Analogies between HPV Behavior in Oral and Vaginal Cavity: Narrative Review on the Current Evidence in the Literature

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(5), P. 1429 - 1429

Published: March 1, 2024

Human genital papilloma virus infection is the most prevalent sexually transmitted in world. It estimated that more than 75% of active women contract this their lifetime. In 80% young women, there clearance within 18–24 months. developed countries, oral squamous cell carcinoma (OSCC) now frequent human (HPV)-related cancer, having surpassed cervical and it predicted by 2030 carcinomas will be HPV-related rather non-HPV-related form. However, are currently no screening programs for cavity infection. While natural history HPV cervix well known, oropharynx, not entirely clear. Furthermore, prevalence oropharynx unknown. Published studies have found wide-ranging estimates 2.6% to 50%. There also conflicting results regarding percentage presenting same type at two mucosal sites, ranging from 0 60%. Additionally, question arises as whether can develop infection, through contact or self-inoculation, should considered an independent event. still consensus on these topics, nor relationship between infections. Therefore, literature review aims evaluate evidence a connection HPV, while endorsing usefulness patients with high-risk means facilitating diagnosis early management lesions. Finally, emphasizes recommendation use vaccines primary prevention male female population effective successfully counteracting increasing incidence OSCC date.

Language: Английский

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From infection to immortality: The role of HPV and telomerase in head and neck cancer

Oral Oncology, Journal Year: 2025, Volume and Issue: 161, P. 107169 - 107169

Published: Jan. 5, 2025

Language: Английский

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High expression of H2AX/γ-H2AX is associated with distinct biological pathway alterations and shorter survival in oropharyngeal squamous cell carcinoma

Oral Oncology, Journal Year: 2025, Volume and Issue: 161, P. 107171 - 107171

Published: Jan. 5, 2025

Language: Английский

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The role of lipids and lipids lowering drugs in human papillomavirus (HPV) and HPV-associated cancers

Infectious Agents and Cancer, Journal Year: 2025, Volume and Issue: 20(1)

Published: Jan. 28, 2025

Both women and men are now confronted with the grave threat of cancers caused by human papillomavirus (HPV). It is estimated that 80% may encounter HPV over their lives. In preponderance cases involving anal, head neck, oral, oropharyngeal, penile, vaginal, vulvar, cervical malignancies, high-risk (HR-HPV) causative agent. 2019, believed to have been cause 620,000 new cancer in 70,000 worldwide. The bulk 530,000 (~ 270,000 fatalities) infection (86% cases, 88% deaths) happen poor nations each year. Lipid metabolism crucial development related HPV. One most noticeable metabolic abnormalities lipid reprogramming, which cells dysregulate obtain sufficient energy, building blocks for cell membranes, signaling molecules necessary invasion, metastasis, proliferation, survival. Moreover, proteins' stimulation production infected will probably a significant effect on oncogenesis. addition, lipids critical producing cellular epithelial-mesenchymal transition (EMT) process, therapy resistance HPV-related (HRCs). Therefore, essential HRC also be an important target approaches associated treatments during or development. This review study looked at role lipid-lowering drugs cancers.

Language: Английский

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Adjuvant Proton Radiation Following Transoral Robotic Surgery for HPV‐Positive Oropharyngeal Squamous Cell Carcinoma

Otolaryngology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 31, 2025

Advances in the treatment of human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC) include transoral robotic surgery (TORS) and proton beam therapy (PBT). This study aims to improve understanding toxicities associated with adjuvant PBT following TORS for OPSCC. A retrospective review. An academic tertiary care center Baltimore, Maryland. Patients undergoing followed by from 2017 2023 were reviewed. Forty-seven patients HPV-associated OPSCC underwent PBT. Forty-one (87.2%) male. The median age at first radiation fraction was 61.7 years. identified as white 6 (12.8%) African American. Most had T1 (23 [48.9%]) or T2 (22 [46.8%]), N1 (41 [87.2%]) disease. majority (98.3%) acute grade 1 2, only (2.1%) patient developing 3 toxicities. Three (6.4%) required a feeding tube nutrition during treatment. who tubes also postoperative nasogastric 16 days, compared days all other (Mann-Whitney U, P = .02). most common chronic included xerostomia, dysphagia, dysgeusia, lymphedema, which decreased over time. treated demonstrated favorable toxicity profile mostly 2 Feeding requirement low 6.4%. Many appeared decrease frequency time radiation, although further is required.

