Plasma and CSF neurofilament light chain distinguish neurodegenerative from primary psychiatric conditions in a clinical setting

Alzheimer s & Dementia, Journal Year: 2024, Volume and Issue: 20(11), P. 7989 - 8001

Published: Oct. 6, 2024

Abstract INTRODUCTION People with neurodegenerative disorders (ND) frequently face diagnostic delay and misdiagnosis. We investigated blood cerebrospinal fluid (CSF) neurofilament light chain (NfL) to distinguish ND from primary psychiatric (PPD), a common challenge in clinical settings. METHODS Plasma CSF NfL levels were measured compared between groups, adjusting for age, sex, weight. RESULTS A total of 337 participants included: 136 ND, 77 PPD, 124 Controls. was 2.5‐fold elevated PPD had strong performance (area under the curve, [AUC]: 0.86, 81%/85% specificity/sensitivity) that comparable (2‐fold elevated, AUC: 0.89, 95%/71% specificity/sensitivity). Diagnostic especially younger people (40– < 60 years). Additional findings cutoffs optimized sensitivity specificity, issues important future translation. CONCLUSIONS This study adds evidence simple blood‐based biomarker assist as screening test neurodegeneration distinction Highlights significantly higher versus PPD. showed performance, NfL, people, where challenges are greater. Further research is needed on analytical reference range factors, These support neurodegeneration.

Language: Английский

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Plastic harmful ingredients reduce the level of neurofilament light chain protein

Ecotoxicology and Environmental Safety, Journal Year: 2025, Volume and Issue: 289, P. 117670 - 117670

Published: Jan. 1, 2025

Population exposure to plastics is increasing, and plasticizers are frequently detected in humans as important ingredients of plastic products. However, patterns harmful their effects on neurofilament light chain (NFL), a marker active brain pathology, currently inconclusive. Herein, we employed range statistical methods thoroughly investigate the impact 24 hazardous varying NFL concentrations blood general population 533 participants. Generalized linear model revealed positive correlation between Mono-isononyl phthalate Mono (2-Ethyl- 5-Hydroxyhexyl) Phthalate (MEHHP) with NFL. Furthermore, significant dose-response relationship was observed MEHHP NFL, while Butyl paraben (Hydroxy-Isononyl) Ester exhibited distinct "inverted U-shaped" nonlinear pattern Additionally, Weighted Quantile Sum allowed us identify mixed all ingredients, Mono(2-Ethyl-5-Oxohexyl) Phthalate, Mono-isobutyl phthalate, Mon butyl Propyl Triclosan occupying prominent positions. Finally, latent profile analysis categorized exposures into high, medium, low patterns, confirming that higher posed risk factor for elevated levels blood. Exposure significantly increases present contributes early detection intervention reduce incidence neurodevelopmental disorder.

Language: Английский

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Establishing Decisional Cutoff Values of Neurofilament Light Chains in Cerebrospinal Fluid Measured by Fully Automated Chemiluminescent Enzyme Immunoassay

Journal of Clinical Laboratory Analysis, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 15, 2025

Neurofilament light chain (NfL) is one of the most important biomarkers in field clinical neurochemistry. Several analytical methods have been developed last decade. Recently, Fujirebio introduced a ready-to-use assay kit for measuring NfL levels cerebrospinal fluid (CSF) on fully automated LUMIPULSE G System. In this study, we established decisional cutoffs CSF NfL. We performed retrospective observational study including patients with cognitive decline. were measured by two methods: NF-light ELISA (UmanDiagnostics) and Lumipulse G1200 system (Fujirebio). calculated Lumipulse, starting from consolidated method each age using equation obtained regression analysis. The population consisted 100 median 776.5 ± 772.6 pg/mL 473.5 443.5 pg/mL, respectively, significantly different (p < 0.001). Spearman's rank correlation coefficient was 0.962, indicating robust positive between measurement methods. derived Passing-Bablok analysis CLEIA = -61.16 + 1.83 × ELISA. Based equation, defined cutoff values. Decisional are fundamental tools guiding clinicians to use biomarkers' results interpretation appropriately. This first establishing value platform widely used laboratories.

