Therapeutic Advances in Chronic Disease,
Journal Year:
2025,
Volume and Issue:
16
Published: March 1, 2025
Cardiovascular
disease
(CVD)
still
poses
a
significant
risk
for
morbidity
and
mortality
in
patients
with
chronic
obstructive
pulmonary
(COPD).
For
long
time,
among
functional
parameters,
only
the
forced
expiratory
volume
1
s
(FEV1)
has
been
considered
as
predictive
of
cardiovascular
(CV)
especially
elderly
fact,
there
is
evidence
that
reductions
lung
function
indices
can
increase
ischaemic
heart
diseases
cerebrovascular
diseases,
independently
from
other
factors.
Now,
considerable
suggesting
hypoxemia,
systemic
inflammation,
oxidative
stress
hyperinflation
may
lead
to
an
early
sub-clinical
CV
involvement
affected
by
COPD.
Ageing
itself
impacts
specific
aspects
system,
including
reduced
beta-adrenergic
responsiveness,
increased
vagal
tone
myocardial
vascular
stiffness,
endothelial
dysfunction,
diminished
arterial
baroreflex
compromised
diastolic
function.
The
complex
involved
interactions
include
ageing
mechanisms
well
multiple
known
unknown
(e.g.
genetic)
CVDs
are
leading
causes
individuals
impaired
two
entities
commonly
coexist
poor
outcomes
experiencing
both
conditions.
However,
precise
responsible
this
association
remain
largely
unknown.
In
narrative
review,
we
summarize
current
knowledge
regarding
co-occurrence
COPD
CVD
focusing
on
shared
biological
pathways
these
Aggregate,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 6, 2024
Abstract
Diabetes
significantly
impairs
the
body's
wound‐healing
capabilities,
leading
to
chronic,
infection‐prone
wounds.
These
wounds
are
characterized
by
hyperglycemia,
inflammation,
hypoxia,
variable
pH
levels,
increased
matrix
metalloproteinase
activity,
oxidative
stress,
and
bacterial
colonization.
complex
conditions
complicate
effective
wound
management,
prompting
development
of
advanced
diabetic
care
strategies
that
exploit
specific
characteristics
such
as
acidic
pH,
high
glucose
stress
trigger
controlled
drug
release,
thereby
enhancing
therapeutic
effects
dressings.
Among
solutions,
hydrogels
emerge
promising
due
their
stimuli‐responsive
nature,
making
them
highly
for
managing
these
The
latest
advancements
in
mono/multi‐stimuli‐responsive
smart
showcase
superiority
potential
healthcare
materials,
highlighted
relevant
case
studies.
However,
traditional
dressings
fall
short
meeting
nuanced
needs
wounds,
adjustable
adhesion,
easy
removal,
real‐time
status
monitoring,
dynamic
release
adjustment
according
wound's
conditions.
Responsive
represent
a
significant
leap
forward
proficient
sensing
responding
environment,
offering
more
targeted
approach
treatment.
This
review
highlights
recent
dressing,
delivery,
emphasizing
role
improving
healing.
It
addresses
ongoing
challenges
future
directions,
aiming
guide
clinical
adoption.
Journal of Biological Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown, P. 108252 - 108252
Published: Feb. 1, 2025
Every
cell
in
the
body
is
exposed
to
a
certain
level
of
CO2
and
O2.
Hypercapnia
hypoxia
elicit
stress
signals
influence
cellular
metabolism
function.
Both
conditions
exert
profound
yet
distinct
effects
on
metabolic
pathways
mitochondrial
dynamics,
highlighting
need
for
cells
adapt
changes
gaseous
microenvironment.
The
interplay
between
hypercapnia
signalling
key
dictating
homeostasis
as
microenvironmental
O2
levels
are
inextricably
linked.
Hypercapnia,
characterized
by
elevated
pCO₂,
introduces
adaptations
within
aerobic
pathways,
affecting
TCA
cycle
flux,
lipid,
amino
acid
metabolism,
OXPHOS
ETC.
Hypoxia,
defined
reduced
oxygen
availability,
necessitates
shift
from
anaerobic
glycolysis
sustain
ATP
production,
process
orchestrated
stabilisation
HIF-1α.
Given
that
present
both
physiological
cancerous
microenvironments,
how
might
coexistence
function
niches
tumor
microenvironment?
FEBS Journal,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 11, 2025
Redox
homeostasis,
the
delicate
balance
between
oxidative
and
reductive
processes,
is
crucial
for
cellular
function
overall
organismal
health.
At
molecular
level,
cells
need
to
maintain
a
fine
levels
of
reactive
oxygen
species
(ROS)
reducing
equivalents
such
as
glutathione
nicotinamide
adenine
dinucleotide
phosphate.
The
perturbation
redox
homeostasis
due
excessive
ROS
production
leads
stress
that
can
damage
lipids,
proteins,
nucleic
acids.
Conversely,
an
overly
reduced
environment
overabundant
results
in
stress,
which
also
interferes
with
important
signaling
physiological
processes.
Disrupted
linked
various
pathological
conditions,
including
neurodegenerative
diseases,
inflammatory
cancer,
cardiovascular
diseases.
Cells
employ
diverse
mechanisms
manage
imbalance.
hypoxia
response
pathway,
mediated
by
hypoxia‐inducible
factors
responsible
sensing
defending
against
low
levels,
plays
vital
role
maintaining
homeostasis.
In
this
review,
we
highlight
complex
multifaceted
crosstalk
discuss
avenues
future
research.
Understanding
link
stresses
essential
comprehending
several
conditions
associated
Therapeutic Advances in Chronic Disease,
Journal Year:
2025,
Volume and Issue:
16
Published: March 1, 2025
Cardiovascular
disease
(CVD)
still
poses
a
significant
risk
for
morbidity
and
mortality
in
patients
with
chronic
obstructive
pulmonary
(COPD).
For
long
time,
among
functional
parameters,
only
the
forced
expiratory
volume
1
s
(FEV1)
has
been
considered
as
predictive
of
cardiovascular
(CV)
especially
elderly
fact,
there
is
evidence
that
reductions
lung
function
indices
can
increase
ischaemic
heart
diseases
cerebrovascular
diseases,
independently
from
other
factors.
Now,
considerable
suggesting
hypoxemia,
systemic
inflammation,
oxidative
stress
hyperinflation
may
lead
to
an
early
sub-clinical
CV
involvement
affected
by
COPD.
Ageing
itself
impacts
specific
aspects
system,
including
reduced
beta-adrenergic
responsiveness,
increased
vagal
tone
myocardial
vascular
stiffness,
endothelial
dysfunction,
diminished
arterial
baroreflex
compromised
diastolic
function.
The
complex
involved
interactions
include
ageing
mechanisms
well
multiple
known
unknown
(e.g.
genetic)
CVDs
are
leading
causes
individuals
impaired
two
entities
commonly
coexist
poor
outcomes
experiencing
both
conditions.
However,
precise
responsible
this
association
remain
largely
unknown.
In
narrative
review,
we
summarize
current
knowledge
regarding
co-occurrence
COPD
CVD
focusing
on
shared
biological
pathways
these
