less implant for multimodal closed-loop neuromodulation in small animals

Nature Biomedical Engineering, Journal Year: 2023, Volume and Issue: 7(10), P. 1252 - 1269

Published: April 27, 2023

Language: Английский

---

Advances in Triboelectric Nanogenerators for Self‐powered Neuromodulation

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 33(8)

Published: Jan. 10, 2023

Abstract Advances in implantable bioelectronics for the nervous system are reinventing stimulation, inhibition, and sensing of neuronal activity. These efforts promise not just breakthrough treatments several neurological psychiatric conditions but also signal beginning a new era computer‐controlled human therapeutics. Batteries remain major power source all implanted electrical neuromodulation devices, which impairs miniaturization necessitates replacement surgery when battery is drained. Triboelectric nanogenerators (TENGs) have recently emerged as an innovative solution self‐powered, closed loop neurostimulation devices. TENGs can leverage biomechanical activities different body organs to sustainably generate electricity neurostimulation. This review features advances they pave way self‐sustainable A comprehensive TENG research brain, autonomic, somatic systems provided. The direction growth this field, publication trends, modes discussed. Finally, insightful outlook into challenges facing neuromodulators reach clinical practice provided, solutions maladies proposed.

Language: Английский

---

Bioelectronics for electrical stimulation: materials, devices and biomedical applications

Chemical Society Reviews, Journal Year: 2024, Volume and Issue: 53(17), P. 8632 - 8712

Published: Jan. 1, 2024

Bioelectronics is a hot research topic, yet an important tool, as it facilitates the creation of advanced medical devices that interact with biological systems to effectively diagnose, monitor and treat broad spectrum health conditions. Electrical stimulation (ES) pivotal technique in bioelectronics, offering precise, non-pharmacological means modulate control processes across molecular, cellular, tissue, organ levels. This method holds potential restore or enhance physiological functions compromised by diseases injuries integrating sophisticated electrical signals, device interfaces, designs tailored specific mechanisms. review explains mechanisms which ES influences cellular behaviors, introduces essential principles, discusses performance requirements for optimal systems, highlights representative applications. From this review, we can realize based bioelectronics therapy, regenerative medicine rehabilitation engineering technologies, ranging from tissue neurological modulation cardiovascular cognitive functions. underscores versatility various biomedical contexts emphasizes need adapt complex clinical landscapes addresses.

Language: Английский

---

Wireless Battery-free and Fully Implantable Organ Interfaces

Chemical Reviews, Journal Year: 2024, Volume and Issue: 124(5), P. 2205 - 2280

Published: Feb. 21, 2024

Advances in soft materials, miniaturized electronics, sensors, stimulators, radios, and battery-free power supplies are resulting a new generation of fully implantable organ interfaces that leverage volumetric reduction mechanics by eliminating electrochemical storage. This device class offers the ability to provide high-fidelity readouts physiological processes, enables stimulation, allows control over organs realize therapeutic diagnostic paradigms. Driven seamless integration with connected infrastructure, these devices enable personalized digital medicine. Key advances carefully designed material, electrophysical, electrochemical, electromagnetic systems form implantables mechanical properties closely matched target deliver functionality supports sensors stimulators. The elimination operation, anywhere from acute, lifetimes matching subject physical dimensions imperceptible operation. review provides comprehensive overview basic building blocks related topics such as implantation, delivery, sterilization, user acceptance. State art examples categorized system an outlook interconnection advanced strategies for computation leveraging consistent influx elevate this current battery-powered is highlighted.

