Neuropsychopharmacology,
Journal Year:
2023,
Volume and Issue:
49(1), P. 150 - 162
Published: July 24, 2023
Abstract
We
have
known
for
nearly
a
century
that
triggering
seizures
can
treat
serious
mental
illness,
but
what
we
do
not
know
is
why.
Electroconvulsive
Therapy
(ECT)
works
faster
and
better
than
conventional
pharmacological
interventions;
however,
those
benefits
come
with
burden
of
side
effects,
most
notably
memory
loss.
Disentangling
the
mechanisms
by
which
ECT
exerts
rapid
therapeutic
benefit
from
driving
adverse
effects
could
enable
development
next
generation
seizure
therapies
lack
downside
ECT.
The
latest
research
suggests
this
goal
may
be
attainable
because
modifications
technique
already
yielded
improvements
in
cognitive
outcomes
without
sacrificing
efficacy.
These
involve
changes
how
electricity
administered
(both
where
brain,
much),
turn
impacts
characteristics
resulting
seizure.
What
completely
understand
whether
it
applied
electricity,
or
seizure,
both,
are
responsible
improved
safety.
Answering
question
key
to
developing
these
ushering
novel
interventions
better,
faster,
safer
Abstract
Chronic
neuropathic
pain
is
a
debilitating
neuroplastic
disorder
that
notably
impacts
the
quality
of
life
millions
people
worldwide.
This
complex
condition,
encompassing
various
manifestations,
such
as
sciatica,
diabetic
neuropathy
and
postherpetic
neuralgia,
arises
from
nerve
damage
or
malfunctions
in
processing
pathways
involves
biological,
physiological
psychological
processes.
Maladaptive
neuroplasticity,
known
central
sensitization,
plays
critical
role
persistence
chronic
pain.
Current
treatments
for
include
pharmacological
interventions
(for
example,
antidepressants
anticonvulsants),
invasive
procedures
deep
brain
stimulation)
physical
therapies.
However,
these
approaches
often
have
limitations
potential
side
effects.
In
light
challenges,
interest
noninvasive
neuromodulation
techniques
alternatives
complementary
increasing.
These
methods
aim
to
induce
analgesia
while
reversing
maladaptive
plastic
changes,
offering
advantages
over
conventional
practices
methods.
Recent
technological
advancements
spurred
exploration
therapies,
repetitive
transcranial
magnetic
stimulation,
direct
current
stimulation
ultrasound
well
innovative
transformations
into
at
both
preclinical
clinical
levels.
Here
this
review
aims
critically
examine
mechanisms
neuroplasticity
evaluate
efficacy
relief.
By
focusing
on
optimizing
techniques,
we
can
better
assess
their
short-term
long-term
effects,
refine
treatment
variables
ultimately
improve
management.
Journal of Translational Medicine,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: Sept. 13, 2024
Multiple
Sclerosis
(MS)
is
an
autoimmune
disease
associated
with
physical
disability,
psychological
impairment,
and
cognitive
dysfunctions.
Consequently,
the
burden
substantial,
treatment
choices
are
limited.
In
this
randomized,
double-blind
study,
we
conducted
repeated
prefrontal
electrical
stimulation
in
40
patients
MS
to
evaluate
mental
health
variables
(quality
of
life,
sleep
difficulties,
distress)
dysfunctions
(psychomotor
speed,
working
memory,
attention/vigilance),
marking
it
as
third
largest
sample
size
tDCS
research
date.
Journal of Neural Engineering,
Journal Year:
2022,
Volume and Issue:
19(5), P. 056020 - 056020
Published: Sept. 8, 2022
Objective.Recently
developed
magnetoelectric
nanoparticles
(MENPs)
provide
a
potential
tool
to
enable
different
biomedical
applications.
They
could
be
used
overcome
the
intrinsic
constraints
posed
by
traditional
neurostimulation
techniques,
namely
invasiveness
of
electrodes-based
limited
spatial
resolution,
and
scarce
efficiency
magnetic
stimulation.Approach.By
using
computational
electromagnetic
we
modelled
behaviour
recently
designed
biocompatible
MENPs
injected,
in
shape
clusters,
specific
cortical
targets
highly
detailed
anatomical
head
model.
The
distributions
tissue
penetration
electric
fields
induced
clusters
each
will
compared
transcranial
stimulation
(TMS)
coils
for
non-invasive
brain
positioned
on
left
prefrontal
cortex
(PFC)
model.Main
results.MENPs
can
induce
focused
with
amplitude
close
neural
activation
threshold
all
tissues
interest
treatment
most
neuropsychiatric
disorders.
Conversely,
TMS
several
tens
V
m-1over
broad
volume
PFC,
but
they
are
unlikely
able
efficiently
stimulate
even
small
volumes
subcortical
deep
tissues.Significance.Our
numerical
results
suggest
that
use
may
potentially
led
future
pinpoint
neuropshychiatric
disorders,
which
an
impairment
activity
networks
has
been
assumed
play
crucial
role.
