American Journal of Epidemiology,
Journal Year:
2024,
Volume and Issue:
193(11), P. 1541 - 1552
Published: May 17, 2024
Abstract
Childhood
adversity
is
an
important
risk
factor
for
adverse
health
across
the
life
course.
Epigenetic
modifications,
such
as
DNA
methylation
(DNAm),
are
a
hypothesized
mechanism
linking
to
disease
susceptibility.
Yet,
few
studies
have
determined
whether
adversity-related
DNAm
alterations
causally
related
future
outcomes
or
if
their
developmental
timing
plays
role
in
these
relationships.
Here,
we
used
2-sample
mendelian
randomization
obtain
stronger
causal
inferences
about
association
between
adversity-associated
loci
development
(ie,
birth,
childhood,
adolescence,
and
young
adulthood)
24
mental,
physical,
behavioral
outcomes.
We
identified
particularly
strong
associations
attention-deficit/hyperactivity
disorder,
depression,
obsessive-compulsive
suicide
attempts,
asthma,
coronary
artery
disease,
chronic
kidney
disease.
More
of
were
birth
childhood
DNAm,
whereas
adolescent
adulthood
more
closely
linked
mental
health.
also
had
primarily
risk-suppressing
relationships
with
outcomes,
suggesting
that
might
reflect
compensatory
buffering
mechanisms
against
rather
than
acting
solely
indicator
risk.
Together,
our
results
suggest
both
physical
impacts
differences
emerging
earlier
development.
Current Environmental Health Reports,
Journal Year:
2024,
Volume and Issue:
11(3), P. 416 - 442
Published: July 30, 2024
PURPOSE
OF
REVIEW:
Evidence
suggests
neurotoxicity
of
endocrine
disrupting
chemicals
(EDCs)
during
sensitive
periods
development.
We
present
an
overview
pediatric
population
neuroimaging
studies
that
examined
brain
influences
EDC
exposure
prenatal
period
and
childhood.
RECENT
FINDINGS:
found
46
used
magnetic
resonance
imaging
(MRI)
to
examine
EDCs.
These
showed
associations
phthalates,
organophosphate
pesticides
(OPs),
polyaromatic
hydrocarbons
persistent
organic
pollutants
with
global
regional
structural
alterations.
Few
suggested
alteration
in
functional
MRI
associated
OP
exposure.
However,
on
other
groups
EDCs,
such
as
bisphenols,
those
childhood
were
less
conclusive.
findings
underscore
the
potential
profound
lasting
effects
development,
emphasizing
need
for
better
regulation
strategies
reduce
mitigate
impacts.
More
are
needed
influence
postnatal
imaging.
NeuroImage,
Journal Year:
2025,
Volume and Issue:
306, P. 121003 - 121003
Published: Jan. 7, 2025
Although
epigenomic
and
environment
interactions
(Epigenome
×
Environment;
Epi
E)
might
constitute
a
novel
mechanism
underlying
reward
processing
direct
evidence
is
still
scarce.
We
conducted
the
first
longitudinal
study
to
investigate
extent
which
DNA
methylation
of
stress-related
gene-NR3C1-interacts
with
childhood
maltreatment
in
association
young
adult
responsiveness
(RR)
downstream
risk
depressive
(anhedonia
dimension
particular)
anxiety
symptoms.
A
total
192
Chinese
university
students
aged
18∼25
(M
NR3C1-1F
significantly
interacted
on
RewP
but
not
delta
theta
components
or
self-reported
RR.
The
severity
exposure
number
were
negatively
associated
among
individuals
heightened
positively
blunted
demonstrating
"goodness-of-fit"
interaction.
This
interaction
was
specifically
linked
anhedonia
scores
current
findings
provide
preliminary
for
an
E
highlight
cross-level
analyses
electrophysiological
signals
advance
knowledge
biological
foundation
stress-induced
function
relevant
However
caution
should
be
paid
generalizability
these
high-risk
clinical
samples
given
high-functioning
characteristic
present
sample.
Journal of Psychiatry and Neuroscience,
Journal Year:
2025,
Volume and Issue:
50(2), P. E85 - E91
Published: March 4, 2025
Phenomenology
in
anorexia
nervosa
(AN)
appears
to
be
subject
epigenetic
regulation
via
DNA
methylation.
The
micronutrients
B12
and
betaine
contribute
directly
methylation
have
been
shown
abnormally
elevated
blood
samples
from
people
with
AN.
We
measured
plasma
levels,
as
well
leukocyte
among
women
active
AN
(AN-active
group),
those
1-year
remission
(AN-remitted
who
had
never
experienced
an
eating
disorder
(NED
group).
compared
the
groups
on
micronutrient
levels
strength
of
association
between
included
64
AN-active
group,
49
AN-remitted
NED
group.
