The microbiome as a modulator of neurological health across the maternal-offspring interface
Journal of Clinical Investigation,
Journal Year:
2025,
Volume and Issue:
135(4)
Published: Feb. 16, 2025
The
maternal
microbiome
is
emerging
as
an
important
factor
that
influences
the
neurological
health
of
mothers
and
their
children.
Recent
studies
highlight
how
microbial
communities
in
gut
can
shape
early-life
development
ways
inform
long-term
trajectories.
Research
on
neurodevelopmental
effects
microbiomes
expanding
our
understanding
microbiome-gut-brain
axis
to
include
signaling
across
maternal-offspring
unit
during
perinatal
period.
In
this
Review,
we
synthesize
existing
literature
modulates
brain
function
behavior
both
developing
offspring.
We
present
evidence
from
human
animal
showing
interacts
with
environmental
factors
impact
risk
for
abnormalities.
further
discuss
molecular
cellular
mechanisms
facilitate
crosstalk
neuromodulation.
Finally,
consider
advancing
these
complex
interactions
could
lead
microbiome-based
interventions
promoting
offspring
health.
Language: Английский
Infections during pregnancy: An ongoing threat
Seminars in Perinatology,
Journal Year:
2025,
Volume and Issue:
unknown, P. 152075 - 152075
Published: April 1, 2025
Language: Английский
The evidence of influenza A virus infection during pregnancy as a risk factor for neuropsychiatric disorder in offspring
Molecular Psychiatry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: May 15, 2025
Language: Английский
Developmental programming of tissue-resident macrophages
Frontiers in Immunology,
Journal Year:
2024,
Volume and Issue:
15
Published: Nov. 7, 2024
Macrophages
are
integral
components
of
the
innate
immune
system
that
colonize
organs
early
in
development
and
persist
into
adulthood
through
self-renewal.
Their
fate,
whether
they
replaced
by
monocytes
or
retain
their
embryonic
origin,
depends
on
tissue
type
integrity.
influenced
environment,
a
phenomenon
referred
to
as
developmental
programming.
This
influence
extends
beyond
local
microenvironment
includes
soluble
factors
can
reach
macrophage
niche.
These
include
metabolites,
antibodies,
growth
factors,
cytokines,
which
may
originate
from
maternal
diet,
lifestyle,
infections,
other
triggers
perturbations.
influences
alter
transcriptional,
epigenetic,
metabolic
profiles,
affecting
cell-cell
communication
In
addition
crucial
role
immunity,
macrophages
play
vital
roles
homeostasis.
Consequently,
programming
these
long-lived
cells
modulate
physiology
pathology
throughout
life.
this
review,
we
discuss
ontogeny
macrophages,
necessity
niche
for
identity
function,
how
perturbations
affect
subtissular
niches,
thereby
influencing
disease
onset
progression
adulthood.
Understanding
effects
inform
targeted
interventions
preventive
strategies
against
diseases.
Finally,
understanding
consequences
will
shed
light
health
impact
well-being
future
generations.
Language: Английский