bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: July 10, 2024

Abstract Corticotropin-releasing factor (CRF, encoded by Crh ) signaling is thought to play a critical role in the development of excessive alcohol drinking and emotional physical pain associated with withdrawal. Here, we investigated parasubthalamic nucleus (PSTN) as potential source CRF relevant control consumption, affect, nociception mice. We identified PSTN neurons neuronal subpopulation that exerts potent unique influence on behavior promoting not only but also saccharin drinking, while are otherwise known suppress consummatory behaviors. Furthermore, causally implicated escalation intake produced chronic intermittent ethanol (CIE) vapor inhalation, mouse model use disorder. In contrast our predictions, ability increase mediated 1 signaling. Moreover, pattern behavioral disinhibition reduced driven their activation does support negative reinforcement motivational basis for concomitant drinking. Finally, silencing expression slowed down mice exposed CIE accelerated recovery from withdrawal-induced mechanical hyperalgesia. Altogether, results suggest may represent an important node brain circuitry linking disorder sweet liking novelty seeking.

Language: Английский