Relative
(B12:
mean
339.6
[standard
deviation
(SD)
224.3]
μmol/L;
betaine:
33.74
[SD
17.10]
μmol/L),
participants
showed
high
571.0
505.2]
43.73
22.50]
μmol/L);
alone
588.2
379.9]
33.50
19.20]
μmol/L).
There
were
also
group-based
differences
site-specific
at
genes
regulating
insulin
function,
glucose
metabolism,
cell
regulation,
neurotransmitter
function.
These
associations
generally
stronger
without
ED
than
either
or
remitted
extent
which
nutrient
provide
a
meaningful
proxy
cellular
processes
affecting
is
uncertain
sample
size
limits
stability
results.
only
biological
females
this
investigation.
Elevated
resemble
elevations
reported
autoimmune,
neoplastic,
other
disorders.
Such
imply
that
may
misrepresent
nutritional
status
Observed
certain
gene
regions
ambiguous
importance,
but
indicate
influence
mechanisms
coincidence
separate
independently
affect
Clinical Pathology & Research Journal,
Journal Year:
2024,
Volume and Issue:
8(1), P. 1 - 13
Published: Jan. 1, 2024
Previously
we
had
have
reviewed
various
neurodegenerative
diseases
(NDD),
inclusive
of
Alzheimer’s
disease
(AD),
Parkinson’s
(PD),
as
well
Huntington’s
(HD),
role
hydrogen
sulfide
(H2
S),
in
treatment
different
cancers
breast
cancer,
glioma,
hepatocellular
carcinoma
along
with
epigenetics
Diabetic
Kidney
Disease
(DKD),
pregnancy.
There
by
the
objective
this
review
is
provision
an
exhaustive
outline
present
research
controlling
epigenetic
events
correlated
NDD.
Here
conducted
a
narrative
utilizing
search
engine
pubmed,
google
scholar;
web
science;
embase;
Cochrane
library
MeSH
terms
like
(NDD);
;
H2
S
disease;
sulfide;
Epigenetics;
DNA
methylation;
Histone
post-translational
modifications;
protein
acetylation;
methylation
from
2000
till
2023
December
date.
Emerging
proof
has
initiated
unravelling
facets
which
impacts
topography
followed
propagation
NDD
AD,
PD),
HD.
possesses
capacity
modulating
crucial
machinery
for
instance
methylation,
histone
modifications
noncoding
RNAs
influencing
gene
expression
cellular
working
germane
to
neuronal
survival,
neuroinflammation,
synaptic
plasticity.
Thus
it
constructed
how
works
form
imperative
actor
amongst
close-knit
network
possessing
probability
opening
innovative
therapeutic
arena.
Although
considerable
work
done,
still
lot
lacunae
exist
on
exact
molecular
modes
plausible
repercussions
H2S
quantities/its
downstream
targets.
Finally
isolation
future
directions
having
using
Journal of Child Psychology and Psychiatry,
Journal Year:
2023,
Volume and Issue:
65(1), P. 77 - 90
Published: July 19, 2023
Background
Lateral
ventricular
volume
(LVV)
enlargement
has
been
repeatedly
linked
to
schizophrenia;
yet,
what
biological
factors
shape
LVV
during
early
development
remain
unclear.
DNA
methylation
(DNAm),
an
essential
process
for
neurodevelopment
that
is
altered
in
schizophrenia,
a
key
molecular
system
of
interest.
Methods
In
this
study,
we
conducted
the
first
epigenome‐wide
association
study
neonatal
DNAm
cord
blood
with
childhood
(measured
using
T1‐weighted
brain
scans
at
10
years),
based
on
data
from
large
population‐based
birth
cohort,
Generation
R
Study
(
N
=
840).
Employing
both
probe‐level
and
profile
score
(MPS)
approaches,
further
examined
whether
epigenetic
modifications
identified
are:
(a)
also
observed
cross‐sectionally
peripheral
age
years
(Generation
R,
370)
(b)
prospectively
associated
measured
young
adulthood
all‐male
sample
Avon
Longitudinal
Parents
Children
(ALSPAC,
114).
Results
At
birth,
levels
four
CpGs
(annotated
potassium
channel
tetramerization
domain
containing
3,
KCTD3
;
SHH
signaling
ciliogenesis
regulator,
SDCCAG8
glutaredoxin,
GLRX
)
after
genome‐wide
correction;
these
genes
have
implicated
psychiatric
traits
including
schizophrenia.
An
MPS
capturing
broader
–
but
not
individual
top
hits
showed
significant
cross‐sectional
associations
within
ALSPAC.
Conclusions
This
finds
suggestive
evidence
associates
different
life
stages,
albeit
small
effect
sizes.
The
prediction
independent
male
adult
underscores
stability
reproducibility
as
potential
marker
LVV.
Future
studies
larger
samples
comparable
time
points
across
are
needed
elucidate
how
clinically
relevant
structure
risk
neuropsychiatric
disorders,
explain
birth.
