Morphometric brain organization across the human lifespan reveals increased dispersion linked to cognitive performance

PLoS Biology, Journal Year: 2024, Volume and Issue: 22(6), P. e3002647 - e3002647

Published: June 20, 2024

The human brain is organized as segregation and integration units follows complex developmental trajectories throughout life. cortical manifold provides a new means of studying the brain’s organization in multidimensional connectivity gradient space. However, how morphometric changes across lifespan remains unclear. Here, leveraging structural magnetic resonance imaging scans from 1,790 healthy individuals aged 8 to 89 years, we investigated age-related global, within- between-network dispersions reveal networks 3D manifolds based on similarity network (MSN), combining multiple features conceptualized “fingerprint” an individual’s brain. Developmental global dispersion unfolded along patterns molecular organization, such acetylcholine receptor. Communities were increasingly dispersed with age, reflecting more disassortative profiles within community. Increasing within-network primary motor association cortices mediated influence age cognitive flexibility executive functions. We also found that secondary sensory decreasingly rest during aging, possibly indicating shift extreme central position manifolds. Together, our results MSN perspective space, providing insights into brain, well performance.

Language: Английский

---

Genetically informed disassortative brain morphometric similarities revealing suicide risk in bipolar disorder

Biological Psychiatry Cognitive Neuroscience and Neuroimaging, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

---

Major depressive disorder on a neuromorphic continuum

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: March 11, 2025

The heterogeneity of major depressive disorder (MDD) has hindered clinical translation and neuromarker identification. Biotyping facilitates solving the problems heterogeneity, by dissecting MDD patients into discrete subgroups. However, interindividual variations suggest that depression may be conceptualized as a "continuum," rather than "category." We use Bayesian model to decompose structural MRI features from multisite cross-sectional cohort three latent disease factors (spatial pattern) continuum factor compositions (individual expression). are associated with distinct neurotransmitter receptors/transporters obtained open PET sources. Increases cortical thickness in sensory decreases orbitofrontal cortices (Factor 1) associate norepinephrine 5-HT2A density, cingulo-opercular network subcortex 2) 5-HTT increases social affective brain systems 3) relate density. Disease patterns can also used predict symptom improvement longitudinal cohort. Moreover, individual expressions stable over time cohort, differentially expressed controls transdiagnostic Collectively, our data-driven reveal organize along continuous dimensions affect sets regions. Li et al. identify abnormalities using an unsupervised machine learning technique, quantify their expression level for each patient.

Language: Английский

---

Chemoarchitectural signatures of subcortical shape alterations in generalized epilepsy

Communications Biology, Journal Year: 2024, Volume and Issue: 7(1)

Published: Aug. 20, 2024

Genetic generalized epilepsies (GGE) exhibit widespread morphometric alterations in the subcortical structures. Subcortical structures are essential for understanding GGE pathophysiology, but their fine-grained morphological diversity has yet to be comprehensively investigated. Furthermore, relationships between macroscale disturbances and microscale molecular chemoarchitectures unclear. High-resolution structural images were acquired from patients with (n = 97) sex- age-matched healthy controls (HCs, n 184). Individual measurements of surface shape features (thickness area) seven bilateral quantified. The HCs then compared vertex-wise, anomalies co-located brain neurotransmitter profiles. We found prominent disruptions thalamus, putamen, hippocampus. Shape area dilations observed ventral, medial, right dorsal as well lateral putamen. that deviation pattern was spatially correlated norepinephrine transporter nicotinic acetylcholine (Ach) receptor (α

Language: Английский

---

Inflammation-related abnormal dynamic brain activity correlates with cognitive impairment in first-episode, drug-naïve major depressive disorder

Journal of Affective Disorders, Journal Year: 2024, Volume and Issue: 366, P. 217 - 225

Published: Aug. 27, 2024

Language: Английский

---