Imaging Biomarker Studies of Antipsychotic-Naïve First-Episode Schizophrenia in China: Progress and Future Directions DOI
Wenjing Zhang, Changjian Qiu, Su Lui

et al.

Schizophrenia Bulletin, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 22, 2025

Abstract Background and Hypothesis Identifying biomarkers at onset specifying the progression over early course of schizophrenia is critical for better understanding illness pathophysiology providing novel information relevant to prognosis treatment selection. Studies antipsychotic-naïve first-episode in China are making contributions this goal. Study Design A review was conducted how patients were identified studied, investigated biological measures, with a focus on neuroimaging, they extend regarding illness-related brain abnormality, effect characterization outcome prediction, subtype discovery patient stratification, comparison findings from western populations. Finally, biomarker studies should be future also discussed. Results Gray matter reduction has been most robust within temporo-frontal regions cerebellum, whereas altered function pronounced cerebello-cortical connections default mode network, each might related long-standing alterations acute physiological measurement. By studying untreated patients, progressive temporal frontal enlargements bilateral putamen found more likely effects illness, not just treatment. Some these changes potential predict clinical outcomes differentiate biologically subgroups. Conclusions Mostly data-driven approaches, helping identify candidate imaging that early-stage effects, subgroup differentiation. Future work needed translate application.

Language: Английский

Imaging Biomarker Studies of Antipsychotic-Naïve First-Episode Schizophrenia in China: Progress and Future Directions DOI
Wenjing Zhang, Changjian Qiu, Su Lui

et al.

Schizophrenia Bulletin, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 22, 2025

Abstract Background and Hypothesis Identifying biomarkers at onset specifying the progression over early course of schizophrenia is critical for better understanding illness pathophysiology providing novel information relevant to prognosis treatment selection. Studies antipsychotic-naïve first-episode in China are making contributions this goal. Study Design A review was conducted how patients were identified studied, investigated biological measures, with a focus on neuroimaging, they extend regarding illness-related brain abnormality, effect characterization outcome prediction, subtype discovery patient stratification, comparison findings from western populations. Finally, biomarker studies should be future also discussed. Results Gray matter reduction has been most robust within temporo-frontal regions cerebellum, whereas altered function pronounced cerebello-cortical connections default mode network, each might related long-standing alterations acute physiological measurement. By studying untreated patients, progressive temporal frontal enlargements bilateral putamen found more likely effects illness, not just treatment. Some these changes potential predict clinical outcomes differentiate biologically subgroups. Conclusions Mostly data-driven approaches, helping identify candidate imaging that early-stage effects, subgroup differentiation. Future work needed translate application.

Language: Английский

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