Correlates of Risk for Disinhibited Behaviors in the Million Veteran Program Cohort DOI Creative Commons
Peter B. Barr, Tim B. Bigdeli, Jacquelyn L. Meyers

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: March 25, 2023

ABSTRACT Background Many psychiatric outcomes are thought to share a common etiological pathway reflecting behavioral disinhibition, generally referred as externalizing disorders (EXT). Recent genome-wide association studies (GWAS) have demonstrated the overlap between EXT and important aspects of veterans’ health, such suicide-related behaviors, substance use disorders, other medical conditions. Methods We conducted series phenome-wide (PheWAS) polygenic scores (PGS) for EXT, comorbid problems (depression, schizophrenia, suicide attempt) in an ancestrally diverse cohort U.S. veterans ( N = 560,824), using diagnostic codes from electronic health records. ancestry-specific PheWASs PGS European, African, Hispanic/Latin American ancestries. To determine if associations were driven by risk problems, we performed conditional PheWAS, covarying (European ancestries only). Lastly, adjust unmeasured confounders within-family analysis significant main PheWAS full-siblings (N 12,127, European Results The was associated with 619 across all bodily systems, which, 188 independent PGS. Effect sizes ranged OR 1.02 (95% CI 1.01, 1.03) overweight/obesity 1.44 1.42, 1.47) viral hepatitis C. Of 73 (11.9%) 26 (4.5%) African results, respectively. Within-family analyses uncovered robust consequences including liver disease, chronic airway obstruction, Conclusion Our results demonstrate shared basis populations problems. strongest diagnoses related their sequelae. Overall, highlight potential negative functioning US veteran population.

Language: Английский

Distinguishing clinical and genetic risk factors for suicidal ideation and behavior in a diverse hospital population DOI Creative Commons
Sarah M. C. Colbert, Lauren Lepow, Brian Fennessy

et al.

Translational Psychiatry, Journal Year: 2025, Volume and Issue: 15(1)

Published: Feb. 20, 2025

Suicidal ideation (SI) and behavior (SB) are major public health concerns, but risk factors for their development progression poorly understood. We used ICD codes a natural language processing algorithm to identify individuals in hospital biobank with SI-only, SB, controls without either. compared the profiles of SB SI-only patients controls, each other, using phenome-wide association studies (PheWAS) polygenic scores (PRS). PheWAS identified many plus specific psychiatric disorders which may be involved from SB. PRS suicide attempt were only associated even after accounting disorder PRS. SI although not These findings advance understanding distinct genetic clinical will aid early detection intervention efforts.

Language: Английский

Citations

0
Suicidal Behavior in Patients with Schizophrenia and Schizophrenia Spectrum Disorders: A Review of Studies in the Russian Population DOI Creative Commons

Olga N Patrikeeva,

Ya. V. Mokhnacheva,

А.О. Кибитов

et al.

Psikhiatriya, Journal Year: 2025, Volume and Issue: 22(6), P. 89 - 102

Published: Feb. 25, 2025

Background: suicide is one of the significant causes death in patients with schizophrenia and spectrum disorders (SSD). The development effective methods for prevention suicidal behavior an urgent scientific practical problem psychiatric practice. There known variability rates suffering from these diseases, associated ethnic, cultural economic characteristics different countries. Despite a number foreign publications devoted to this problem, there shortage correct up-to-date data on situation Russian population. As result, assessing current making forecasts within framework building long-term programs difficult. aim was systematize generalize published results studies SSD. Material Methods: search Russian-language articles carried out eLibrary.ru database. When searching articles, combinations keywords “schizophrenia”, “schizophrenia disorders” “suicidal behavior” were used. Data used comparison obtained by PubMed electronic database using combination “meta-analysis”, “mental disorders”; “suicide” various combinations. Discussion: analysis indicates that are no large-scale at regional or national level aimed studying SSD Federation. available sparse contradictory, agreement other populations not high. A important limitations (small sample sizes, controversial study designs) make it difficult extrapolate entire Conclusions: use population should be done caution. It seems necessary conduct Russia. such will demand both research purposes, primarily organizing measures reduce risk among levels.

Language: Английский

Citations

0
Relationship of Perceived Burdensomeness and Thwarted Belongingness to Suicide Ideation Persistence and Suicide Behavior Over 12 Months in People With Serious Mental Illness DOI
Emma M. Parrish, Kevin S. Kuehn, Amy E. Pinkham

et al.

