Warburg effect and lactylation in cancer: mechanisms for chemoresistance

Molecular Medicine, Journal Year: 2025, Volume and Issue: 31(1)

Published: April 22, 2025

Abstract In the clinical management of cancers, emergence chemoresistance represents a profound and imperative “pain point” that requires immediate attention. Understanding mechanisms is essential for developing effective therapeutic strategies. Importantly, existing studies have demonstrated glucose metabolic reprogramming, commonly referred to as Warburg effect or aerobic glycolysis, major contributor chemoresistance. Additionally, lactate, byproduct functions signaling molecule supports lysine lactylation modification proteins, which also plays critical role in However, it insufficient discuss glycolysis from single perspective. The intricate relationship between crucial promoting Thus, thorough elucidation underlying mediated by essential. This review provides comprehensive overview these further outlines exert synergistic effects, development creating positive feedback loop continues mediate this resistance. close link suggests application glycolysis-related drugs inhibitors cancer therapy may represent promising anticancer strategy. Furthermore, targeted lactylation, either alone combination with other treatments, offer new avenues overcoming

Language: Английский

Research progress on the regulatory role of lactate and lactylation in tumor microenvironment

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Journal Year: 2025, Volume and Issue: unknown, P. 189339 - 189339

Published: April 1, 2025

Language: Английский