International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(5), P. 4435 - 4435
Published: Feb. 23, 2023
This
study
aimed
to
identify
the
impact
of
mesenchymal
stem
cell
transplantation
on
safety
and
clinical
outcomes
patients
with
severe
COVID-19.
research
focused
how
lung
functional
status,
miRNA,
cytokine
levels
changed
following
in
COVID-19
pneumonia
their
correlation
fibrotic
changes
lung.
involved
15
conventional
anti-viral
treatment
(Control
group)
13
after
three
consecutive
doses
combined
MSC
(MCS
group).
ELISA
was
used
measure
levels,
real-time
qPCR
for
miRNA
expression,
computed
tomography
(CT)
imaging
grade
fibrosis.
Data
were
collected
day
patient
admission
(day
0)
7th,
14th,
28th
days
follow-up.
A
CT
assay
performed
weeks
2,
8,
24,
48
beginning
hospitalization.
The
relationship
between
biomarkers
peripheral
blood
function
parameters
investigated
using
analysis.
We
confirmed
that
triple
individuals
safe
did
not
cause
adverse
reactions.
total
score
from
Control
groups
differ
significantly
24
However,
week
48,
12
times
lower
group
(p
≤
0.05)
compared
group.
In
group,
this
parameter
gradually
decreased
2
observation,
whereas
a
significant
drop
observed
up
remained
unchanged
afterward.
our
study,
therapy
improved
lymphocyte
recovery.
percentage
banded
neutrophils
comparison
control
14.
Inflammatory
markers
such
as
ESR
CRP
more
rapidly
plasma
surfactant
D,
marker
alveocyte
type
II
damage,
four
contrast
whom
slight
elevations
observed.
first
showed
led
elevation
IP-10,
MIP-1α,
G-CSF,
IL-10.
inflammatory
IL-6,
MCP-1,
RAGE
groups.
had
no
relative
expression
miR-146a,
miR-27a,
miR-126,
miR-221,
miR-21,
miR-133,
miR-92a-3p,
miR-124,
miR-424.
vitro,
UC-MSC
exhibited
an
immunomodulatory
PBMC,
increasing
neutrophil
activation,
phagocytosis,
leukocyte
movement,
activating
early
T
markers,
decreasing
effector
senescent
maturation.
Frontiers in Bioscience-Landmark,
Journal Year:
2022,
Volume and Issue:
27(11), P. 316 - 316
Published: Nov. 30, 2022
Background:
The
recently
emerged
variants
of
the
severe
acute
respiratory
coronavirus
2
(SARS-CoV-2)
pose
a
threat
to
public
health.
Understanding
pathogenicity
these
is
salient
factor
in
development
effective
SARS-CoV-2
therapeutics.
This
study
aimed
compare
expression
patterns
genes
involved
immune
responses
K18-hACE2
mice
infected
with
wild-type,
Delta,
and
Omicron
variants.
Methods:
were
intranasally
either
wild-type
(B.1),
Delta
(B.1.617.2),
or
(B.1.1.529)
On
day
6
post-infection,
lung,
brain,
kidney
tissues
collected
from
each
variant-infected
group.
mRNA
levels
39
response
all
three
groups
compared
by
RT-qPCR.
Viral
titers
measured
using
median
tissue
culture
infectious
dose
(TCID50)
assay
expressed
as
Log10
TCID50/0.1
g.
statistical
significance
differences
gene
was
determined
one-way
analysis
variance
(ANOVA)
(alpha
=
0.05).
Results:
toll-like
receptors
(TLRs)
upregulated
lung
brain
wild-type-
Delta-infected
but
not
those
Omicron-infected
highest
cytokines,
including
interleukin
(IL)-1α,
IL-1β,
IL-17α,
interferon,
tumor
necrosis
factors,
observed
lungs
variant.
Additionally,
CCL4,
CCL11,
CXCL9,
CXCL10
(>3-fold)
wild-type-infected
mice,
markedly
higher
expressions
than
lungs.
Most
apoptotic
factors
mainly
(caspase
8,
caspase
9,
p53,
Bax,
Bak,
BCL-2,
Bcl-XL),
whereas
neither
nor
showed
more
3-fold
upregulation
factors.
Conclusions:
Collectively,
our
findings
revealed
that
variant
exhibited
pathogenicity,
followed
variant,
then
Cell Death Discovery,
Journal Year:
2024,
Volume and Issue:
10(1)
Published: March 19, 2024
Abstract
A
rising
number
of
patient
cases
point
to
a
probable
link
between
SARS-CoV-2
infection
and
Parkinson’s
disease
(PD),
yet
the
mechanisms
by
which
affects
brain
generates
neuropsychiatric
symptoms
in
COVID-19
patients
remain
unknown.
Ferroptosis,
distinct
iron-dependent
non-apoptotic
type
cell
death
characterized
lipid
peroxidation
glutathione
depletion,
key
factor
neurological
disorders.
