Annual Research Review: Towards a deeper understanding of nature and nurture: combining family‐based quasi‐experimental methods with genomic data
Journal of Child Psychology and Psychiatry,
Journal Year:
2022,
Volume and Issue:
64(4), P. 693 - 707
Published: Nov. 15, 2022
Distinguishing
between
the
effects
of
nature
and
nurture
constitutes
a
major
research
goal
for
those
interested
in
understanding
human
development.
It
is
known,
example,
that
many
parent
traits
predict
mental
health
outcomes
children,
but
causal
processes
underlying
such
associations
are
often
unclear.
Family‐based
quasi‐experimental
designs
as
sibling
comparison,
adoption
extended
family
studies
have
been
used
decades
to
distinguish
genetic
transmission
risk
from
environmental
members
potentially
on
one
another.
Recently,
these
combined
with
genomic
data,
this
combination
fuelling
range
exciting
methodological
advances.
In
review
we
explore
advances
–
highlighting
ways
which
they
applied
date
considering
what
likely
teach
us
coming
years
about
aetiology
intergenerational
psychopathology.
Language: Английский
Using twin-pairs to assess potential bias in polygenic prediction of externalising behaviours across development
Molecular Psychiatry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 19, 2025
Abstract
Prediction
from
polygenic
scores
may
be
confounded
by
sources
of
passive
gene-environment
correlation
(rGE;
e.g.
population
stratification,
assortative
mating,
and
environmentally
mediated
effects
parental
genotype
on
child
phenotype).
Using
genomic
data
10
000
twin
pairs,
we
asked
whether
the
most
recent
externalising
genome-wide
association
study
predict
conduct
problems,
ADHD
symptomology
callous-unemotional
traits,
these
predictions
are
biased
rGE.
We
ran
regression
models
including
within-family
between-family
scores,
to
separate
direct
genetic
influence
a
trait
environmental
influences
that
correlate
with
genes
(indirect
effects).
Findings
suggested
this
score
is
good
index
ADHD-related
symptoms
across
development,
minimal
bias
rGE,
although
predicted
less
variance
in
CU
traits.
Post-hoc
analyses
showed
some
indirect
acting
common
factor
indexing
stability
problems
time
contexts.
Language: Английский
Intergenerational transmission of polygenic predisposition for neuropsychiatric traits on emotional and behavioural difficulties in childhood
Nature Communications,
Journal Year:
2025,
Volume and Issue:
16(1)
Published: March 18, 2025
Abstract
Childhood
emotional
and
behavioural
difficulties
tend
to
co-occur
often
precede
diagnosed
neuropsychiatric
conditions.
Identifying
shared
specific
risk
factors
for
early-life
mental
health
is
therefore
essential
prevention
strategies.
Here,
we
examine
how
parental
shape
their
offspring’s
symptoms
(e.g.
feelings
of
anxiety,
restlessness)
using
data
from
14,959
genotyped
family
trios
the
Norwegian
Mother,
Father
Child
Cohort
Study
(MoBa).
We
model
maternal
reports
symptoms,
organizing
them
into
general
domains.
then
investigate
direct
(genetically
transmitted)
indirect
(environmentally
mediated)
contributions
polygenic
neuropsychiatric-related
traits
whether
these
are
across
symptoms.
observe
evidence
consistent
with
an
environmental
route
symptomatology
beyond
genetic
transmission,
while
also
demonstrating
domain-specific
contributions.
These
findings
improve
our
understanding
early
pathways
that
can
be
targeted
in
preventive
interventions
aiming
interrupt
intergenerational
cycle
transmission.
Language: Английский
Intergenerational transmission of genetic risk for hyperactivity and inattention. Direct genetic transmission or genetic nurture?
JCPP Advances,
Journal Year:
2024,
Volume and Issue:
4(2)
Published: March 4, 2024
Hyperactivity
and
inattention,
the
symptoms
of
ADHD,
are
marked
by
high
levels
heritability
intergenerational
transmission.
Two
distinct
pathways
genetic
transmission
distinguished:
direct
when
parental
variants
passed
to
child's
genome
nurture
background
contributes
outcomes
through
rearing
environment.
This
study
assessed
contributions
hyperactivity
inattention
in
childhood
these
pathways.
Language: Английский
The 20-year documentary of genetic nurturing: The realization of Harris’s insight
Developmental Review,
Journal Year:
2024,
Volume and Issue:
74, P. 101151 - 101151
Published: Oct. 3, 2024
Language: Английский
Research Review: A review of the past decade of family and genomic studies on adolescent mental health
Journal of Child Psychology and Psychiatry,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 19, 2024
Mental
health
problems
and
traits
capturing
psychopathology
are
common
often
begin
during
adolescence.
Decades
of
twin
studies
indicate
that
genetic
factors
explain
around
50%
individual
differences
in
adolescent
psychopathology.
In
recent
years,
significant
advances,
particularly
genomics,
have
moved
this
work
towards
more
translational
findings.
Language: Английский
The Mechanisms Underlying the Intergenerational Transmission of Substance Use and Misuse: An Integrated Research Approach
Twin Research and Human Genetics,
Journal Year:
2024,
Volume and Issue:
unknown, P. 1 - 12
Published: Dec. 23, 2024
Abstract
Substance
use
and
substance
disorders
run
in
families.
While
it
has
long
been
recognized
that
the
etiology
of
behaviors
involves
a
combination
genetic
environmental
factors,
two
key
questions
remain
largely
unanswered:
(1)
intergenerational
transmission
through
which
these
predispositions
are
passed
from
parents
to
children,
(2)
molecular
mechanisms
linking
variants
disorders.
This
article
aims
provide
comprehensive
conceptual
framework
methodological
approach
for
investigating
disorders,
by
integrating
nurture
analysis,
gene
expression
imputation,
weighted
co-expression
network
analysis.
We
also
additionally
describe
longitudinal
cohorts
—
Brisbane
Longitudinal
Twin
Study
Australia
Lifelines
Cohort
Netherlands.
By
applying
unique
datasets,
our
future
research
will
explore
complex
interplay
between
expression,
influences
on
across
different
life
stages
populations.
Language: Английский