Clinicopathological Insights to the Nerve Growth Factor NGF Associated Stress Response in Pregnancy and Therapeutic Potential in Fetal Neurodevelopment DOI

Tayyaba Siddique,

Seerat Ul Urooj Bhutto,

Naweed I. Syed

et al.

Pakistan Journal of Health Sciences, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 30, 2024

The nerve growth factor has a significant role in fetal neurogenesis and sustaining pregnancy. Objectives: To investigate the effects of stress response during pregnancy on developing fetus to bring clinicopathological correlation maternal markers (cortisol levels, glucocorticoids, depression, anxiety, brain-derived neurotrophic levels) brain development. Methods: Following PRISMA guidelines, this study was extracted from PubMed, ScienceDirect, Nature, Google Scholar articles January 2014 April 2024. examination pregnant women published research gave possibility understand application as suitable biomarker for neuronal exclude studies with lower ranks, each selected assessed adherence evidence-based methodology. were taken China, Europe, America South Asia (including Pakistan). Results: Increased levels associated reactions which caused changes cortisol amygdaloidal complex area. However, increased level linked such weight biomarkers amniotic fluid sample inferring critical modulation neurodevelopmental spheres. Conclusions: It concluded that it is important note how factors interact create effective interventions reduce dependence better health both mother child.

Language: Английский

Enduring Neurobiological Consequences of Early-Life Stress: Insights from Rodent Behavioral Paradigms DOI Creative Commons
Luisa Speranza, Kardelen Dalım Filiz, Pellegrino Lippiello

et al.

Biomedicines, Journal Year: 2024, Volume and Issue: 12(9), P. 1978 - 1978

Published: Sept. 2, 2024

Stress profoundly affects physical and mental health, particularly when experienced early in life. Early-life stress (ELS) encompasses adverse childhood experiences such as abuse, neglect, violence, or chronic poverty. These stressors can induce long-lasting changes brain structure function, impacting areas involved emotion regulation, cognition, response. Consequently, individuals exposed to high levels of ELS are at an increased risk for health disorders like depression, anxiety, post-traumatic disorders, well issues, including metabolic cardiovascular disease, cancer. This review explores the biological psychological consequences early-life adversity paradigms rodents, maternal separation deprivation limited bedding nesting. The study these experimental models have revealed that organism’s response is complex, involving genetic epigenetic mechanisms, associated with dysregulation physiological systems nervous, neuroendocrine, immune systems, a sex-dependent fashion. Understanding impact crucial developing effective interventions preventive strategies humans stressful traumatic childhood.

Language: Английский

Citations

7
Social Isolation during Pregnancy Disrupts Maternal Behavior and Hippocampal Neurochemistry in Rats: A Role for BDNF, Corticosterone, and GABAARα1 DOI Creative Commons
Samira Khayat, Hamed Fanaei, Kambiz Bagheri

et al.

Comprehensive Psychoneuroendocrinology, Journal Year: 2025, Volume and Issue: 21, P. 100282 - 100282

Published: Jan. 15, 2025

Language: Английский

Citations

1
Association of early pregnancy telomere length and mitochondrial copy number with gestational diabetes mellitus and depressive symptoms DOI
Chinnasamy Thirumoorthy,

Rashmi Rekha,

Mohan Deepa

et al.

Psychoneuroendocrinology, Journal Year: 2025, Volume and Issue: unknown, P. 107431 - 107431

Published: March 1, 2025

Language: Английский

Citations

1
Advances in fetal and neonatal neuroimaging and everyday exposures DOI Creative Commons
Alexandra Lautarescu, Alexandra F. Bonthrone, Brendan Bos

et al.

Pediatric Research, Journal Year: 2024, Volume and Issue: 96(6), P. 1404 - 1416

Published: June 14, 2024

Abstract The complex, tightly regulated process of prenatal brain development may be adversely affected by “everyday exposures” such as stress and environmental pollutants. Researchers are only just beginning to understand the neural sequelae exposures, with advances in fetal neonatal neuroimaging elucidating structural, microstructural, functional correlates developing brain. This narrative review discusses wide-ranging literature investigating influence parental on well emerging assessing impact exposure toxicants lead air pollution. These ‘everyday exposures’ can co-occur other stressors social financial deprivation, therefore we include a brief discussion studies effect disadvantage. Increased is associated alterations structure, microstructure function, some evidence these associations moderated factors infant sex. However, most examine single exposures relationship between utero pollutants or sparse. Large cohort required that evaluation multiple co-occurring order fully characterize their early development. Impact altered functional, macro microstructural Exposure pollution also alter period. Further research needed investigate including stress, toxicants, socioeconomic deprivation

Language: Английский

Citations

5
Enhancing brain health in the global south through a sex and gender lens DOI

Sandra Baez,

Laura Castro‐Aldrete,

Gabrielle B. Britton

et al.

Nature Mental Health, Journal Year: 2024, Volume and Issue: 2(11), P. 1308 - 1317

Published: Oct. 28, 2024

Language: Английский

Citations

5
Association between maternal perinatal stress and depression and infant DNA methylation in the first year of life DOI Creative Commons
Sarina Abrishamcar, Beryl Zhuang, Mara Thomas

et al.