Frontiers in Neural Circuits,
Journal Year:
2024,
Volume and Issue:
18
Published: April 4, 2024
Cognitive
control
of
behavior
is
crucial
for
well-being,
as
allows
subject
to
adapt
changing
environments
in
a
goal-directed
way.
Changes
cognitive
observed
during
decline
elderly
and
pathological
mental
conditions.
Therefore,
the
recovery
may
provide
reliable
preventive
therapeutic
strategy.
However,
its
neural
basis
not
completely
understood.
supported
by
prefrontal
cortex,
structure
that
integrates
relevant
information
appropriate
organization
behavior.
At
neurophysiological
level,
it
suggested
local
large-scale
synchronization
oscillatory
activity
patterns
spiking
between
cortex
distributed
networks.
In
this
review,
we
focus
mainly
on
rodent
models
approaching
neuronal
origin
these
patterns,
behavioral
relevance
coordination
with
brain
systems.
We
also
examine
relationship
role
normal
Finally,
based
body
evidence,
propose
common
mechanism
underlie
impaired
Biomedicines,
Journal Year:
2023,
Volume and Issue:
11(6), P. 1513 - 1513
Published: May 23, 2023
We
review
the
research
progress
on
noninvasive
neural
regulatory
systems
through
system
design
and
theoretical
guidance.
provide
an
overview
of
development
history
neuromodulation
technology,
focusing
design.
also
discuss
typical
cases
that
use
modern
electrical
stimulation
main
limitations
associated
with
this
technology.
In
addition,
we
propose
a
closed-loop
solution
“time
domain”,
“space
“multi-electrode
combination”.
For
guidance,
paper
provides
“digital
brain”
process
used
for
electrical-stimulation-targeted
modeling
human”
programs
in
various
countries.
summarize
core
problems
existing
according
to
achievements
segmenting
tissue.
this,
tissue
parameters
multimodal
image
obtained
from
fresh
cadaver
were
considered
as
index.
The
digital
projection
brain
living
individual
was
implemented,
following
which
segmented
tissues
could
be
reconstructed
obtain
twin
model
personalized
structure
differences.
“closed-loop
system”
“personalized
not
only
enable
achieve
visualization
results
adaptive
regulation
but
have
differences
more
accurate
stimulation.
Faculty Reviews,
Journal Year:
2023,
Volume and Issue:
12
Published: June 7, 2023
Electroconvulsive
therapy
(ECT),
the
oldest
somatic
still
in
use
psychiatry
today,
remains
one
of
most
effective
therapeutic
interventions
for
a
wide
variety
psychiatric
disorders.
In
this
article,
we
review
some
recent
advances
ECT
that
are
currently
being
researched
and
implemented
clinical
practice.
We
explore
studies
point
to
potential
benefit
safety
COVID-19-related
neuropsychiatric
complications
special
populations
(such
as
elderly
pregnant
persons)
generally
at
higher
risk
having
adverse
effects
from
psychotropic
medications.
highlight
performed
head-to-head
comparison
ketamine,
which
has
shown
promise
treatment-resistant
depression
acute
suicidality.
Researchers
continue
different
ways
using
by
modifying
treatment
parameters
maintain
efficacy
decrease
side
effects.
Neurocognitive
remain
major
drawbacks
its
contribute
negative
stigma
highly
treatment.
regard,
describe
attempts
improve
dosing
parameters,
novel
electrode
placements,
addition
augmenting
agents
with
aim
decreasing
improving
efficacy.
This
identifies
last
few
years
research
while
also
highlighting
areas
where
further
is
needed.
Journal of Personalized Medicine,
Journal Year:
2022,
Volume and Issue:
12(5), P. 844 - 844
Published: May 22, 2022
The
registry
project
led
by
the
Japanese
Society
for
Clinical
Transcranial
Magnetic
Stimulation
(TMS)
Research
aims
to
establish
a
centralized
database
of
epidemiological,
clinical,
and
biological
data
on
TMS
therapy
refractory
psychiatric
disorders,
including
treatment-resistant
depression,
as
well
contribute
elucidation
therapeutic
mechanism
validation
its
efficacy
analyzing
evaluating
these
in
systematic
approach.
objective
this
is
collect
wide
range
complex
linked
patients
with
various
neuropsychiatric
disorders
who
received
throughout
Japan,
make
effective
use
promote
cross-sectional
longitudinal
exploratory
observational
studies.
utilizing
will
be
conducted
multicenter,
non-invasive,
retrospective,
prospective
research
study
design,
regardless
framework
insurance
medical
care,
private
practice,
or
clinical
research.
Through
establishment
registry,
which
data,
we
advance
treatment
mechanisms
identification
predictors
response
more
real-world
basis.
Furthermore,
future
vision,
aim
develop
novel
neuromodulation
devices,
algorithms
predicting
efficacy,
digital
therapeutics
based
knowledge
generated
from
database.
