Structural neural plasticity evoked by rapid-acting antidepressant interventions

Nature reviews. Neuroscience, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 18, 2024

Language: Английский

Synaptic Vesicle 2A (SV2A) Positron Emission Tomography (PET) Imaging as a Marker of Therapeutic Response in a Mouse Model of Depression

ACS Pharmacology & Translational Science, Journal Year: 2025, Volume and Issue: 8(2), P. 339 - 345

Published: Jan. 28, 2025

In this preclinical pilot study, we used [11C]UCB-J PET imaging to monitor the synaptic modulation in depression and after fluoxetine. was performed a validated mouse model of depression/anxiety (CORT model), effect 5-week treatment with fluoxetine tested. Depression/anxiety phenotype antidepressant action were confirmed using novelty-suppressed feeding test, previously CORT model. data showed significant decreases volume distribution (VT) most brain regions mice compared controls 5 weeks fluoxetine, trend toward restoration VT values control levels observed, although it reached significance only olfactory bulb. These preliminary support use study antidepressants. It provides excellent translational opportunities relationship between plasticity clinical efficacy

Language: Английский

Venous blood sampling for less invasive in vivo quantification of synaptic density with constant infusion of [18F]SynVesT-1 and PET

EJNMMI Research, Journal Year: 2025, Volume and Issue: 15(1)

Published: Feb. 3, 2025

Language: Английский