Language: Английский

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Rates of p16 and p53 expression in head and neck cutaneous squamous cell carcinoma vary according to human papillomavirus status

World Journal of Clinical Cases, Journal Year: 2025, Volume and Issue: 13(18)

Published: Feb. 26, 2025

The strong association between human papillomavirus (HPV) infection and oropharyngeal squamous cell carcinoma (SCC) is well-documented, with p16 expression serving as a reliable predictor of HPV involvement. HPV-related tumors are characterized by distinct mechanisms affecting p53 protein pathways. However, the prevalence combined predictive utility in head neck cutaneous SCC remain less explored, necessitating further research to understand their role this subset SCC. HPV, p16, statuses were determined using immunohistochemistry staining methods rather than more sensitive techniques such polymerase chain reaction or genotyping, limiting ability assess specific area types potentially associated prognosis. Further studies assessing multiple molecular markers patients will better predict diverse outcomes type treatment targeted those markers.

Language: Английский

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Oropharyngeal carcinomas induce circulating monocytes to express a TAM-like pro-tumor expression profile that suppresses T-cell proliferation

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: March 19, 2025

Introduction Tumor-associated macrophages (TAMs) recruited from circulating monocytes drive tumor-growth and establish an immunosuppressive tumor microenvironment (TME). Initial events in transition resting to TAMs are poorly understood. Here, we report that oropharyngeal cancer (OPC) patients control treated with OPC-conditioned media (CM) express a repertoire of pro-tumor mediators is characteristic TAMs. Methods Monocytes were stimulated OPC cell line CM, analyzed by single-cell RNAseq. Results select genes confirmed qPCR tumors vs. clinically normal tissue. spheroids containing T-cells established, TAM phenotype characterized flow analysis qPCR, T-cell proliferation assessed flow. induced multiple including CXCL1, CXCL5, CXCL8, SPP1, IL1B, GPNMB , FABP5 . Patient had higher baseline levels or achieved after stimulation than monocytes. A subset patient high CXCL9/-10/-11 expression resisted downregulation response stimulation, potential sign more favorable TME. biopsies compared tissue correlated outcome. Spheroid derived maintained the seen conditioned media. These suppress proliferation. Inhibition COX-2 IL1 signaling during differentiation into partially blocked suppression Conclusion Targeting early could be used develop new therapies for OPC.

Language: Английский

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Changing the paradigm: Elimination – Not only of cervical cancer

Gynecologic Oncology Reports, Journal Year: 2024, Volume and Issue: 54, P. 101445 - 101445

Published: July 3, 2024

The WHO's initiative to eliminate cervical cancer by 2030 does not address the increasing incidence of vulvar, anal, and oropharyngeal cancers linked high-risk HPV. Currently, prevention these three faces various obstacles, such as a lack specialized screening programs, well-defined management guidelines, widespread public awareness. Without any interventions, will likely rise in upcoming years, increasingly affecting younger individuals. We recommend expanding include cancers. This involves developing protocols similar those for cancer, implementing gender-neutral HPV vaccination establishing clear referral pathways centers, promoting awareness, providing education healthcare providers

Language: Английский

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Moderate SCRIB Expression Levels Correlate with Worse Prognosis in OPSCC Patients Regardless of HPV Status

Cells, Journal Year: 2024, Volume and Issue: 13(12), P. 1002 - 1002

Published: June 8, 2024

Head and neck cancers rank as the sixth most prevalent globally. In addition to traditional risk factors such smoking alcohol use, human papillomavirus (HPV) infections are becoming a significant causative agent of head cancers, particularly among Western populations. Although HPV offers survival benefit, search for better biomarkers is still ongoing. current study, our objective was investigate whether expression levels three PDZ-domain-containing proteins (SCRIB, NHERF2, DLG1), known E6 cellular substrates, influence HNSCC patients treated by primary surgery (n = 48). Samples were derived from oropharyngeal oral presence confirmed PCR p16 staining. Clinical follow-up information obtained hospital database Croatian Cancer registry up November 2023. Survival evaluated using Kaplan–Meier method Cox proportional hazard regression. The results corroborated through reanalysis comparable subset TCGA cancer 391). conclusion, targets studied, only SCRIB found be an independent predictor in regression analysis, along with tumor stage. Further studies more typical population setting needed since consumption prominent population, while strongest association between seen HPV-negative cases.

Language: Английский

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Onco-Ontogeny of Squamous Cell Cancer of the First Pharyngeal Arch Derivatives

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(18), P. 9979 - 9979

Published: Sept. 16, 2024

Head and neck squamous cell carcinoma (H&NSCC) is an anatomic, biological, genetic complex disease. It involves more than 1000 genes implied in its oncogenesis; for this review, we limit our search description to the onco-ontogeny of derivates from first pharyngeal arch during embryo development. They can be grouped as transcription factors signaling molecules (that act growth that bind receptors). Finally, propose term embryo-oncogenesis refer activation, reactivation, use involved embryo’s development oncogenesis or malignant tumor invasion metastasis events part onco-ontogenic inverse process.

Language: Английский

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