Frontiers in Neural Circuits,
Journal Year:
2024,
Volume and Issue:
18
Published: April 4, 2024
Cognitive
control
of
behavior
is
crucial
for
well-being,
as
allows
subject
to
adapt
changing
environments
in
a
goal-directed
way.
Changes
cognitive
observed
during
decline
elderly
and
pathological
mental
conditions.
Therefore,
the
recovery
may
provide
reliable
preventive
therapeutic
strategy.
However,
its
neural
basis
not
completely
understood.
supported
by
prefrontal
cortex,
structure
that
integrates
relevant
information
appropriate
organization
behavior.
At
neurophysiological
level,
it
suggested
local
large-scale
synchronization
oscillatory
activity
patterns
spiking
between
cortex
distributed
networks.
In
this
review,
we
focus
mainly
on
rodent
models
approaching
neuronal
origin
these
patterns,
behavioral
relevance
coordination
with
brain
systems.
We
also
examine
relationship
role
normal
Finally,
based
body
evidence,
propose
common
mechanism
underlie
impaired
Scientific Reports,
Journal Year:
2025,
Volume and Issue:
15(1)
Published: April 16, 2025
Abstract
The
importance
of
gastric
cancer
(GC)
and
the
role
deep
learning
techniques
in
categorizing
GC
histopathology
images
have
recently
increased.
Identifying
drawbacks
traditional
models,
including
lack
interpretability,
inability
to
capture
complex
patterns,
adaptability,
sensitivity
noise.
A
multi-channel
attention
mechanism-based
framework
is
proposed
that
can
overcome
limitations
conventional
models
by
dynamically
focusing
on
relevant
features,
enhancing
extraction,
capturing
relationships
medical
data.
uses
three
different
mechanism
channels
convolutional
neural
networks
extract
multichannel
features
during
classification
process.
framework’s
strong
performance
confirmed
competitive
experiments
conducted
a
publicly
available
Gastric
Histopathology
Sub-size
Image
Database,
which
yielded
remarkable
accuracies
99.07%
98.48%
validation
testing
sets,
respectively.
Additionally,
HCRF
dataset,
achieved
high
accuracy
99.84%
99.65%
effectiveness
interchangeability
are
further
ablation
experiments,
highlighting
histopathological
image
tasks.
This
offers
an
advanced
pragmatic
artificial
intelligence
solution
addresses
challenges
posed
unique
characteristics
for
intricate
analysis.
approach
engineering
demonstrates
significant
potential
diagnostic
precision
achieving
treatment
outcomes.
bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2023,
Volume and Issue:
unknown
Published: March 10, 2023
Understanding
how
genetic
variation
exerts
its
effects
on
the
human
brain
in
health
and
disease
has
been
greatly
informed
by
functional
genomic
characterization.
Studies
over
last
decade
have
demonstrated
robust
evidence
of
convergent
transcriptional
epigenetic
profiles
post-mortem
cerebral
cortex
from
individuals
with
Autism
Spectrum
Disorder
(ASD).
Here,
we
perform
deep
single
nuclear
(sn)
RNAseq
to
elucidate
changes
cell
composition,
cellular
transcriptomes
putative
candidate
drivers
associated
ASD,
which
corroborate
using
snATAC-seq
spatial
profiling.
We
find
state
composition
representing
transitions
homeostatic
reactive
microglia
astrocytes,
a
pattern
extending
oligodendrocytes
blood
barrier
cells.
identify
profound
differential
expression
involving
thousands
genes
across
neuronal
glial
subtypes,
substantial
portion
can
be
accounted
for
specific
transcription
factor
networks
that
are
significantly
enriched
common
rare
risk
ASD.
These
data,
available
as
part
PsychENCODE
consortium,
provide
causal
anchors
resultant
molecular
phenotypes
understanding
ASD
brain.
Journal of Affective Disorders,
Journal Year:
2024,
Volume and Issue:
350, P. 887 - 894
Published: Jan. 23, 2024
Ablative
surgery
using
bilateral
anterior
capsulotomy
(BAC)
is
an
option
for
treatment
resistant
depression
(TRD)
and
obsessive-compulsive
disorder
(TROCD).
The
location
extent
of
the
lesion
within
limb
internal
capsule
(ALIC)
remains
uncertain.
Accumulating
evidence
has
suggested
that
should
be
located
ventrally
while
limiting
dorsal
extent.
Our
center
now
targeting
specific
fiber
tracts
lower
half
ALIC.
Presurgical
diffusion
tensor
Magnetic
Resonance
Imaging
(MRI)
was
used
to
identify
individual
fibre
ventral
aspect
ALIC
in
last
two
patients
who
underwent
BAC
at
our
center.
One
patient
had
TRD
other
both
TROCD
TRD.
Radiofrequency-induced
thermal
lesions
were
created
identified
targets
with
volumes
between
20
229
mm3
(average
95
mm3).
Both
responders
neither
experiencing
significant
side
effects
including
compromised
executive
functions.
generalizability
findings
limited
because
outcome
based
on
subjects.
This
work
suggests
can
individually
tailored
more
effective
safe
TROCD.
data
also
clinically
length
about
10mm.
BAC's
use
may
increase
growing
utilization
mastery
magnetic
resonance
guided
focused
ultrasound.
Frontiers in Neural Circuits,
Journal Year:
2024,
Volume and Issue:
18
Published: April 4, 2024
Cognitive
control
of
behavior
is
crucial
for
well-being,
as
allows
subject
to
adapt
changing
environments
in
a
goal-directed
way.
Changes
cognitive
observed
during
decline
elderly
and
pathological
mental
conditions.
Therefore,
the
recovery
may
provide
reliable
preventive
therapeutic
strategy.
However,
its
neural
basis
not
completely
understood.
supported
by
prefrontal
cortex,
structure
that
integrates
relevant
information
appropriate
organization
behavior.
At
neurophysiological
level,
it
suggested
local
large-scale
synchronization
oscillatory
activity
patterns
spiking
between
cortex
distributed
networks.
In
this
review,
we
focus
mainly
on
rodent
models
approaching
neuronal
origin
these
patterns,
behavioral
relevance
coordination
with
brain
systems.
We
also
examine
relationship
role
normal
Finally,
based
body
evidence,
propose
common
mechanism
underlie
impaired
