Contribution of the serotonergic system to developmental brain abnormalities in autism spectrum disorder DOI Creative Commons

Jarek Wegiel,

Kathryn K. Chadman,

Eric London

et al.

Autism Research, Journal Year: 2024, Volume and Issue: 17(7), P. 1300 - 1321

Published: March 18, 2024

This review highlights a key role of the serotonergic system in brain development and distortions normal early stages fetal life resulting cascades abnormalities, including defects neurogenesis, neuronal migration, growth, differentiation, arborization, as well defective circuit formation cortex, subcortical structures, brainstem, cerebellum autistic subjects. In autism, regulation growth are most frequent ubiquitous developmental changes associated with impaired neuron smaller size, distorted shape, loss spatial orientation, distortion cortex organization. Common autism include multiregional focal dysplastic contributing to local distortion, epileptogenic activity, epilepsy. There is discrepancy between more than 500 reports demonstrating contribution autism's behavioral anomalies, highlighted by lack studies subjects' brainstem raphe nuclei, center innervation, diagnostic features spectrum disorder (ASD). Discovery severe auditory deficits other anomalies leading hearing cascade alterations, social verbal communication individuals another argument intensify postmortem type topography of, severity nuclei their abnormal broad functional comorbid conditions ASD.

Language: Английский

Neural circuits regulating prosocial behaviors DOI Open Access
Jessica J. Walsh, Daniel J. Christoffel, Robert C. Malenka

et al.

Neuropsychopharmacology, Journal Year: 2022, Volume and Issue: 48(1), P. 79 - 89

Published: June 14, 2022

Language: Английский

Citations

47
Therapeutic mechanisms of psychedelics and entactogens DOI
Boris D. Heifets, David E. Olson

Neuropsychopharmacology, Journal Year: 2023, Volume and Issue: 49(1), P. 104 - 118

Published: July 24, 2023

Language: Английский

Citations

30
Context-specific functions of chromatin remodellers in development and disease DOI
Sai Gourisankar, A. Krokhotin,

Wendy Wenderski

et al.

Nature Reviews Genetics, Journal Year: 2023, Volume and Issue: 25(5), P. 340 - 361

Published: Nov. 24, 2023

Language: Английский

Citations

25
MDMA enhances empathy-like behaviors in mice via 5-HT release in the nucleus accumbens DOI Creative Commons
Benjamin Rein,

Kendall B. Raymond,

Cali Boustani

et al.

Science Advances, Journal Year: 2024, Volume and Issue: 10(17)

Published: April 24, 2024

MDMA (3,4-methylenedioxymethamphetamine) is a psychoactive drug with powerful prosocial effects. While sometimes termed an "empathogen," empirical studies have struggled to clearly demonstrate these effects or pinpoint underlying mechanisms. Here, we paired the social transfer of pain and analgesia-behavioral tests modeling empathy in mice-with region-specific neuropharmacology, optogenetics, transgenic manipulations explore MDMA's action as empathogen. We report that MDMA, given intraperitoneally infused directly into nucleus accumbens (NAc), robustly enhances analgesia. Optogenetic stimulation 5-HT release NAc recapitulates implicating signaling core mechanism. Last, systemic optogenetic inputs restores deficits empathy-like behaviors

Language: Английский

Citations

11
Physical activity promotes brain development through serotonin during early childhood DOI

Jia-Qi Jing,

Si-Jia Jia,

Chang-Jiang Yang

et al.

Neuroscience, Journal Year: 2024, Volume and Issue: 554, P. 34 - 42

Published: Aug. 1, 2024

Language: Английский

Citations

11
Diverse Physiological Roles of Kynurenine Pathway Metabolites: Updated Implications for Health and Disease DOI Creative Commons

Yuechang Wang,

Yonggang Zhang, Wei Wang

et al.

Metabolites, Journal Year: 2025, Volume and Issue: 15(3), P. 210 - 210

Published: March 20, 2025

Tryptophan is an essential amino acid critical for human health. It plays a pivotal role in numerous physiological and biochemical processes through its metabolism. The kynurenine (KYN) pathway serves as the principal metabolic route tryptophan, producing bioactive metabolites, including KYN, quinolinic acid, 3-hydroxykynurenine. Numerous studies are actively investigating relationship between tryptophan metabolism functions. These highlighting interactions among metabolites that may exert synergistic or antagonistic effects, such neuroprotective neurotoxic, pro-oxidative antioxidant activities. Minor disruptions homeostasis of these can result immune dysregulation, contributing to spectrum diseases. diseases include neurological disorders, mental illnesses, cardiovascular conditions, autoimmune diseases, chronic kidney disease. Therefore, understanding roles KYN elucidating contribution health regulation. present review emphasizes their mechanisms disease development, aiming establish theoretical basis leveraging dietary nutrients enhance

Language: Английский

Citations

1
Modulation of 5-HT release by dynorphin mediates social deficits during opioid withdrawal DOI Creative Commons
Matthew B. Pomrenze, Daniel F. Cardozo Pinto,

Peter A. Neumann

et al.

