Detection, processing and reinforcement of social cues: regulation by the oxytocin system

Nature reviews. Neuroscience, Journal Year: 2023, Volume and Issue: 24(12), P. 761 - 777

Published: Oct. 27, 2023

Language: Английский

---

The psychophysiology of music-based interventions and the experience of pain

Frontiers in Psychology, Journal Year: 2024, Volume and Issue: 15

Published: May 10, 2024

In modern times there is increasing acceptance that music-based interventions are useful aids in the clinical treatment of a range neurological and psychiatric conditions, including helping to reduce perception pain. Indeed, belief music, whether listening or performing, can alter human pain experiences has long history, dating back ancient Greeks, its potential healing properties have been appreciated by indigenous cultures around world. The subjective experience acute chronic complex, influenced many intersecting physiological psychological factors, it therefore be expected impact music therapy on may vary from one situation another, person another. Where persists becomes chronic, aberrant central processing key feature associated with ongoing experience. Nonetheless, beneficial effects exposure relief reported across wide shown effective neonates, children adults. this comprehensive review we examine various neurochemical, factors underpin experience, potentially operate at levels – periphery, spinal cord, brainstem, limbic system multiple areas cerebral cortex. We discuss extent which these individually combination, influence how affects both quality intensity pain, noting remains controversy about respective roles diverse peripheral processes play Better understanding mechanisms underlie music’s together insights into should aid developing more synergistic approaches when combined treatments. ubiquitous nature also facilitates application therapeutic environment daily life, for individual social benefit.

Language: Английский

---

A Pilot Randomized Clinical Trial of Intranasal Oxytocin to Promote Weight Loss in Individuals With Hypothalamic Obesity

Journal of the Endocrine Society, Journal Year: 2023, Volume and Issue: 7(5)

Published: March 6, 2023

Abstract Context Hypothalamic obesity is a rare, treatment-resistant form of obesity. In preliminary studies, the hypothalamic hormone oxytocin (OXT) has shown promise as potential weight loss therapy. Objective To determine whether 8 weeks intranasal OXT (vs placebo) promotes in children, adolescents, and young adults with Methods This randomized, double-blind, placebo-controlled, crossover pilot trial (NCT02849743), conducted at an outpatient academic medical center, included patients aged 10 to 35 years from hypothalamic/pituitary tumors. Participants received (Syntocinon, 40 USP units/mL, 4 IU/spray) vs excipient-matched placebo, 16 24 IU 3 times daily mealtimes. Weight attributable placebo safety (adverse events) were assessed. Results Of 13 individuals randomized (54% female, 31% pre-pubertal, median age 15.3 years, IQR 13.3-20.6), completed entire study. We observed nonsignificant within-subject change −0.6 kg (95% CI: −2.7, 1.5) placebo. A subset (2/18 screened, 5/13 randomized) had prolonged QTc interval on electrocardiography prior screening and/or both treatment conditions. Overall, was well-tolerated, adverse events (epistaxis nasal irritation, headache, nausea/vomiting, changes heart rate, blood pressure, interval) similar between exploratory analyses, benefits for anxiety impulsivity observed. Conclusion this study obesity, we did not detect significant impact body weight. so future larger studies could examine different dosing, combination therapies, psychosocial benefits.

Language: Английский

---

Intertwined associations between oxytocin, immune system and major depressive disorder

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 163, P. 114852 - 114852

Published: May 8, 2023

Major depressive disorder (MDD) is a prominent psychiatric with high prevalence rate. The recent COVID-19 pandemic has exacerbated the already of MDD. Unfortunately, significant proportion patients are unresponsive to conventional treatments, necessitating exploration novel therapeutic strategies. Oxytocin, an endogenous neuropeptide, emerged as promising candidate anxiolytic and antidepressant properties. Oxytocin been shown alleviate emotional disorders by modulating hypothalamic-pituitary-adrenal (HPA) axis central immune system. dysfunction system strongly linked onset progression depression. believed be key target oxytocin in ameliorating disorders. In this review, we examine evidence regarding interactions between oxytocin, system, disorder. Moreover, summarize speculate on potential roles intertwined association treating

Language: Английский

---

Exploring the influence of stress on aggressive behavior and sexual function: Role of neuromodulator pathways and epigenetics