Schizophrenia Bulletin, Journal Year: 2025, Volume and Issue: unknown

Published: March 14, 2025

Abstract Background and Hypothesis People with serious mental illness (SMI) have an increased risk of suicide ideation (SI) behavior (SB). Longitudinal studies on factors contributing to SI/SB in SMI are lacking. Interpersonal biases (ie, perceived burdensomeness thwarted belongingness) cross-sectionally related SI/SB, but do they relate longitudinal or other factors? Ecological momentary assessment (EMA) offers a powerful approach deeper understanding these complex relationships. Study Design Participants (N = 180) completed 3 in-lab visits (baseline, 6-month, 12-month) 10 days EMA (3×/day) following the baseline visit. At all timepoints, participants were assessed for classified as persistent, intermittent, no SI any reports SB over 12-month follow-up. Multinomial logistic regression models examined whether burdensomeness, belongingness, social motivations, psychotic symptoms predicted persistence 12 months. Time-series network analysis compared participants’ data by SI. Results Burdensomeness belongingness persistent months, did voices, suspiciousness, motivations. Only Network analyses revealed unique lagged relationships group: suspiciousness avoidance motivation when group without Conclusions These findings indicate importance interpersonal trajectories months SMI. Pending replication, constructs may be potential prevention treatment targets

Language: Английский

Citations

0
Defining Suicidal Thought and Behavior Phenotypes for Genetic Studies DOI Creative Commons
Eric T. Monson, Sarah M. C. Colbert, Ole A. Andreassen

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: July 29, 2024

Abstract Background Standardized definitions of suicidality phenotypes, including suicidal ideation (SI), attempt (SA), and death (SD) are a critical step towards improving understanding comparison results in suicide research. The complexity contributes to heterogeneity phenotype definitions, impeding evaluation clinical genetic risk factors across studies efforts combine samples within consortia. Here, we present expert data-supported recommendations for defining control phenotypes facilitate merging current/legacy with definition variability aid future sample creation. Methods A subgroup clinician researchers experts from the Suicide Workgroup Psychiatric Genomics Consortium (PGC) reviewed existing PGC SI, SA, SD, groups generated preliminary consensus guidelines instrument-derived international classification disease (ICD) data. ICD lists were validated two independent datasets (N = 9,151 12,394). Results Recommendations provided evaluated instruments SA emphasizing selection lifetime measures phenotype-specific wording. also SI SD As is complex, code list against instrument sensitivity (range 15.4% 80.6%), specificity 67.6% 97.4%), positive predictive values 0.59-0.93) reported. Conclusions Best-practice presented use information define SI/SA/SD consortia These proposed expected more homogeneous data aggregation multisite studies. Future research should involve refinement, improved generalizability, validation diverse populations.

Language: Английский

Citations

2
Molecular Changes Associated with Suicide DOI Open Access
Daniela Navarro, Marta Marín-Mayor, Ani Gasparyan

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(23), P. 16726 - 16726

Published: Nov. 24, 2023

Suicide is a serious global public health problem, with worrying recent increase in suicide rates both adolescent and adult populations. However, it essential to recognize that preventable. A myriad of factors contributes an individual's vulnerability suicide. These include various potential causes, from psychiatric disorders genetic epigenetic alterations. changes can induce dysfunctions crucial systems such as the serotonergic, cannabinoid, hypothalamic-pituitary-adrenal axes. In addition, early life experiences abuse profoundly impact ability cope stress, ultimately leading inflammatory system, which significant risk factor for suicidal behavior. Thus, clear behavior may result confluence multiple factors. This review examines primary associated behavior, including disorders, adversities, modifications. Our goal elucidate molecular at genetic, epigenetic, levels brains individuals who have taken their own lives plasma peripheral mononuclear cells attempters how these serve predisposing tendencies.

Language: Английский

Citations

3
Correlates of Risk for Disinhibited Behaviors in the Million Veteran Program Cohort DOI
Peter B. Barr, Tim B. Bigdeli, Jacquelyn L. Meyers

et al.