Translational Psychiatry, Journal Year: 2024, Volume and Issue: 14(1)

Published: Oct. 22, 2024

Maternal stress and depression during pregnancy the first year of infant's life affect a large percentage mothers. have been associated with adverse fetal childhood outcomes as well differential child DNA methylation (DNAm). However, biological mechanisms connecting maternal to poor health in children are still largely unknown. Here we aim determine whether prenatal differences cord blood mononuclear cell DNAm (CBMC-DNAm) newborns (n = 119) postnatal peripheral (PBMC-DNAm) 12 months age 113) from Canadian Healthy Infant Longitudinal Development (CHILD) cohort. Stress was measured using 10-item Perceived Scale (PSS) 20-item Center for Epidemiologic Studies Depression Questionnaire (CESD). Both were longitudinally at 18 weeks 36 six postpartum. We conducted epigenome-wide association studies (EWAS) robust linear regression followed by sensitivity analysis which bias-adjusted inflation unmeasured confounding bacon cate methods. To quantify cumulative effect depression, created composite adversity scores. identified significant between CBMC-DNAm 8 CpG sites 2 sites. Additionally, PBMC-DNAm 11 Using our scores, further significantly 7 adversity. Several genes, including PLAGL1, HYMAI, BRD2, ERC2 implicated neuropsychiatric disorders. These data support finding that may play role relationship mental health.

Language: Английский

Citations

4
Functional Connectivity to the Amygdala in the Neonate Is Impacted by the Maternal Anxiety Level During Pregnancy DOI Open Access
Trenesha L. Hill, Xiaoxu Na,

Jayne Bellando

et al.

Journal of Neuroimaging, Journal Year: 2025, Volume and Issue: 35(1)

Published: Jan. 1, 2025

ABSTRACT Background and Purpose Anxiety during pregnancy is common, exposure to heightened anxiety may influence children's brain development functioning. However, it unclear if low levels of in utero would also impact the developing brain. The current prospective longitudinal study included 40 healthy pregnant women without complications or previous diagnosis disorders. Methods Pregnant women's symptoms were measured at 12, 24, 36 weeks gestation. Their healthy, full‐term offspring underwent a MRI scan sedation, including resting‐state functional MRI, 2 postnatal age. associations between neonatal cortical connectivity originating from amygdala maternal prenatal symptom scores examined using correlational analyses. Results Significant correlations identified after controlling for child sex, postmenstrual age mother's depression scores. Higher was related alterations offspring's other regions involved fear learning. Specifically, higher first trimester associated with lower fusiform gyrus thalamus. third gyrus. Conclusions findings this indicate that functioning, particularly are important threat detection.

Language: Английский

Citations

0
Protocol for a Randomized Controlled Trial of the Mommy&Me Study: A Multi-Modal Approach to Address Social Determinants of Health and Mental Health Among Low-Income Black Perinatal Populations DOI
Huynh‐Nhu Le, Nickie Andescavage,

Jennifer M. Keller

et al.

Published: Jan. 1, 2025

Language: Английский

Citations

0
From Molecules to Mind: The Critical Role of Chitosan, Collagen, Alginate, and Other Biopolymers in Neuroprotection and Neurodegeneration DOI Creative Commons
Weronika Kruczkowska, Julia Gałęziewska,

Katarzyna Grabowska

et al.

Molecules, Journal Year: 2025, Volume and Issue: 30(5), P. 1017 - 1017

Published: Feb. 22, 2025

Neurodegenerative disorders present significant therapeutic challenges, particularly due to the complex nature of drug delivery central nervous system. This review investigates applications various biopolymers in neuroprotection and their potential role treating neurodegeneration. We a critical analysis natural synthetic biopolymers, focusing primarily on chitosan, fish collagen/gelatin, alginate as key agents. The examines fundamental mechanisms brain development neurodegeneration, establishing framework for understanding how these interact with neural tissues. By analyzing recent experimental studies, we evaluate effectiveness different biopolymer-based systems crossing blood-brain barrier subsequent neuroprotective effects. Additionally, promising materials, including lignin, poly lactic-co-glycolic acid, glucose-modified bovine serum albumin/procyanidin complexes, are briefly explored provide comprehensive overview current developments field. Our reveals that approaches offer unique advantages both delivery, potentially opening new avenues neurodegenerative conditions. synthesizes knowledge identifies directions future research strategies.

Language: Английский

Citations

0
Depletion of Fkbp5 Protects Against the Rapid Decline in Ovarian Reserve Induced by Prenatal Stress in Female Offspring of Wild-Type Mice DOI Open Access

Monica Moore,

Busra Cetinkaya-Un, Papri Sarkar

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(6), P. 2471 - 2471

Published: March 10, 2025

Prenatal stress (PNS) impairs offspring ovarian development by exerting negative long-term effects on postnatal function and folliculogenesis. FKBP51 is a stress-responsive protein that inhibits glucocorticoid progesterone receptors. We hypothesize contributes to impaired folliculogenesis induced PNS. Timed-pregnant Fkbp5+/+ (wild-type) Fkbp5−/− (knockout) mice were randomly assigned either the undisturbed (nonstress) or PNS group, with exposure maternal restraint from embryonic days 8 18. Ovaries harvested stained, follicles counted according their stages. Ovarian expressions of evaluated immunohistochemistry Fkbp5 steroidogenic enzymes qPCR. Compared controls, had increased peripubertal primordial follicle atresia fewer total in adult middle-aged groups. In offspring, elevated levels granulosa cells primary tertiary follicles. Our results suggest administration levels, depleted reserve, dysregulated steroid synthesis. However, these tolerated mice, supporting conclusion reduced reserve

Language: Английский

Citations

0