Ferroptosis
may
have
pathogenic
role
COVID-19,
according
recent
findings,
however
its
potential
contributions
COVID-19-related
PD
not
been
investigated.
This
review
covers
paths
for
brain.
Among
these
putative
processes,
ferroptosis
contribute
etiology
COVID-19-associated
PD,
potentially
providing
therapeutic
methods.
bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2024,
Volume and Issue:
unknown
Published: June 17, 2024
SARS-CoV-2
is
a
highly
transmissible
virus
that
causes
COVID-19
disease.
Mechanisms
of
viral
pathogenesis
include
excessive
inflammation
and
viral-induced
cell
death,
resulting
in
tissue
damage.
We
identified
the
host
E3-ubiquitin
ligase
TRIM7
as
an
inhibitor
apoptosis
replication
via
ubiquitination
membrane
(M)
protein.
Scientific Reports,
Journal Year:
2024,
Volume and Issue:
14(1)
Published: July 26, 2024
Studies
have
demonstrated
that
prior
to
puberty,
girls
a
lower
incidence
and
severity
of
asthma
symptoms
compared
boys.
This
study
aimed
explore
the
role
progesterone
(P4),
sex
hormone,
in
reducing
inflammation
altering
immune
microenvironment
mouse
model
allergic
induced
by
OVA.
Female
BALB/c
mice
with
or
without
ovariectomy
remove
influence
hormones
were
used
for
investigations.
Serum,
bronchoalveolar
lavage
fluid
(BALF),
lung
tissue
samples
collected
analysis.
The
results
indicated
P4
treatment
was
effective
decreasing
mucus
secretion
lungs
OVA-induced
mice.
also
reduced
influx
inflammatory
cells
into
BALF
increased
levels
Th1
Th17
cytokines
while
Th2
Treg
both
CD45+
T
cells.
Furthermore,
inhibited
infiltration
lungs,
suppressed
NETosis,
number
pulmonary
CD4+
increasing
regulatory
neutrophil
elastase
inhibitor
GW311616A
airway
production
modified
Th1,
Th2,
Th17,
These
changes
led
an
alteration
immunological
milieu
cells,
accompanied
decreased
Treg,
CD44+
similar
effects
treatment.
Treatment
NETosis
suppressing
p38
pathway
activation,
leading
reactive
oxygen
species
production.
Moreover,
hindered
release
double-stranded
DNA
during
thereby
influencing
lungs.
findings
suggest
may
be
beneficial
associated
modulating
microenvironment.
In
conclusion,
this
research
indicates
potential
as
therapeutic
agent
ameliorating
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(5), P. 4435 - 4435
Published: Feb. 23, 2023
This
study
aimed
to
identify
the
impact
of
mesenchymal
stem
cell
transplantation
on
safety
and
clinical
outcomes
patients
with
severe
COVID-19.
research
focused
how
lung
functional
status,
miRNA,
cytokine
levels
changed
following
in
COVID-19
pneumonia
their
correlation
fibrotic
changes
lung.
involved
15
conventional
anti-viral
treatment
(Control
group)
13
after
three
consecutive
doses
combined
MSC
(MCS
group).
ELISA
was
used
measure
levels,
real-time
qPCR
for
miRNA
expression,
computed
tomography
(CT)
imaging
grade
fibrosis.
Data
were
collected
day
patient
admission
(day
0)
7th,
14th,
28th
days
follow-up.
A
CT
assay
performed
weeks
2,
8,
24,
48
beginning
hospitalization.
The
relationship
between
biomarkers
peripheral
blood
function
parameters
investigated
using
analysis.
We
confirmed
that
triple
individuals
safe
did
not
cause
adverse
reactions.
total
score
from
Control
groups
differ
significantly
24
However,
week
48,
12
times
lower
group
(p
≤
0.05)
compared
group.
In
group,
this
parameter
gradually
decreased
2
observation,
whereas
a
significant
drop
observed
up
remained
unchanged
afterward.
our
study,
therapy
improved
lymphocyte
recovery.
percentage
banded
neutrophils
comparison
control
14.
Inflammatory
markers
such
as
ESR
CRP
more
rapidly
plasma
surfactant
D,
marker
alveocyte
type
II
damage,
four
contrast
whom
slight
elevations
observed.
first
showed
led
elevation
IP-10,
MIP-1α,
G-CSF,
IL-10.
inflammatory
IL-6,
MCP-1,
RAGE
groups.
had
no
relative
expression
miR-146a,
miR-27a,
miR-126,
miR-221,
miR-21,
miR-133,
miR-92a-3p,
miR-124,
miR-424.
vitro,
UC-MSC
exhibited
an
immunomodulatory
PBMC,
increasing
neutrophil
activation,
phagocytosis,
leukocyte
movement,
activating
early
T
markers,
decreasing
effector
senescent
maturation.
