Left-Right Brain-Wide Asymmetry of Neuroanatomy in the Mouse Brain DOI Creative Commons
Andrew Silberfeld, James M. Roe, Jacob Ellegood

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: June 26, 2024

Abstract Left-right asymmetry of the human brain is widespread through its anatomy and function. However, limited microscopic understanding it exists, particularly for anatomical where there are few well-established animal models. In humans, most regions show subtle, population-average regional asymmetries in thickness or surface area, alongside a macro-scale twisting called cerebral petalia which right hemisphere protrudes anteriorly past left. Here, we ask whether neuroanatomical can be observed mice, leveraging 6 mouse neuroimaging cohorts from 5 different research groups (∼3,500 animals). We found an anterior-posterior pattern volume with anterior larger on posterior This appears driven by similar trends area positional asymmetries, results together indicating small brain-wide pattern, to petalia. Furthermore, no apparent relationship known functional emphasizing complexity structure-function asymmetry. By establishing signature aim provide foundation future studies probe mechanistic underpinnings seen humans – feature extremely understanding. Significance Statement The shows significant left-right Understanding basis has implications autism schizophrenia, evolution, embryonic development, between structure function brain. One biggest challenges this aspect that models limited. Here using over 3,500 animals six independent cohorts. These findings mice interrogate roadmap exploring additional species.

Language: Английский

Left-Right Brain-Wide Asymmetry of Neuroanatomy in the Mouse Brain. DOI Creative Commons
Andrew Silberfeld, James M. Roe, Jacob Ellegood

et al.

NeuroImage, Journal Year: 2025, Volume and Issue: unknown, P. 121017 - 121017

Published: Jan. 1, 2025

Left-right asymmetry of the human brain is widespread through its anatomy and function. However, limited microscopic understanding it exists, particularly for anatomical where there are few well-established animal models. In humans, most regions show subtle, population-average regional asymmetries in thickness or surface area, alongside a macro-scale twisting called cerebral petalia which right hemisphere protrudes anteriorly past left. Here, we ask whether neuroanatomical can be observed mice, leveraging 6 mouse neuroimaging cohorts from 5 different research groups (∼3,500 animals). We found an anterior-posterior pattern volume with anterior larger on posterior This appears driven by similar trends area positional asymmetries, results together indicating small brain-wide pattern, to petalia. Furthermore, no apparent relationship known functional emphasizing complexity structure-function asymmetry. Our recapitulate extend previous patterns two published studies as well capture well-established, bilateral male-female differences positive control. By establishing signature aim provide foundation future probe mechanistic underpinnings seen humans - feature extremely understanding.

Language: Английский

Citations

1
Hemispheric Asymmetry of Intracortical Myelin Orientation in the Mouse Auditory Cortex DOI Creative Commons
Philip Ruthig, G.A. Müller, Mathias Fink

et al.

European Journal of Neuroscience, Journal Year: 2025, Volume and Issue: 61(2)

Published: Jan. 1, 2025

ABSTRACT Communication sound processing in mouse AC is lateralized. Both left and right are highly specialised differ auditory stimulus representation, functional connectivity field topography. Previous studies have highlighted intracortical circuits that explain hemispheric preference. However, the underlying microstructure remains poorly understood. In this study, we examine structural lateralization of on basis immunohistochemically stained tissue‐cleared adult brains ( n = 11). We found asymmetries myelination, most prominently layer 2/3, which featured more intercolumnar connections AC. Furthermore, a larger asymmetry also investigated sex differences. male mice, myelination direction tilted to anterior side. This pattern inverted female mice. spatial distribution neuronal cell bodies along laminar axis cortex was remarkably symmetric all samples. These results suggest basic developmentally defined structures such as cortical columns remain untouched by lateral specialisation, but plastic myelinated axons show diverse asymmetries. may contribute specialisation lateralized tasks vocal communication or spectral temporal complexity stimuli.

Language: Английский

Citations

1
The Balance in the Head: How Developmental Factors Explain Relationships Between Brain Asymmetries and Mental Diseases DOI Creative Commons
Martina Manns, Georg Juckel, Nadja Freund

et al.

Brain Sciences, Journal Year: 2025, Volume and Issue: 15(2), P. 169 - 169

Published: Feb. 9, 2025

Cerebral lateralisation is a core organising principle of the brain that characterised by complex pattern hemispheric specialisations and interhemispheric interactions. In various mental disorders, functional and/or structural asymmetries are changed compared to healthy controls, these alterations may contribute primary symptoms cognitive impairments specific disorder. Since multiple genetic epigenetic factors influence both pathogenesis illness development asymmetries, it likely neural developmental pathways overlap or even causally intertwined, although timing, magnitude, direction interactions vary depending on However, underlying steps neuronal mechanisms still unclear. this review article, we briefly summarise what know about structural, functional, relationships outline hypothetical connections, which could be investigated in appropriate animal models. Altered cerebral features disorder, as trigger neuropathogenesis embedded asymmetrical organisation developing brain. Therefore, occurrence severity processing cognition probably cannot understood independently lateralised intra- networks. Conversely, impaired cellular processes can also hinder favourable asymmetry lead deficits particular.

Language: Английский

Citations

1
Left-Right Brain-Wide Asymmetry of Neuroanatomy in the Mouse Brain DOI Creative Commons
Andrew Silberfeld, James M. Roe, Jacob Ellegood

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: June 26, 2024

Abstract Left-right asymmetry of the human brain is widespread through its anatomy and function. However, limited microscopic understanding it exists, particularly for anatomical where there are few well-established animal models. In humans, most regions show subtle, population-average regional asymmetries in thickness or surface area, alongside a macro-scale twisting called cerebral petalia which right hemisphere protrudes anteriorly past left. Here, we ask whether neuroanatomical can be observed mice, leveraging 6 mouse neuroimaging cohorts from 5 different research groups (∼3,500 animals). We found an anterior-posterior pattern volume with anterior larger on posterior This appears driven by similar trends area positional asymmetries, results together indicating small brain-wide pattern, to petalia. Furthermore, no apparent relationship known functional emphasizing complexity structure-function asymmetry. By establishing signature aim provide foundation future studies probe mechanistic underpinnings seen humans – feature extremely understanding. Significance Statement The shows significant left-right Understanding basis has implications autism schizophrenia, evolution, embryonic development, between structure function brain. One biggest challenges this aspect that models limited. Here using over 3,500 animals six independent cohorts. These findings mice interrogate roadmap exploring additional species.

Language: Английский

Citations

2