JAMA Psychiatry, Journal Year: 2023, Volume and Issue: 81(2), P. 188 - 188

Published: Nov. 8, 2023

Importance Many psychiatric outcomes share a common etiologic pathway reflecting behavioral disinhibition, generally referred to as externalizing (EXT) disorders. Recent genome-wide association studies (GWASs) have demonstrated the overlap between EXT disorders and important aspects of veterans’ health, such suicide-related behaviors substance use (SUDs). Objective To explore correlates risk for within Veterans Health Administration (VA) Million Veteran Program (MVP). Design, Setting, Participants A series phenome-wide (PheWASs) polygenic scores (PGSs) was conducted using electronic health records. First, ancestry-specific PheWASs PGSs were in African, European, Hispanic or Latin American ancestries. Next, conditional PheWAS, covarying comorbid problems (depression, schizophrenia, suicide attempt; European ancestries only), performed. Lastly, adjust unmeasured confounders, within-family analysis significant associations from main PheWAS performed full siblings (European only). This study included record data US veterans VA care centers enrolled MVP. Analyses took place February 2022 August 2023 covering period October 1999 January 2020. Exposures EXT, depression, attempt. Main Outcomes Measures Phecodes diagnoses derived International Statistical Classification Diseases , Ninth Tenth Revisions Clinical Modification codes Results Within MVP (560 824 patients; mean [SD] age, 67.9 [14.3] years; 512 593 male [91.4%]), PGS associated with 619 outcomes, which 188 independent (from odds ratio [OR], 1.02; 95% CI, 1.01-1.03 overweight/obesity OR, 1.44; 1.42-1.47 viral hepatitis C). Of 73 (11.9%) African results 26 (4.5%) results. Within-family analyses uncovered robust consequences SUDs, including liver disease, chronic airway obstruction, C. Conclusions Relevance this cohort suggest shared basis disorders, other problems. In addition, found related SUDs their sequelae. Overall, highlighted potential negative functioning veteran population.

Language: Английский

Citations

1
The Impact of Selection Bias on Genetic Prediction Using the Bipolar Polygenic Risk Score in First-Admission Psychosis DOI
Katherine Jonas,

Amna Asim,

Yuan Yang

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: July 16, 2024

Abstract Polygenic risk scores (PRS) have potential utility as biomarkers of psychiatric disorders. However, while the schizophrenia (SZ) PRS has been consistently associated with case-control status and a more severe course illness, associations between bipolar (BP) markers disorder vary considerably studies, studies population samples identifying many effects that cannot be replicated in case-only analyses. These analyses demonstrate heterogeneity BP is driven by selection bias. Specifically, selecting on basis diagnostic or other phenotypes genetic attenuates correlation SZ PRS. In such high-severity samples, predicts poor outcomes, better outcomes. findings highlight importance understanding impact bias translational research evaluating disorders, particularly when intended application populations enriched for high levels risk.

Language: Английский

Citations

0
Distinguishing clinical and genetic risk factors for suicidal ideation and behavior in a diverse hospital population DOI Creative Commons
Sarah M. C. Colbert, Lauren Lepow, Brian Fennessy

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 2, 2024

Suicidal ideation (SI) and behavior (SB) are major public health concerns, but risk factors for their development progression poorly understood. We used ICD codes a natural language processing algorithm to identify individuals in hospital biobank with SI-only, SB, controls without either. compared the profiles of SB SI-only patients controls, each other, using phenome-wide association studies (PheWAS) polygenic scores (PRS). PheWAS identified many plus specific psychiatric disorders which may be involved from SB. PRS suicide attempt were only associated even after accounting disorder PRS. SI although not These findings advance understanding distinct genetic clinical will aid early detection intervention efforts.

Language: Английский

Citations

0
Correlates of Risk for Disinhibited Behaviors in the Million Veteran Program Cohort DOI Creative Commons
Peter B. Barr, Tim B. Bigdeli, Jacquelyn L. Meyers

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: March 25, 2023

ABSTRACT Background Many psychiatric outcomes are thought to share a common etiological pathway reflecting behavioral disinhibition, generally referred as externalizing disorders (EXT). Recent genome-wide association studies (GWAS) have demonstrated the overlap between EXT and important aspects of veterans’ health, such suicide-related behaviors, substance use disorders, other medical conditions. Methods We conducted series phenome-wide (PheWAS) polygenic scores (PGS) for EXT, comorbid problems (depression, schizophrenia, suicide attempt) in an ancestrally diverse cohort U.S. veterans ( N = 560,824), using diagnostic codes from electronic health records. ancestry-specific PheWASs PGS European, African, Hispanic/Latin American ancestries. To determine if associations were driven by risk problems, we performed conditional PheWAS, covarying (European ancestries only). Lastly, adjust unmeasured confounders within-family analysis significant main PheWAS full-siblings (N 12,127, European Results The was associated with 619 across all bodily systems, which, 188 independent PGS. Effect sizes ranged OR 1.02 (95% CI 1.01, 1.03) overweight/obesity 1.44 1.42, 1.47) viral hepatitis C. Of 73 (11.9%) 26 (4.5%) African results, respectively. Within-family analyses uncovered robust consequences including liver disease, chronic airway obstruction, Conclusion Our results demonstrate shared basis populations problems. strongest diagnoses related their sequelae. Overall, highlight potential negative functioning US veteran population.

Language: Английский

Citations

0