Heliyon, Journal Year: 2024, Volume and Issue: 10(5), P. e27501 - e27501

Published: March 1, 2024

Stress is a complex and multifaceted phenomenon that can significantly influence both aggressive behavior sexual function. This review explores the intricate relationship between stress, neuromodulator pathways, epigenetics, shedding light on various mechanisms underlie these connections. While role of stress in aggression well-documented, through which it exerts its effects are multifarious not yet fully understood. The begins by delving into potential Hypothalamic-Pituitary-Adrenal (HPA) axis, glucocorticoids, neuromodulators involved response. interplay systems, encompasses regulation hormones, central to understanding how may contribute Several pathways implicated regulation. We explore roles norepinephrine, serotonin, oxytocin, androgens mediating It important distinguish general behavior, motivation, distinct category "sexual aggression" as separate constructs, each necessitating specific examination. Additionally, epigenetic emerge crucial factors link changes gene expression patterns and, subsequently, behavior. then discuss modifications occur response exposure, altering genes associated with aggression, numerous studies support association stress-induced more research necessary establish definitive links. Throughout this exploration, becomes increasingly clear epigenetics multifaceted. emphasizes need for further research, particularly context human studies, provide clinical significance validate existing findings from animal models. By better influences function modifications, aims development innovative protocols precision medicine effective strategies managing consequences also pave way risk underlying associate finds application only neuroscience, but law, ethics, humanities general.

Language: Английский

---

The ecology of ageing in wild societies: linking age structure and social behaviour

Philosophical Transactions of the Royal Society B Biological Sciences, Journal Year: 2024, Volume and Issue: 379(1916)

Published: Oct. 28, 2024

The age of individuals has consequences not only for their fitness and behaviour but also the functioning groups they form. Because social often changes with age, population structure is expected to shape organization, environments experience operation processes within populations. Although research explored in individual particularly controlled settings, there limited understanding how governs sociality wild Here, we synthesize previous into age-related effects on natural populations, discuss links between structure, ecology, specifically focusing might influence functioning. We highlight potential using empirical data from populations combination network approaches uncover pathways linking ageing, societal broader implications these insights impacts anthropogenic animal demography building a deeper ageing general. This article part discussion meeting issue ‘Understanding society populations’.

Language: Английский

---

Potential Mechanisms of Action and Outcomes of Equine-Assisted Services for Veterans with a History of Trauma: A Narrative Review of the Literature

International Journal of Environmental Research and Public Health, Journal Year: 2023, Volume and Issue: 20(14), P. 6377 - 6377

Published: July 16, 2023

Equine-assisted services (EASs) are being increasingly used as complementary interventions for military veterans who have experienced trauma. However, there is limited evidence of benefit this population and almost no literature describing the desired potential outcomes possible mechanisms action. The aim article to address these gaps by reviewing extant animal-assisted in general, equine-assisted particular, with goal providing guidance future investigations field. Currently, field early stage scientific development, but published results promising. Interventions that enhance treatment compliance and/or could population. Preliminary results, reviewed herein, indicate EAS might veteran enhancing engagement therapeutic alliance, well contributing symptom reduction resulting various transdiagnostic benefits. It recommended studies include exploration beneficial discussed investigate suggested

Language: Английский

---

Oxytocin transported from the blood across the blood-brain barrier by receptor for advanced glycation end-products (RAGE) affects brain function related to social behavior

Peptides, Journal Year: 2024, Volume and Issue: 178, P. 171230 - 171230

Published: April 26, 2024

Language: Английский

---

Mother–Young Bonding: Neurobiological Aspects and Maternal Biochemical Signaling in Altricial Domesticated Mammals

Animals, Journal Year: 2023, Volume and Issue: 13(3), P. 532 - 532

Published: Feb. 2, 2023

Mother–young bonding is a type of early learning where the female and their newborn recognize each other through series neurobiological mechanisms neurotransmitters that establish behavioral preference for filial individuals. This process essential to promote welfare by providing maternal care, particularly in altricial species, animals require extended parental care due limited neurodevelopment at birth. Olfactory, auditory, tactile, visual stimuli trigger neural integration multimodal sensory conditioned affective associations mammals. review aims discuss aspects processes mammals, with focus on brain structures involved how these influence signaling during first days life newborns.

Language: Английский

---

Microbes, oxytocin and stress: Converging players regulating eating behavior

Journal of Neuroendocrinology, Journal Year: 2023, Volume and Issue: 35(9)

Published: Feb. 15, 2023

Oxytocin is a peptide-hormone extensively studied for its multifaceted biological functions and has recently gained attention role in eating behavior, through action as an anorexigenic neuropeptide. Moreover, the gut microbiota involved oxytocinergic signaling brain-gut axis, specifically regulation of social behavior. The also implicated appetite postulated to play central hedonic eating. In this review, we provide overview on oxytocin individual links with microbiome, homeostatic non-homeostatic behavior well stress.

Language: Английский

---