Altered structural brain asymmetry in autism spectrum disorder in a study of 54 datasets

Nature Communications, Journal Year: 2019, Volume and Issue: 10(1)

Published: Oct. 31, 2019

Abstract Altered structural brain asymmetry in autism spectrum disorder (ASD) has been reported. However, findings have inconsistent, likely due to limited sample sizes. Here we investigated 1,774 individuals with ASD and 1,809 controls, from 54 independent data sets of the ENIGMA consortium. was significantly associated alterations cortical thickness mostly medial frontal, orbitofrontal, cingulate inferior temporal areas, also orbitofrontal surface area. These differences generally involved reduced compared controls. Furthermore, putamen volume increased ASD. The largest case-control effect size Cohen’s d = −0.13, for superior frontal thickness. Most effects did not depend on age, sex, IQ, severity or medication use. lateralized neurodevelopment may therefore be a feature ASD, affecting widespread regions diverse functions. Large-scale analysis necessary quantify subtle

Language: Английский

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Toward Neurosubtypes in Autism

Biological Psychiatry, Journal Year: 2020, Volume and Issue: 88(1), P. 111 - 128

Published: April 22, 2020

Language: Английский

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Sex and gender in neurodevelopmental conditions

Nature Reviews Neurology, Journal Year: 2023, Volume and Issue: 19(3), P. 136 - 159

Published: Feb. 6, 2023

Language: Английский

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The neuropathology of autism: A systematic review of post-mortem studies of autism and related disorders

Neuroscience & Biobehavioral Reviews, Journal Year: 2021, Volume and Issue: 129, P. 35 - 62

Published: July 14, 2021

Language: Английский

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Investigating the impact of motion in the scanner on brain age predictions

Imaging Neuroscience, Journal Year: 2024, Volume and Issue: 2, P. 1 - 21

Published: Jan. 11, 2024

Abstract Brain Age Gap (BAG) is defined as the difference between brain’s predicted age and chronological of an individual. Magnetic resonance imaging (MRI)-based BAG can quantify acceleration brain aging, used to infer health aging disease interact. Motion in scanner a common occurrence that affect acquired MRI data act major confound derived models. As such, age-related changes head motion may impact observed differences. However, relationship estimated by structural has not been systematically examined. The aim this study assess on voxel-based morphometry (VBM) based BAG. Data were obtained from two sources: i) T1-weighted (T1w) MRIs Cambridge Centre for Ageing Neuroscience (CamCAN) train prediction model, ii) T1w Movement-related artifacts (MR-ART) dataset MR-ART includes one motion-free motion-affected (one low high) 3D MRIs. We also visually rated levels 0 5, with meaning no 5 high levels. All images pre-processed through standard VBM pipeline. GM density across cortical subcortical regions then model motion. Principal component analysis was perform dimension reduction extract VBM-based features. regressing out portion delta explained age. Linear mixed-effects models investigate session well severity, including participant IDs random effects. repeated same using thickness FreeSurfer 7.4.1 compare results volumetric versus surface-based measures morphometry. In contrast induced motion, significantly higher sessions 2.35 years (t = 5.17, p < 0.0001), marginal effect 0.95 2.11, 0.035) 3.46 11.45, 0.0001) 2.28 7.54, thickness. addition, associated severity evaluated visual rating 0.45 per level 4.59, 0.83 12.89, analysis. estimates, needs be accounted confound, particularly when studying populations are known have scanner. These significant implications studies neurodegeneration. Based these findings, we recommend assessment inclusion ratings such studies. cases proves prohibitive, normalized Euler number manuscript covariate

Language: Английский

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Intrinsic excitation-inhibition imbalance affects medial prefrontal cortex differently in autistic men versus women

eLife, Journal Year: 2020, Volume and Issue: 9

Published: Aug. 4, 2020

Excitation-inhibition (E:I) imbalance is theorized as an important pathophysiological mechanism in autism. Autism affects males more frequently than females and sex-related mechanisms (e.g., X-linked genes, androgen hormones) can influence E:I balance. This suggests that may affect autism differently versus females. With a combination of in-silico modeling in-vivo chemogenetic manipulations mice, we first show time-series metric estimated from fMRI BOLD signal, the Hurst exponent (H), be index for underlying change synaptic ratio. In find H reduced, indicating increased excitation, medial prefrontal cortex (MPFC) autistic but not Increasingly intact MPFC also associated with heightened ability to behaviorally camouflage social-communicative difficulties, only work ratio differently.

