Contribution of leukocyte telomere length to major cardiovascular diseases onset: phenotypic and genetic insights from a large-scale genome-wide cross-trait analysis DOI
Siim Pauklin, Jun Qiao, Qian Wang

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 25, 2024

Abstract Telomere shortening, a marker of cellular aging and genomic instability, has been epidemiologically linked to an increased risk various cardiovascular diseases (CVDs). However, shared genetic determinants involved in these associations remain unclear. We composed atlas the between leukocyte telomere length (LTL) six major CVDs by investigating elements, encompassing SNPs, genes, biological pathways, protein targets with pleiotropic implications. Extensive overlaps beyond correlations were observed, but no causal relationships established. identified 248 independent loci, implicating 50 unique genes two or more trait pairs, especially SH2B3 gene, which was further validated proteome-wide Mendelian Randomization study. Functional analysis demonstrated link both DNA biosynthetic processes maintenance mechanisms. These findings suggest LTL CVDs, highlighting basis crucial for developing future interventions therapeutic targets.

Language: Английский

The role of senescence-related genes in major depressive disorder: insights from machine learning and single cell analysis DOI Creative Commons
Kun Lian,

Wei Yang,

Jing Ye

et al.

BMC Psychiatry, Journal Year: 2025, Volume and Issue: 25(1)

Published: March 3, 2025

Evidence indicates that patients with Major Depressive Disorder (MDD) exhibit a senescence phenotype or an increased susceptibility to premature senescence. However, the relationship between senescence-related genes (SRGs) and MDD remains underexplored. We analyzed 144 samples 72 healthy controls from GEO database compare SRGs expression. Using Random Forest (RF) Support Vector Machine-Recursive Feature Elimination (SVM-RFE), we identified five hub construct logistic regression model. Consensus cluster analysis, based on expression patterns, subclusters of patients. Weighted Gene Co-expression Network Analysis (WGCNA) gene modules strongly linked each cluster. Single-cell RNA sequencing was used analyze functions. The SRGs: ALOX15B, TNFSF13, MARCH 15, UBTD1, MAPK14 showed differential controls. Diagnostics models these demonstrated high accuracy. correlated positively neutrophils negatively T lymphocytes. pattern revealed two distinct subclusters. WGCNA significant within Additionally, individual endothelial cells scores were found interact astrocytes via Notch signaling pathway, suggesting specific role in pathogenesis. This comprehensive study elucidates MDD, highlighting importance pathway mediating effects.

Language: Английский

Citations

1
Subgrade cumulative deformation probabilistic prediction method based on machine learning DOI
Zhixing Deng,

Linrong Xu,

Yongwei Li

et al.

Soil Dynamics and Earthquake Engineering, Journal Year: 2025, Volume and Issue: 191, P. 109233 - 109233

Published: Jan. 22, 2025

Language: Английский

Citations

0
Health and aging trajectories: shared and competing risks and resiliencies for chronic diseases associated with aging. A NIH-wide workshop DOI Creative Commons
Ilsa I. Rovira, Arya Biragyn,

LaVerne L. Brown

et al.

Frontiers in Public Health, Journal Year: 2025, Volume and Issue: 13

Published: May 1, 2025

Language: Английский

Citations

0
Contribution of leukocyte telomere length to major cardiovascular diseases onset: phenotypic and genetic insights from a large-scale genome-wide cross-trait analysis DOI Open Access
Jun Qiao, Qian Wang, Yuhui Zhao

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: May 22, 2024

Abstract Telomere shortening, a marker of cellular aging and genomic instability, has been epidemiologically linked to an increased risk various cardiovascular diseases (CVDs). However, shared genetic determinants involved in these associations remain unclear. We composed atlas the between leukocyte telomere length (LTL) six major CVDs by investigating elements, encompassing SNPs, genes, biological pathways, protein targets with pleiotropic implications. Extensive overlaps beyond correlations were observed, but no causal relationships established. identified 248 independent loci, implicating 50 unique genes two or more trait pairs, especially SH2B3 gene, which was further validated proteome-wide Mendelian Randomization study. Functional analysis demonstrated link both DNA biosynthetic processes maintenance mechanisms. These findings suggest LTL CVDs, highlighting basis crucial for developing future interventions therapeutic targets.

Language: Английский

Citations

0
Contribution of Leukocyte Telomere Length to Major Cardiovascular Diseases Onset: Phenotypic and Genetic Insights from a Large-Scale Genome-Wide Cross-Trait Analysis DOI
Jun Qiao, Qian Wang, Yuhui Zhao

et al.

Published: Jan. 1, 2024

Language: Английский

Citations

0
Contribution of leukocyte telomere length to major cardiovascular diseases onset: insights from a large-scale genome-wide cross-trait analysis DOI
Siim Pauklin, Jun Qiao, Qian Wang

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: July 2, 2024

Abstract Telomere shortening, a marker of cellular aging and genomic instability, has been epidemiologically linked to an increased risk various cardiovascular diseases (CVDs). However, shared genetic determinants involved in these associations remain unclear. We composed atlas the between leukocyte telomere length (LTL) six major CVDs by investigating elements, encompassing SNPs, genes, biological pathways, protein targets with pleiotropic implications. Extensive overlaps beyond correlations were observed, but no causal relationships established. identified 248 independent loci, implicating 50 unique genes two or more trait pairs, especially SH2B3 gene, which was further validated proteome-wide Mendelian Randomization study. Functional analysis demonstrated link both DNA biosynthetic processes maintenance mechanisms. These findings suggest LTL CVDs, highlighting basis crucial for developing future interventions therapeutic targets.

Language: Английский

Citations

0
Contribution of leukocyte telomere length to major cardiovascular diseases onset: phenotypic and genetic insights from a large-scale genome-wide cross-trait analysis DOI
Siim Pauklin, Jun Qiao, Qian Wang

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 25, 2024

Abstract Telomere shortening, a marker of cellular aging and genomic instability, has been epidemiologically linked to an increased risk various cardiovascular diseases (CVDs). However, shared genetic determinants involved in these associations remain unclear. We composed atlas the between leukocyte telomere length (LTL) six major CVDs by investigating elements, encompassing SNPs, genes, biological pathways, protein targets with pleiotropic implications. Extensive overlaps beyond correlations were observed, but no causal relationships established. identified 248 independent loci, implicating 50 unique genes two or more trait pairs, especially SH2B3 gene, which was further validated proteome-wide Mendelian Randomization study. Functional analysis demonstrated link both DNA biosynthetic processes maintenance mechanisms. These findings suggest LTL CVDs, highlighting basis crucial for developing future interventions therapeutic targets.

Language: Английский

Citations

0