The existential realities of dancing DOI Creative Commons
Maxine Sheets‐Johnstone

Frontiers in Cognition, Journal Year: 2024, Volume and Issue: 3

Published: June 13, 2024

Can we again learn about ourselves and our surrounding world through dance as age, thereby promoting own health? This article documents facts of life showing that “older adults” do not have to be cognitive their movement, affective dispositions, or world; they been experientially all by way tactility, kinesthesia, affectivity from the beginning. Present-day neuroscience, concentrating theorizing it does on brain's neuroplasticity, is however deficient in recognizing these experiential realities. Research studies brain behavior, contrast, demonstrate coordination dynamics are defining feature both neurological kinesthetic dynamics. These central corporeal concepts, recognition if–then relationships, thinking movement. In effect, part a whole-body nervous system. The study proceeds show qualitative movement subtend basic only everyday but also dancing—to experiencing kinesthetically being mindful body. When Merce Cunningham writes gives you “single fleeting moment when feel alive” for “unsteady souls” English writer D. H. Lawrence “[w]e ought with rapture alive, flesh, living incarnate cosmos,” words incentives those who aging awaken tactilely, kinesthetically, affectively existential realities dance.

Language: Английский

Unraveling the Enigmatic Potential of the Brain: Exploring Neuroplasticity's Role in Brain Health and Therapy DOI Creative Commons

Pranavi Bandaru,

Mithusan Sivarajah

Undergraduate Research in Natural and Clinical Science and Technology (URNCST) Journal, Journal Year: 2025, Volume and Issue: 9(1), P. 1 - 6

Published: Jan. 16, 2025

Introduction: Neuroplasticity, a cornerstone of contemporary neuroscience, refers to the brain's intrinsic ability reorganize its structure and function in response experience, learning, environmental stimuli. This dynamic adaptability highlights capacity for growth repair, providing critical insights into mechanisms underpinning neural development, rehabilitation, lifelong cognitive flexibility. History: Spearheaded by notable scientists, concept neuroplasticity rose prominence 20th century, forging novel understanding neuroscience. In 1949, Donald Hebb proposed that neurons activated together during memory recall are bound connect, establishing Hebbian theory laying foundation modern studies. Furthermore, neuroscientist Michael Merzenich advanced neuroplasticity's perpetual nature relation functioning. Fundamental Concepts: Synaptic plasticity cortical remapping neuroplasticity. is synapses strengthen or weaken over time activity, playing crucial role learning processes. Studies suggest synaptic initiating mechanism remapping, which reorganization neuronal connections cerebral cortex. underlies adaptive behaviours observed sensory experiences, specifically optimizing processing better adjust changes Current Research: research investigates cognition, psychiatric neurodegenerative disorders particularly using neuroimaging techniques visualize complex networks. Additionally, avenues investigating invasive methods such as deep brain stimulation (DBS), training hypoxia induction, along with non-invasive transcranial magnetic (TMS), low-intensity focused ultrasound (LIFUS) electrical (TES), offer promising therapeutic interventions. Research also focuses on encouraging recreational activities identifying pharmacological remedies, intending develop more effective therapies fewer side effects. Future Implications: Neuroplasticity has far-reaching implications education, clinical therapy, enhancement. However, challenges persist, including deciphering individual variability neuroplastic responses interventions maximize positive outcomes. Addressing these promises unlock new frontiers harnessing improved function, ultimately paving way tailored profiles.

Language: Английский

Citations

1
Lasting dynamic effects of the psychedelic 2,5-dimethoxy-4-iodoamphetamine ((±)-DOI) on cognitive flexibility DOI Creative Commons
Merima Šabanović, Alberto Lazari, Marta Blanco-Pozo

et al.

Molecular Psychiatry, Journal Year: 2024, Volume and Issue: 29(6), P. 1810 - 1823

Published: Feb. 7, 2024

Psychedelic drugs can aid fast and lasting remission from various neuropsychiatric disorders, though the underlying mechanisms remain unclear. Preclinical studies suggest serotonergic psychedelics enhance neuronal plasticity, but whether neuroplastic changes also be seen at cognitive behavioural levels is unexplored. Here we show that a single dose of psychedelic 2,5-dimethoxy-4-iodoamphetamine ((±)-DOI) affects structural brain plasticity flexibility in young adult mice beyond acute drug experience. Using ex vivo magnetic resonance imaging, increased volumes several sensory association areas one day after systemic administration 2 mgkg

Language: Английский

Citations

6
The digital twin in neuroscience: from theory to tailored therapy DOI Creative Commons
Lucius S. Fekonja,

Robert Schenk,

E Schröder

et al.

