NeuroImage, Journal Year: 2024, Volume and Issue: 302, P. 120903 - 120903
Published: Oct. 24, 2024
Language: Английский
Translational Psychiatry, Journal Year: 2025, Volume and Issue: 15(1)
Published: April 11, 2025
Abstract Research has shown that many copy number variations (CNVs) increase the risk of neurodevelopmental disorders (e.g., autism, ADHD, schizophrenia). However, little is known about effects CNVs on brain development and function. Resting-state electroencephalography (EEG) a suitable method to study disturbances neuronal functioning in CNVs. We aimed determine whether there are resting-state EEG signatures characteristic children with pathogenic activity 109 CNV carriers (66 deletion carriers, 43 duplication carriers) aged 3 17 years was recorded for 4 minutes. To better account developmental variations, indices (power spectral density functional connectivity) were corrected normative model estimated from 256 Healthy Brain Network controls. Results showed decreased exponent aperiodic reduced alpha peak frequency carriers. Additionally, altered periodic components connectivity several bands. Deletion exhibited similar overall pattern deviations measures, although significance effect sizes relative control group varied across can be differentiated by their power gamma band low band, showing more disrupted alterations than The distinctive patterns found most prominent during adolescence. results suggest show electrophysiological compared neurotypical controls, regardless gene dosage affected genomic region. At same time, while duplications deletions share common alterations, each exhibits distinct alteration reflect dosage-specific effects.
Language: Английский
Citations
1
The Transmitter, Journal Year: 2024, Volume and Issue: unknown
Published: Jan. 1, 2024
Citations
0
NeuroImage, Journal Year: 2024, Volume and Issue: 302, P. 120903 - 120903
Published: Oct. 24, 2024
Language: Английский
Citations
0