Language: Английский

---

Miniaturized Implantable Fluorescence Probes Integrated with Metal–Organic Frameworks for Deep Brain Dopamine Sensing

ACS Nano, Journal Year: 2024, Volume and Issue: 18(15), P. 10596 - 10608

Published: April 1, 2024

Continuously monitoring neurotransmitter dynamics can offer profound insights into neural mechanisms and the etiology of neurological diseases. Here, we present a miniaturized implantable fluorescence probe integrated with metal-organic frameworks (MOFs) for deep brain dopamine sensing. The is assembled from physically thinned light-emitting diodes (LEDs) phototransistors, along functional surface coatings, resulting in total thickness 120 μm. A fluorescent MOF that specifically binds introduced, enabling highly sensitive measurement detection limit 79.9 nM. compact wireless circuit weighing only 0.85 g also developed interfaced probe, which was later applied to continuously monitor real-time levels during stimulation rats, providing critical information on dynamics. Cytotoxicity tests immunofluorescence analysis further suggest favorable biocompatibility applications. This work presents fundamental principles techniques integrating MOFs flexible electronics brain-computer interfaces may provide more customized platforms applications neuroscience, disease tracing, smart diagnostics.

Language: Английский

---

Wireless, fully implantable cardiac stimulation and recording with on-device computation for closed-loop pacing and defibrillation

Science Advances, Journal Year: 2022, Volume and Issue: 8(43)

Published: Oct. 26, 2022

Monitoring and control of cardiac function are critical for investigation cardiovascular pathophysiology developing life-saving therapies. However, chronic stimulation the heart in freely moving small animal subjects, which offer a variety genotypes phenotypes, is currently difficult. Specifically, real-time with high spatial temporal resolution not possible. Here, we introduce wireless battery-free device on-board computation multisite enabling optogenetic modulation entire rodent heart. Seamless integration biointerface enabled by machine learning-guided design ultrathin arrays. Long-term pacing, recording, demonstrated animals. This class enables new failure models offers platform to test therapeutic paradigms over time scales providing means continuously lifetime subject.

Language: Английский

---

A silk-based self-adaptive flexible opto-electro neural probe

Microsystems & Nanoengineering, Journal Year: 2022, Volume and Issue: 8(1)

Published: Nov. 8, 2022

The combination of optogenetics and electrophysiological recording enables high-precision bidirectional interactions between neural interfaces circuits, which provides a promising approach for the study progressive neurophysiological phenomena. Opto-electrophysiological probes with sufficient flexibility biocompatibility are desirable to match low mechanical stiffness brain tissue chronic reliable performance. However, lack rigidity poses challenges accurate implantation flexible less invasiveness. Herein, we report hybrid probe (Silk-Optrode) consisting silk protein optical fiber multiple microelectrode arrays. Silk-Optrode can be accurately inserted into perform synchronized optogenetic stimulation multichannel in freely behaving animals. Silk plays an important role due its high transparency, excellent biocompatibility, controllability. Through hydration fiber, itself actively adapt environment after reduce own implant fidelity while maintaining compliance surrounding tissue. 128 channels detect high-yield well-isolated single units performing intracranial light losses, surpassing previous work similar type. Two months post-surgery results suggested that as-reported exhibit better implant-neural immunoreactive glial responses lesions. A fiber-based natural micro/nano electrode array is reported. multifunctional soft modify Young's modulus through achieve brain. loss single-unit abilities allow simultaneous readout, expands applications operation parsing circuits behavioral

Language: Английский

---

Ionic communication for implantable bioelectronics

Science Advances, Journal Year: 2022, Volume and Issue: 8(14)

Published: April 6, 2022

Implanted bioelectronic devices require data transmission through tissue, but ionic conductivity and inhomogeneity of this medium complicate conventional communication approaches. Here, we introduce (IC) that uses ions to effectively propagate megahertz-range signals. We demonstrate IC operates by generating sensing electrical potential energy within polarizable media. was tuned transmit across a range biologically relevant tissue depths. The radius propagation controlled enable multiline parallel communication, it did not interfere with concurrent use other bioelectronics. created fully implantable IC-based neural interface device acquired noninvasively transmitted neurophysiologic from freely moving rodents over period weeks stability sufficient for isolation action potentials individual neurons. is based establishes long-term, high-fidelity interactions intact tissue.

Language: Английский

---