Frontiers in Neuroscience, Journal Year: 2024, Volume and Issue: 18

Published: Sept. 17, 2024

Digital twins enable simulation, comprehensive analysis and predictions, as virtual representations of physical systems. They are also finding increasing interest application in the healthcare sector, with a particular focus on digital brain. We discuss how neuroscience modeling brain functions pathology they offer an in-silico approach to studying illustrating complex relationships between network dynamics related functions. To showcase capabilities twinning we demonstrate impact tumors brain’s structures functioning can be modeled relation philosophical concept plasticity. Against this technically derived backdrop, which assumes that nonlinear behavior toward improvement repair predicted based MRI data, further explore insights Catherine Malabou. Malabou emphasizes dual capacity for adaptive destructive will far Malabou’s ideas provide more holistic theoretical framework understanding model response injury pathology, embracing both plasticity provides address such yet incomputable aspects sometimes seemingly unfavorable neuroplasticity helping bridge gap research clinical practice.

Language: Английский

Citations

6
Fluoxetine and Ketamine Enhance Extinction Memory and Brain Plasticity by Triggering the p75 Neurotrophin Receptor Proteolytic Pathway DOI Creative Commons
Cassiano R.A.F. Diniz, Ana Paula Crestani,

Plinio Cabrera Casarotto

et al.

Biological Psychiatry, Journal Year: 2024, Volume and Issue: unknown

Published: June 1, 2024

BackgroundDiverse antidepressants were recently described to bind TrkB (tyrosine kinase B) and drive a positive allosteric modulation of endogenous BDNF (brain-derived neurotrophic factor). Although neurotrophins such as can p75NTR (p75 neurotrophin receptor), their precursors are the high-affinity ligands. While part an unrelated receptor family capable inducing completely opposite physiological changes, feature crosslike conformation dimer carry cholesterol-recognition amino acid consensus in transmembrane domain. As qualities found be crucial for behavioral neuroplasticity effects, we hypothesized that effects might also depend on p75NTR.MethodsEnzyme-linked immunosorbent assay–based binding nuclear magnetic resonance spectroscopy performed assess whether would p75NTR. HEK293T cells variety vitro assays used investigate fluoxetine (FLX) or ketamine (KET) trigger any α- γ-secretase–dependent proteolysis lead localization. Ocular dominance shift was with male female knockout mice study KET FLX brain plasticity, addition pharmacological interventions verify how signaling is important enhancing extinction memory wild-type rats.ResultsAntidepressants triggered proteolytic pathway induced p75NTR-dependent behavioral/neuroplasticity changes.ConclusionsWe hypothesize co-opt both BDNF/TrkB proBDNF/p75NTR systems induce more efficient activity-dependent synaptic competition, thereby boosting brain's ability remodeling.

Language: Английский

Citations

4
The dynamic relationship of brain‐derived neurotrophic factor and oxytocin: Introducing the concept of neurosocial plasticity DOI Creative Commons
Jamshid Faraji, Gerlinde A. S. Metz

Neuroprotection/Neuroprotection (Chichester, England. Print), Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 10, 2025

Abstract The human brain functions as a highly integrated system. Interconnected cellular and molecular networks within this system process sensory information, cognitive functions, motor responses. also exhibits remarkable potential for plasticity‐driven adaptive learning memory. Importantly, neuroplasticity serves key mechanism of neuroprotection while enabling the to compensate injury through structural remodeling. Understanding dynamic requires examining how its components interact produce physiological responses complex behaviors, such social interactions. Key molecules, brain‐derived neurotrophic factor (BDNF) oxytocin (OT), play pivotal roles in maintaining brain's complexity integrative functioning. In review, we introduce concept “neurosocial plasticity”, which refers ability adapt both neural circuitry behavior interaction between BDNF OT. This highlights BDNF–OT interactions may support plasticity capacity We then explore their co‐localization, co‐expression, co‐regulation regulate plasticity, ultimately shaping adaptability development behaviors across various contexts.

Language: Английский

Citations

0
COVID-19 Pandemic Impacts on STRESS, PTSD, and Prefrontal Cortical Thickness in Pre-Pandemic Trauma Survivors DOI Open Access

Sharad Chandra,

Atheer Amer, Chia-Hao Shih

et al.

