Mitophagy and cGAS–STING crosstalk in neuroinflammation

Acta Pharmaceutica Sinica B, Journal Year: 2024, Volume and Issue: 14(8), P. 3327 - 3361

Published: May 13, 2024

Mitophagy, essential for mitochondrial health, selectively degrades damaged mitochondria. It is intricately linked to the cGAS–STING pathway, crucial innate immunity. This pathway responds DNA and associated with cellular stress. Our review explores molecular details regulatory mechanisms of mitophagy pathway. We critically evaluated literature demonstrating how dysfunctional leads neuroinflammatory conditions, primarily through accumulation mitochondria, activating activation prompts production proinflammatory cytokines, exacerbating neuroinflammation. emphasizes interaction between Effective might suppress offering protection against Conversely, impaired may activate potentially leading chronic Additionally, we explored this influences neurodegenerative disorders, suggesting a common mechanism in such diseases. In conclusion, there need additional targeted research unravel complexities mitophagy–cGAS–STING interactions their role neurodegeneration. highlights potential therapies targeting these pathways, which could lead new treatments conditions. synthesis enhances our understanding foundations neuroinflammation opens therapeutic avenues disease research.

Language: Английский

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Interferons and interferon-related pathways in heart disease

Frontiers in Cardiovascular Medicine, Journal Year: 2024, Volume and Issue: 11

Published: April 11, 2024

Interferons (IFNs) and IFN-related pathways play key roles in the defence against microbial infection. However, these processes may also be activated during pathogenesis of non-infectious diseases, where they contribute to organ injury, or function a compensatory manner. In this review, we explore IFNs heart disease. We consider cardiac effects type I IFN-stimulated genes (ISGs); emerging role cyclic GMP-AMP synthase (cGAS)-stimulator interferon (STING) pathway; seemingly paradoxical II IFN, IFN-γ; varied actions regulatory factor (IRF) family transcription factors. Recombinant small molecule inhibitors mediators IFN receptor signaling are already employed clinic for treatment some autoimmune infections, cancers. There has been renewed interest because their involvement SARS-CoV-2 infection, relatively recent emergence cGAS-STING as pattern recognition receptor-activated pathway. Whether advances will ultimately result improvements care those experiencing disease remains determined.

Language: Английский

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Beclin1 haploinsufficiency rescues low ambient temperature-induced cardiac remodeling and contractile dysfunction through inhibition of ferroptosis and mitochondrial injury

Metabolism, Journal Year: 2020, Volume and Issue: 113, P. 154397 - 154397

Published: Oct. 12, 2020

Language: Английский

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Double knockout of Akt2 and AMPK accentuates high fat diet-induced cardiac anomalies through a cGAS-STING-mediated mechanism

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Journal Year: 2020, Volume and Issue: 1866(10), P. 165855 - 165855

Published: June 5, 2020

Language: Английский

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Catecholamine-induced cardiotoxicity: A critical element in the pathophysiology of stroke-induced heart injury

Life Sciences, Journal Year: 2021, Volume and Issue: 287, P. 120106 - 120106

Published: Oct. 28, 2021

Language: Английский

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