Neuron, Journal Year: 2022, Volume and Issue: 110(24), P. 4125 - 4143.e6

Published: Oct. 5, 2022

Language: Английский

Citations

39
Towards the convergent therapeutic potential of G protein‐coupled receptors in autism spectrum disorders DOI Creative Commons
Anil Annamneedi, Caroline Gora, Ana Dudas

et al.

British Journal of Pharmacology, Journal Year: 2023, Volume and Issue: unknown

Published: Aug. 14, 2023

Abstract Autism spectrum disorders (ASDs) are diagnosed in 1/100 children worldwide, based on two core symptoms: deficits social interaction and communication, stereotyped behaviours. G protein‐coupled receptors (GPCRs) the largest family of cell‐surface that transduce extracellular signals to convergent intracellular signalling downstream cellular responses commonly dysregulated ASD. Despite hundreds GPCRs being expressed brain, only 23 genetically associated with ASD according Simons Foundation Research Initiative (SFARI) gene database: oxytocin OTR; vasopressin V 1A 1B ; metabotropic glutamate mGlu 5 7 GABA B2 dopamine D 1 , 2 3 serotoninergic 5‐HT β ‐adrenoceptor; cholinergic M adenosine A 2A angiotensin AT cannabinoid CB chemokine CX CR1; orphan GPR37 GPR85; olfactory OR1C1, OR2M4, OR2T10 OR52M1. Here, we review therapeutic potential these GPCRs, as well for For each GPCR, discuss its genetic association, pharmacological manipulation animal models, pharmacopoeia symptoms rank them factors. Among highlight OTR more promising targets We dysregulation their is a pathological mechanism Their has begun multiple could mitigate

Language: Английский

Citations

15
Attenuation of Autism-like Behaviors by an Anthocyanin-Rich Extract from Portuguese Blueberries via Microbiota–Gut–Brain Axis Modulation in a Valproic Acid Mouse Model DOI Open Access
Diana Serra, Joana F. Henriques, Fábio J. Sousa

et al.

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(16), P. 9259 - 9259

Published: Aug. 17, 2022

Autism Spectrum Disorders (ASDs) are a group of neurodevelopmental pathologies whose current treatment is neither curative nor effective. Anthocyanins naturally occurring compounds abundant in blueberries and other red fruits which have been shown to be successful the several neurological diseases, at least vitro vivo disease models. The aim present work was study ability an anthocyanin-rich extract (ARE) obtained from Portuguese alleviate autism-like symptoms valproic acid (VPA) mouse model ASD get insights into underlying molecular mechanisms such benefits. Therefore, pregnant BALB/c females were treated subcutaneously with single dose VPA (500 mg/kg) or saline on gestational day 12.5. Male offspring mice orally ARE (30 mg/kg/day) vehicle for three weeks, further subjected behavioral tests biochemical analysis. Our data suggested that alleviated behaviors utero VPA-exposed and, same time, decreased both neuroinflammation gut inflammation, modulated microbiota composition, increased serotonin levels cerebral prefrontal cortex gut, reduced synaptic dysfunction verified autistic mice. Overall, our suggests anthocyanins extracted could constitute effective strategy ameliorate typical through modulation microbiota-gut-brain axis.

Language: Английский

Citations

21
Understanding copy number variations through their genes: a molecular view on 16p11.2 deletion and duplication syndromes DOI Creative Commons
Roberta Leone,

Cecilia Zuglian,

Riccardo Brambilla

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: June 14, 2024

Neurodevelopmental disorders (NDDs) include a broad spectrum of pathological conditions that affect >4% children worldwide, share common features and present variegated genetic origin. They clinically defined diseases, such as autism (ASD), attention-deficit/hyperactivity disorder (ADHD), motor Tics Tourette’s syndromes, but also much more heterogeneous like intellectual disability (ID) epilepsy. Schizophrenia (SCZ) has recently been proposed to belong NDDs. Relatively causes NDDs are copy number variations (CNVs), characterised by the gain or loss portion chromosome. In this review, we focus on deletions duplications at 16p11.2 chromosomal region, associated with NDDs, ID, ASD epilepsy SCZ. Some core phenotypes presented human carriers could be recapitulated in animal cellular models, which highlighted prominent neurophysiological signalling alterations underpinning CNVs-associated phenotypes. provide an overview genes within locus, including those partially known unknown function well non-coding RNAs. A particularly interesting interplay was observed between MVP MAPK3 modulating some deletion. Elucidating their role intracellular functional links will key step devise novel therapeutic strategies for CNVs-related syndromes.

Language: Английский

Citations

5