Language: Английский

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A normative modelling approach reveals age-atypical cortical thickness in a subgroup of males with autism spectrum disorder

Communications Biology, Journal Year: 2020, Volume and Issue: 3(1)

Published: Sept. 4, 2020

Understanding heterogeneity is an important goal on the path to precision medicine for autism spectrum disorders (ASD). We examined how cortical thickness (CT) in ASD can be parameterized as individualized metric of atypicality relative typically-developing (TD) age-related norms. Across a large sample (n = 870 per group) and wide age range (5-40 years), we applied normative modelling resulting whole-brain maps CT isolating small subgroup with highly age-atypical CT. Age-normed scores also highlights on-average differentiation, associations behavioural symptomatology that separate from insights gleaned traditional case-control approaches. This work showcases approach understanding could potentially further prioritize subset individuals pathophysiology represented atypicality. Only are actually atypical age-norms. driving differences.

Language: Английский

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Opportunities for increased reproducibility and replicability of developmental neuroimaging

Developmental Cognitive Neuroscience, Journal Year: 2020, Volume and Issue: 47, P. 100902 - 100902

Published: Dec. 18, 2020

Many workflows and tools that aim to increase the reproducibility replicability of research findings have been suggested. In this review, we discuss opportunities these efforts offer for field developmental cognitive neuroscience, in particular neuroimaging. We focus on issues broadly related statistical power flexibility transparency data analyses. Critical considerations relating include challenges recruitment testing young populations, how value studies with small samples, working large-scale datasets. Developmental involve such as choices about age groupings, lifespan modelling, analyses longitudinal changes, can be processed analyzed a multitude ways. Flexibility acquisition, description may thereby greatly impact results. methods improving neuroimaging, preregistration improve methodological rigor. While outlining arise before, during, after collection, solutions resources are highlighted aiding overcome some these. Since number useful techniques is ever-growing, highlight fact many practices implemented stepwise.

Language: Английский

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Brain-based sex differences in autism spectrum disorder across the lifespan: A systematic review of structural MRI, fMRI, and DTI findings

NeuroImage Clinical, Journal Year: 2021, Volume and Issue: 31, P. 102719 - 102719

Published: Jan. 1, 2021

Females with autism spectrum disorder (ASD) have been long overlooked in neuroscience research, but emerging evidence suggests they show distinct phenotypic trajectories and age-related brain differences. Sex-related biological factors (e.g., hormones, genes) may play a role ASD etiology shown to influence neurodevelopmental trajectories. Thus, lifespan approach is warranted understand brain-based sex differences ASD. This systematic review on MRI-based was conducted elucidate variations across the inform biomarker discovery of females We identified articles through two database searches. Fifty studies met criteria underwent integrative review. found that regions expressing replicable sex-by-diagnosis overlapped showing neurotypical cohorts. Furthermore, investigating broad age-span suggest patterns Qualitative comparison youth adult also supported this hypothesis. However, many collapsed age, which mask accumulating supports female protective effect ASD, although only one study examined circuits implicated "protection." When synthesized broader literature, come from various sources, including genetic endocrine processes involved "masculinization" "feminization" early development, puberty, other windows hormonal transition. sex-related biology interact peripheral processes, particular stress axis arousal system, produce males Future research neuroimaging-based would benefit well-controlled multivariate studies. Possible relationships between behavior, development remain largely unexamined.

Language: Английский

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Early or Late Gestational Exposure to Maternal Immune Activation Alters Neurodevelopmental Trajectories in Mice: An Integrated Neuroimaging, Behavioral, and Transcriptional Study

Biological Psychiatry, Journal Year: 2021, Volume and Issue: 90(5), P. 328 - 341

Published: March 23, 2021

Language: Английский

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