Journal of Neurochemistry,
Journal Year:
2023,
Volume and Issue:
165(5), P. 625 - 642
Published: March 31, 2023
Brain
iron
homeostasis
is
crucial
for
neurological
health,
with
pathological
fluctuations
in
brain
levels
associated
a
variety
of
disorders.
Low
are
connected
to
cognitive
impairment
and
restless
legs
syndrome,
while
high
Alzheimer's
disease,
Parkinson's
other
neurodegenerative
diseases.
Given
the
detrimental
effects
unrestricted
can
have,
regulated
entry
into
via
transferrin
H-ferritin
critical.
Endothelial
cells
blood-brain
barrier
site
transport
regulation.
The
movement
through
endothelial
be
divided
three
distinct
processes:
uptake,
transcytosis,
release.
Each
process
possesses
external
internal
influences
on
regulation
at
each
stage.
This
review
discusses
mechanisms
release
barrier,
as
well
elements
that
contribute
Additionally,
we
explore
dysregulation
syndrome.
BMC Infectious Diseases,
Journal Year:
2025,
Volume and Issue:
25(1)
Published: Jan. 14, 2025
C-reactive
protein
(CRP)
is
one
of
the
most
commonly
monitored
inflammatory
markers
in
patients
with
COVID-19
to
gain
insight
into
inflammation
level
body
and
adopt
effective
disease
management
therapeutic
strategies.
now
less
prevalent,
study
CRP
as
a
biomarker
still
needs
deeper
understanding,
particularly
understanding
its
role
among
comorbidities,
which
are
known
influence
responses
increase
risk
severe
outcomes
during
acute
chronic
infectious
diseases.
The
objective
this
was
evaluate
association
major
comorbidities
such
ischemic
heart
diseases,
diabetes,
kidney
disease,
hypertension,
lung
infections
e.g.
tuberculosis
serum
levels
hospitalized
patients.
This
involves
retrospective
observational
framework
monitor
after
getting
ethical
approval
patient
consent.
information
on
underlying
health
conditions
or
age
collected
from
data
files.
requirement
ventilation,
ICU
admission,
mortality
&
survival,
were
based
their
daily
updates
file.
Furthermore,
evaluated
severity
mortality.
In
618
out
750
patients,
62.6%
male
37.4%
female,
significantly
influenced
by
comorbidities.
No
case
hospitalization
observed
children
(≤
14
years)
period,
while
38.3%
belonged
old
group
(≥
65
years).
Comorbidity
status
varied,
36.1%
without
having
any
27.8%
one,
23.6%
two,
12.5%
three
more
Descriptive
statistics
revealed
that
population
averaged
88.92
mg/L
(SD
=
63.95),
ranging
<
1
900
mg/L,
significant
variations
across
different
groups.
levels,
analyzed
Kruskal-Wallis
test,
showed
groups
(χ²
66.741,
df
3,
p
0.001).
Moreover,
pairwise
comparisons
considerable
differences
between
young
middle-aged
(Z
-2.724,
0.01)
-3.970,
prevalent
hypertension
(42.1%),
diabetes
(33.8%),
(16.5%),
asthma
(11.2%),
(7.9%)
Tuberculosis
(1.9%).
fluctuate
also
differ
have
higher
than
non-diabetics
(mean
CRP:
126.96
vs.
Z
-5.724,
0.001),
those
encountered
elevated
355.37
276.19
-5.447,
Similar
tendencies
detected
385.43
-4.704,
412.37
-4.206,
0.001)
well
458.08
-2.914,
0.01).
days
3
decline
(88.92
67.89
mg/L),
representative
response
treatment
reduce
body.
high
associated
non-invasive
ventilation
110.80
76.82
0.05),
mechanical
134.46
77.25
0.05)
admission
72.79
0.05).
Cox
regression
analysis
there
expected
length
hospitalization,
each
1-unit
0.6%
extended
stay
(hazard
ratio
1.006,
95%
CI:
1.004–1.008,
logistic
performed
first
day
2.7%
odds
unit
(odds
1.027,
1.022–1.033,
suggest
potential
predictor.
Elevated
like
strongly
increased
severity,
including
requirements
Patients
these
correlated
worse
outcomes,
admissions
prolonged
hospital
stays,
emphasizing
importance
predictor
for
complications
diseases
along
Frontiers in Aging Neuroscience,
Journal Year:
2023,
Volume and Issue:
15
Published: May 30, 2023
A
progressive
degradation
of
the
brain’s
structure
and
function,
which
results
in
a
reduction
cognitive
motor
skills,
characterizes
neurodegenerative
diseases
(NDs)
such
as
Alzheimer’s
disease
(AD),
Parkinson’s
(PD),
Amyotrophic
lateral
sclerosis
(ALS),
Huntington’s
(HD).
The
morbidity
linked
to
NDs
is
growing,
poses
severe
threat
human
being’s
mental
physical
ability
live
well.
gut-brain
axis
(GBA)
now
known
have
crucial
role
emergence
NDs.
gut
microbiota
conduit
for
GBA,
two-way
communication
system
between
brain.
myriad
microorganisms
that
make
up
can
affect
brain
physiology
by
transmitting
numerous
microbial
chemicals
from
via
GBA
or
neurological
system.
synthesis
neurotransmitters,
immunological
response,
metabolism
lipids
glucose
all
been
demonstrated
be
impacted
alterations
microbiota,
an
imbalance
helpful
harmful
bacteria.
In
order
develop
innovative
interventions
clinical
therapies
NDs,
it
comprehend
participation
these
conditions.
addition
using
antibiotics
other
drugs
target
particular
bacterial
species
may
factor
this
also
includes
probiotics
fecal
transplantation
maintain
healthy
microbiota.
conclusion,
examination
aid
understanding
etiology
development
benefit
improvement
treatments
disorders
ND
interventions.
This
review
indicates
existing
knowledge
about
involvement
present
potential
treatment
options.
Journal of Neurochemistry,
Journal Year:
2023,
Volume and Issue:
165(5), P. 625 - 642
Published: March 31, 2023
Brain
iron
homeostasis
is
crucial
for
neurological
health,
with
pathological
fluctuations
in
brain
levels
associated
a
variety
of
disorders.
Low
are
connected
to
cognitive
impairment
and
restless
legs
syndrome,
while
high
Alzheimer's
disease,
Parkinson's
other
neurodegenerative
diseases.
Given
the
detrimental
effects
unrestricted
can
have,
regulated
entry
into
via
transferrin
H-ferritin
critical.
Endothelial
cells
blood-brain
barrier
site
transport
regulation.
The
movement
through
endothelial
be
divided
three
distinct
processes:
uptake,
transcytosis,
release.
Each
process
possesses
external
internal
influences
on
regulation
at
each
stage.
This
review
discusses
mechanisms
release
barrier,
as
well
elements
that
contribute
Additionally,
we
explore
dysregulation
syndrome.
