Influence of antipsychotic drugs on microglia-mediated neuroinflammation in schizophrenia: perspectives in an astrocyte–microglia co-culture model DOI Creative Commons
Timo Jendrik Faustmann,

Franco Corvace,

Pedro M. Faustmann

et al.

Frontiers in Psychiatry, Journal Year: 2025, Volume and Issue: 16

Published: March 18, 2025

Schizophrenia is a severe mental disorder with strong lifetime impact on patients' health and wellbeing. Usually, symptomatic treatment includes typical or atypical antipsychotics. Study findings show an involvement of low-grade inflammation (blood, brain parenchyma, cerebrospinal fluid) in schizophrenia. Moreover, experimental neuropathological evidence suggests that reactive microglia, which are the main resident immune cells central nervous system (CNS), have negative differentiation function oligodendrocytes, glial progenitor cells, astrocytes, results disruption neuronal networks dysregulated synaptic transmission, contributing to pathophysiology Here, role microglial related neuroinflammation schizophrenia was discussed be essential. This review aims summarize for influence antipsychotics inflammatory mechanisms Furthermore, we propose established astrocyte-microglia co-culture model testing regulatory examining effects glia-mediated neuroinflammation. could lead better understanding how can used address positive symptoms comorbidities like diseases status inflammation.

Language: Английский

Shrimp peptide QMDDQ improves scopolamine-induced memory impairments by activating the Notch1 signaling pathway DOI

Peng-Fei Yan,

Junchao Wang,

Xiyu Zhao

et al.

Food Bioscience, Journal Year: 2025, Volume and Issue: unknown, P. 106041 - 106041

Published: Feb. 1, 2025

Language: Английский

Citations

0
A single dose of haloperidol decanoate induces short-term hippocampal neuroinflammation: focus on the glial response DOI
Izaviany Schmitz, Larissa Daniele Bobermin, Amanda da Silva

et al.

Pharmacological Reports, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 21, 2025

Language: Английский

Citations

0
Research Progress on Glial Cells in Neurodegenerative Diseases DOI Creative Commons
Jiawei Zeng, Chao Jiang

Journal of Contemporary Medical Practice, Journal Year: 2025, Volume and Issue: 7(2), P. 18 - 23

Published: Feb. 28, 2025

This review discusses glial cells in neurodegenerative diseases as represents their role and scientific advances. Glial specifically offer support to neurons all fields of normal functioning while also participating processes such damage repair under pathological minutiae. The article the above with respect Alzheimer’s, Parkinson’s, multiple sclerosis, other ailments by combining latest research findings discuss potential therapeutic targets intervention avenues. It emphasizes that understanding cell functions engages can be critical they develop novel treatment approaches for debilitating conditions.

Language: Английский

Citations

0
Unraveling the potential of neuroinflammation and autophagy in schizophrenia DOI

Hongxia Tao,

Cheng‐Xiang Wang, Chuan Zou

et al.

European Journal of Pharmacology, Journal Year: 2025, Volume and Issue: 997, P. 177469 - 177469

Published: March 5, 2025

Language: Английский

Citations

0
Influence of antipsychotic drugs on microglia-mediated neuroinflammation in schizophrenia: perspectives in an astrocyte–microglia co-culture model DOI Creative Commons
Timo Jendrik Faustmann,

Franco Corvace,

Pedro M. Faustmann

et al.

Frontiers in Psychiatry, Journal Year: 2025, Volume and Issue: 16

Published: March 18, 2025

Schizophrenia is a severe mental disorder with strong lifetime impact on patients' health and wellbeing. Usually, symptomatic treatment includes typical or atypical antipsychotics. Study findings show an involvement of low-grade inflammation (blood, brain parenchyma, cerebrospinal fluid) in schizophrenia. Moreover, experimental neuropathological evidence suggests that reactive microglia, which are the main resident immune cells central nervous system (CNS), have negative differentiation function oligodendrocytes, glial progenitor cells, astrocytes, results disruption neuronal networks dysregulated synaptic transmission, contributing to pathophysiology Here, role microglial related neuroinflammation schizophrenia was discussed be essential. This review aims summarize for influence antipsychotics inflammatory mechanisms Furthermore, we propose established astrocyte-microglia co-culture model testing regulatory examining effects glia-mediated neuroinflammation. could lead better understanding how can used address positive symptoms comorbidities like diseases status inflammation.

Language: Английский

Citations

0