Journal of Personalized Medicine, Journal Year: 2025, Volume and Issue: 15(4), P. 127 - 127

Published: March 26, 2025

Background/Objectives: The COVID-19 pandemic increased psychiatric symptoms in patients with pre-pandemic mental health conditions. However, the effects of on brain, stress, and illness remain largely conjectural. Our objective was to examine how affected prefrontal cortical thicknesses (CTs), PTSD people trauma histories. Methods: Fifty-one survivors from a study who had completed Checklist-5 (PCL) assess sMRI scan measure CTs were re-recruited after pandemic. They subsequently COVID Stress Scale (CSS) Clinician Administered Scale-5 (CAPS) diagnose PTSD, second scan. infection self-reported. Associations between stress symptom assessments post-pandemic CTs, differences vs. non-PTSD groups, changes pre- examined. Results: Pre-pandemic PCL scores positively associated CSS which, turn, higher group. Thicker IFG-opercularis infection. Post-pandemic rMFG IFG-orbitalis CAPS scores. rACC negatively Pre- frontal pole thickened group but thinned group, whereas Conclusions: These findings provide novel evidence that diverse involving cortex structure, subjects history suggest treatments are needed counter these effects.

Language: Английский

Citations

0
Linking Brain Circuitry and Neural Plasticity in Antidepressant Response: The mPFC-Reuniens-Hippocampus Pathway. DOI
Stefan Vestring, Maxime Veleanu, Jochen Weber

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: April 3, 2025

Abstract The pathophysiology of depression involves multiple biological processes, including circuit dysfunction and impaired neuroplasticity, yet an integrative view that links these processes remains elusive. Here, using a combination manipulation, electrophysiology, behavior, fiber photometry, we identify convergent for antidepressant response plasticity modulation. We demonstrate chemogenetic activation the infralimbic cortex (IL) is sufficient to exert rapid effects across behavioral domains in mouse model stress-induced exerts top-down control over hippocampal processing. show IL stimulation enhances structural plasticity, restores long-term potentiation improves state-dependent network dynamics hippocampus (HIP). identified nucleus reuniens (RE) as necessary mediator effects. Notably, RE inhibition blocks not only stimulation-induced but also therapeutic neuroplastic ketamine. Our findings functional → ventral HIP plays central role response, linking activity, depressive-like behaviors.

Language: Английский

Citations

0
Indigenous epistemologies, Two-Eyed Seeing, and the philosophy, practice, and applications of brain sciences DOI

T. Ryan Gregory,

Rudi Louis Taylor-Bragge, Andre D. McLachlan

et al.

Developments in neuroethics and bioethics, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

0
The neuroplastic brain: current breakthroughs and emerging frontiers DOI Creative Commons
Parisa Gazerani

Brain Research, Journal Year: 2025, Volume and Issue: unknown, P. 149643 - 149643

Published: April 1, 2025

Language: Английский

Citations

0
Single electrically induced epileptic afterdischarge triggers synaptic weakening, AMPA receptor endocytosis and shrinkage of dendritic spines in the hippocampus DOI Creative Commons
Ana Paula Crestani, Leonardo Rakauskas Zacharias, Danilo Benette Marques

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: April 20, 2025

Abstract Afterdischarge (AD) is an experimental model of electrically induced seizures. When in limbic structures, AD known to induce acute behavioral alterations and flattening local field potentials that persist for a few minutes. However, impairments more complex cognitive processes such as learning memory, can last hours after the seizure. Considering mismatch between ephemeral postictal electrophysiological changes long-lasting impairments, synaptic plasticity emerges possible mechanism integrates these findings. Therefore, we used multilevel approach evaluate effects single seizure on plasticity. First, showed AD-eliciting stimulation at perforant pathway-dentate gyrus (PP-DG) synapse causes decrease evoked postsynaptic potentials. Then, observed this functional alteration was accompanied by shrinkage mushroom-shaped spines DG. Lastly, reduced levels p(Ser845)-GluA1 GluA1 subunits AMPA receptors (AMPARs) were found hippocampal density. Together, our data suggest induces long-term depression (LTD)-like phenomenon, which characterized weakening, AMPAR endocytosis, dendritic shrinkage. Furthermore, here align with course often reported other studies.

Language: Английский

Citations

0