Language: Английский

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The moderating effect of diet on the relationship between depressive symptoms and Alzheimer’s disease-related blood-based biomarkers

Neurobiology of Aging, Journal Year: 2025, Volume and Issue: 147, P. 213 - 222

Published: Jan. 15, 2025

Language: Английский

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Serum NFL and neuropsychological performance over ∼8 years in women with and without HIV: a longitudinal repeated measures study

EClinicalMedicine, Journal Year: 2025, Volume and Issue: 80, P. 103052 - 103052

Published: Jan. 21, 2025

Language: Английский

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Neurofilament Light Chain in Cerebrospinal Fluid and Blood in Multiple System Atrophy: A Systematic Review and Meta-Analysis

Brain Sciences, Journal Year: 2025, Volume and Issue: 15(3), P. 241 - 241

Published: Feb. 25, 2025

Background/Objectives: Multiple system atrophy (MSA) presents a challenging diagnosis due to its clinical overlap with other neurodegenerative disorders, especially α-synucleinopathies. The main purpose of this systematic review and meta-analysis was assess neurofilament light chain (NfL) differences in the CSF blood patients MSA versus healthy control group (HC), Parkinson’s disease (PD) Lewy body dementia (LBD). Secondarily, diagnostic metrics circulating NfL HC, PD, LBD, progressive supranuclear palsy (PSP) corticobasal degeneration (CBD) were discussed. Methods: MEDLINE EMBASE thoroughly searched for relevant case-control studies. Standardized mean (SMDs) calculated separately per comparison. Statistical heterogeneity assessed based on Q I^2 statistics. Results: Twenty-five studies retrieved. Quantitative syntheses revealed elevated levels individuals HC [SMD = 1.80 (95%CI 1.66, 1.94) SMD 2.00 1.36, 2.63), respectively] PD 1.65 1.26, 2.03) 1.63 0.84, 2.43), as well LBD 1.17, 0.71, 1.63) 0.65 0.30, 1.00), respectively]. Diagnostic accuracy outstanding it moderate LBD. On hand, suboptimal vs. PSP CBD. Conclusions: Both are compared To achieve optimal properties, further work is required standardization processes establishment reference intervals and/or thresholds.

Language: Английский

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Transient Global Amnesia (TGA): Is It Really Benign? A Pilot Study on Blood Biomarkers

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(6), P. 2629 - 2629

Published: March 14, 2025

We aimed to determine whether transient global amnesia (TGA) is associated with alterations in central nervous system (CNS) injury biomarkers—serum neurofilament light chain (sNfL) and serum glial fibrillary acidic protein (sGFAP). In a prospective cohort of TGA patients, blood samples were obtained within 24–48 h onset (t0) 6 weeks thereafter (t1). assessed sNfL sGFAP levels using the highly sensitive single-molecule array assay calculated Z-scores adjusted for age, gender, body mass index (BMI). Demographics, electroencephalography (EEG), cerebral magnetic resonance imaging (cMRI) findings also collected. A total 20 patients included (median age: 66 years, 70% women). No significant changes or at t0 t1 observed. Median 0.45 (interquartile range [IQR] −0.09, 1.19) 0.60 (IQR −0.61, t1. 0.27 −0.45, 0.76) 0.44 −0.27, 0.75) Similarly, subgroup diffusion-weighted (DWI)-positive hippocampal lesions (n = 5/20[25%]), no elevations biomarkers detected. Our pilot study on neurological supports benign nature TGA, indicating that CNS tissue damage occurs.

Language: Английский

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Neurofilament light chain as a biomarker for neurodegenerative changes in COVID-19 and clinical implications

Future Virology, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 15

Published: March 21, 2025

Language: Английский

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Plasma Glial Fibrillary Acidic Protein and Neurofilament Light Are Elevated in Bipolar Depression: Evidence for Neuroprogression and Astrogliosis

Bipolar Disorders, Journal Year: 2025, Volume and Issue: unknown

Published: April 23, 2025

ABSTRACT Background Recent advances now allow detection of brain‐specific proteins in blood, including neurofilament light chain (NfL), a marker axonal pathology, and glial fibrillary acidic protein (GFAP), indicative astrocytic activation. Given the evidence astroglial pathology neuronal dysfunction bipolar disorder, ongoing debates on neuroprogression, we investigated plasma NfL GFAP levels affected individuals. Methods This study analysed measured 216 individuals using Simoa. We used bootstrapped general linear models (GLM) to compare between people with depression ( n = 120) healthy controls 96), adjusting for age, sex, weight. examined associations these biomarkers clinical variables while multiple comparisons. For sensitivity analyses, predictors were evaluated Bayesian model averaging (BMA). Results Plasma β 0.21 [0.07, 0.35], p 0.006) 0.06 [0.01, 0.10], 0.028) elevated depression. Illness duration was positively associated r 2.97, 0.002), further supported by BMA analysis (posterior inclusion probability, PIP 0.85). Age onset 0.246 0.041), which also (PIP 0.67). Conclusions These findings indicate increased disorder. Our support neuroprogression hypothesis, where prolonged illness contributes neuroaxonal damage. Elevated those later suggests role neuroinflammation, potentially linked cardiovascular metabolic comorbidities.

Language: Английский

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A useful map with some blind spots still: neurofilament light protein differentiating behavioural variant frontotemporal dementia from psychiatric disorders

American Journal of Geriatric Psychiatry, Journal Year: 2024, Volume and Issue: 32(8), P. 1002 - 1003

Published: April 28, 2024

Language: Английский

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