European Psychiatry,
Journal Year:
2024,
Volume and Issue:
67(1)
Published: Jan. 1, 2024
Abstract
Background
Obesity-related
cardiometabolic
comorbidity
is
common
in
major
depressive
disorder
(MDD).
However,
sex
differences
and
MDD
recurrence
may
modify
the
MDD-obesity-link.
Methods
Sex-specific
associations
of
(single
[MDD
S
]
or
recurrent
episodes
R
])
obesity-related
traits
were
analyzed
4.100
adults
(51.6%
women)
from
a
cross-sectional
population-based
cohort
Germany
(SHIP-Trend-0).
DSM-IV-based
lifetime
diagnoses
status
obtained
through
diagnostic
interviews.
outcomes
included
anthropometrics
(weight,
body
mass
index,
waist-
hip-circumference,
waist-to-hip
ratio,
waist-to-height
ratio),
bioelectrical
impedance
analysis
fat
fat-free
mass,
subcutaneous
(SAT)
visceral
adipose
tissue
(VAT)
abdominal
magnetic
resonance
imaging.
Sex-stratified
linear
regression
models
predicting
adjusted
for
age,
education,
current
symptoms.
Results
790
participants
(19.3%)
fulfilled
criteria
(23.8%
women
vs.
14.5%
men,
p<0.001).
In
women,
was
inversely
associated
with
anthropometric
indicators
general
central
obesity,
while
positively
all
traits,
except
ratio
mass.
versus
higher
levels
obesity
across
SAT
regardless
recurrence.
Additionally,
VAT
men.
remained
significant
sensitivity
analyses
after
exclusion
use
antidepressants.
Conclusions
The
MDD-obesity
association
modified
by
independent
Accounting
identify
individuals
at
increased
risk.
BMC Medicine,
Journal Year:
2023,
Volume and Issue:
21(1)
Published: May 4, 2023
Both
depression
and
breast
cancer
(BC)
contribute
to
a
substantial
global
burden
of
morbidity
mortality
among
women,
previous
studies
have
observed
potential
depression-BC
link.
We
aimed
comprehensively
characterize
the
phenotypic
genetic
relationships
between
BC.We
first
evaluated
association
using
longitudinal
follow-up
data
from
UK
Biobank
(N
=
250,294).
then
investigated
leveraging
summary
statistics
hitherto
largest
genome-wide
study
European
individuals
conducted
for
500,199),
BC
247,173),
its
subtypes
based
on
status
estrogen
receptor
(ER
+
:
N
175,475;
ER
-
127,442).Observational
analysis
suggested
an
increased
hazard
in
patients
(HR
1.10,
95%CIs
0.95-1.26).
A
positive
correlation
overall
was
([Formula:
see
text]
0.08,
P
3.00
×
10-4),
consistent
across
0.06,
6.30
10-3)
7.20
10-3).
Several
specific
genomic
regions
showed
evidence
local
correlation,
including
one
locus
at
9q31.2,
four
loci
at,
or
close,
6p22.1.
Cross-trait
meta-analysis
identified
17
pleiotropic
shared
BC.
TWAS
revealed
five
genes.
Bi-directional
Mendelian
randomization
risk
causally
associated
with
(OR
1.12,
95%Cis
1.04-1.19),
but
not
depression.Our
work
demonstrates
basis,
loci,
putative
causal
relationship
BC,
highlighting
biological
link
underlying
relationship;
these
findings
may
provide
important
implications
future
reducing
risk.
European Neuropsychopharmacology,
Journal Year:
2023,
Volume and Issue:
76, P. 89 - 107
Published: Aug. 16, 2023
Major
depressive
disorder
(MDD)
presents
different
clinical
features
in
women
and
men,
with
being
more
affected
responding
differently
to
antidepressant
treatment.
Specific
molecular
mechanisms
underlying
these
differences
are
not
well
studied
this
narrative
review
aims
at
providing
an
overview
of
the
neurobiological
sex-differences
biological
systems
involved
MDD
pathophysiology
response
treatment,
focusing
on
human
studies.
The
majority
reviewed
studies
were
performed
through
candidate
gene
approaches,
pathophysiology,
including
stress
response,
inflammatory
immune,
monoaminergic,
neurotrophic,
gamma-aminobutyric
acid
glutamatergic,
oxytocin
systems.
influence
endocrine
system
sex-specific
hormone
effects
also
discussed.
Genome,
epigenome
transcriptome-wide
approaches
less
frequently
most
do
focus
alterations,
revealing
a
paucity
omics
directed
unravel
sex-based
MDD.
Few
about
sex-related
treatment
have
been
conducted,
mostly
involving
system,
evidence
monoaminergic
sparse
approaches.
Our
covers
importance
accounting
for
research,
optimizing
patient
stratification
precise
diagnostic
individualized
men.
Advanced Science,
Journal Year:
2024,
Volume and Issue:
11(26)
Published: May 5, 2024
Abstract
Is
childhood
adversity
associated
with
biological
aging,
and
if
so,
does
sex
modify
the
association,
do
lifestyle
mental
health
mediate
association?
A
lifespan
analysis
is
conducted
using
data
on
142
872
participants
from
UK
Biobank
to
address
these
questions.
Childhood
assessed
through
online
questionnaire
(2016),
including
physical
neglect,
abuse,
emotional
sexual
a
cumulative
score.
Biological
aging
indicated
by
telomere
length
(TL)
measured
leukocyte
DNA
qPCR,
shorter
TL
indicates
accelerated
aging;
score
constructed
body
mass
index,
activity,
drinking,
smoking,
diet;
disorder
depression,
anxiety,
insomnia
at
baseline
survey.
The
results
reveal
sex‐specific
association
such
that
in
women
after
adjusting
for
covariates
polygenic
risk
TL,
but
not
men.
Unhealthy
partially
women.
proportions
of
indirect
effects
are
largest
abuse.
These
findings
highlight
importance
behavioral
psychological
interventions
promoting
healthy
among
who
experienced
adversity,
particularly
Genes,
Journal Year:
2024,
Volume and Issue:
15(5), P. 547 - 547
Published: April 25, 2024
Statistical
genetic
models
of
genotype-by-environment
(G×E)
interaction
can
be
divided
into
two
general
classes,
one
on
G×E
in
response
to
dichotomous
environments
(e.g.,
sex,
disease-affection
status,
or
presence/absence
an
exposure)
and
the
other
continuous
physical
activity,
nutritional
measurements,
socioeconomic
measures).
Here
we
develop
a
novel
model
jointly
account
for
environments.
We
terms
joint
genotype-by-sex
(for
environment)
genotype-by-social
determinants
health
(SDoH;
environment).
Using
this
model,
show
how
depression
variable,
as
measured
by
Beck
Depression
Inventory-II
survey
instrument,
is
not
only
underlain
effects
(as
has
been
reported
elsewhere)
but
also
significantly
determined
G×Sex
G×SDoH
effects.
This
numerous
applications
leading
potentially
transformative
research
environmental
underlying
complex
diseases.
