Macrophage‑driven pathogenesis in acute lung injury/acute respiratory disease syndrome: Harnessing natural products for therapeutic interventions (Review) DOI Creative Commons

Jincun Li,

Wenyu Ma,

Zilei Tang

et al.

Molecular Medicine Reports, Journal Year: 2024, Volume and Issue: 31(1)

Published: Nov. 4, 2024

Acute lung injury (ALI) or acute respiratory distress syndrome (ARDS) is a common disease characterized by hypoxemia and distress. It associated with high morbidity mortality. Due to the complex pathogenesis of ALI, clinical management patients ALI/ARDS challenging, resulting in numerous post‑treatment sequelae compromising quality life patients. Macrophages, as class innate immune cells, play an important role ALI/ARDS. In recent years, functions phenotypes macrophages have been better understood due development flow cytometry, immunofluorescence, single‑cell sequencing spatial genomics. However, no macrophage‑targeted drugs for treatment currently exist practice. Natural products are drug development, it has shown that natural compounds from herbal medicine can alleviate caused various factors modulating macrophage abnormalities. present review, modulate abnormalities treat introduced, their mechanisms action, discovered previous five years (2019‑2024), presented. This will provide novel ideas directions further research, develop new

Language: Английский

Pathogenesis of influenza and SARS-CoV-2 co-infection at the extremes of age: decipher the ominous tales of immune vulnerability DOI Creative Commons

Kailin Mai,

Weiqi Pan,

Zhengshi Lin

et al.

Advanced Biotechnology, Journal Year: 2025, Volume and Issue: 3(1)

Published: Jan. 21, 2025

The co-circulation of influenza and SARS-CoV-2 has led to co-infection events, primarily affecting children older adults, who are at higher risk for severe disease. Although prevalence is relatively low, it associated with worse outcomes compared mono-infections. Previous studies have shown that the depend on multiple factors, including viral interference, virus-host interaction host response. Children elderly exhibit distinct patterns antiviral response, which involve airway epithelium, mucociliary clearance, innate adaptive immune cells, inflammatory mediators. This review explores pathogeneses co-infection, focusing responses in elderly. By comparing immature immunity senescence we aim provide insights clinical management cases.

Language: Английский

Citations

2
Dual-Locked Fluorescence Probe for Monitoring the Dynamic Transition of Pulmonary Macrophages DOI
Yuxuan Hu, Jing Liu,

Mengke Xu

et al.

Journal of the American Chemical Society, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 13, 2025

Pulmonary macrophages undergo dynamic changes in population, proportion, and polarization during respiratory diseases. Monitoring these is critical for understanding their roles pathology, improving the diagnosis, guiding drug development. However, current analytic methods based on tissue biopsy are invasive static, limiting ability to provide such information. Herein, we report a dual-locked macrophage-specific renal-clearable probe (DMRPNOCas) monitoring of pulmonary influenza A virus (IAV) infection. DMRPNOCas activates fluorescence presence two biomarkers (caspase-1 NO) only coexpressed by M1 macrophages. To optimize NO reactivity, scaffold screened from hemicyanine derivatives with an o-phenylenediamine group positioned differently indole ring. Notably, para-substituted demonstrates higher NO-activated compared its meta-substituted counterpart. This enhancement, as revealed quantum chemical calculations, attributed differential inhibition twisted intramolecular charge transfer induced reaction. specifically distinguishes other leukocytes including T cells, neutrophils, M2 macrophages, capability unmatched single-locked control probes reported probes. Consequently, enables vivo uncovering extensive recruitment monocyte-derived within 48 h IAV process accompanied significant reduction alveolar These findings new insights into macrophage-mediated inflammation underscore potential precise diagnosis pathological processes.

Language: Английский

Citations

2
Early innate cell interactions with Mycobacterium tuberculosis in protection and pathology of tuberculosis DOI Creative Commons

Poornima Sankar,

Bibhuti B. Mishra

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: Oct. 27, 2023

Tuberculosis (TB) remains a significant global health challenge, claiming the lives of up to 1.5 million individuals annually. TB is caused by human pathogen

Language: Английский

Citations

21
Modulation of alveolar macrophage and mitochondrial fitness by medicinal plant-derived nanovesicles to mitigate acute lung injury and viral pneumonia DOI Creative Commons

Lusha Ye,

Yanan Gao, Simon Wing Fai Mok

et al.

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: April 18, 2024

Acute lung injury (ALI) is generally caused by severe respiratory infection and characterized overexuberant inflammatory responses inefficient pathogens-containing, the two major processes wherein alveolar macrophages (AMs) play a central role. Dysfunctional mitochondria have been linked with distorted hence disorders, but few treatments are currently available to correct these defects. Plant-derive nanovesicles gained significant attention because of their therapeutic potential, targeting cells underlying mechanism remain elusive. We herein prepared from Artemisia annua, well-known medicinal plant multiple attributes involving anti-inflammatory, anti-infection, metabolism-regulating properties. By applying three mice models acute bacterial endotoxin, influenza A virus (IAV) SARS-CoV-2 pseudovirus respectively, we showed that Artemisia-derived (ADNVs) substantially alleviated immunopathology raised survival rate challenged mice. Macrophage depletion adoptive transfer studies confirmed requirement AMs for ADNVs effects. identified gamma-aminobutyric acid (GABA) enclosed in vesicles molecular effector mediating regulatory roles ADNVs. Specifically, GABA acts on through receptors, promoting mitochondrial gene programming bioenergy generation, reducing oxidative stress signals, thereby enhancing adaptability inflammation resolution. Collectively, this study identifies promising nanotherapeutics alleviating pathology, elucidates whereby canonical neurotransmitter modifies resume tissue homeostasis, which may broader implications treating critical pulmonary diseases such as COVID-19.

Language: Английский

Citations

8
Immunotherapy strategies and prospects for acute lung injury: Focus on immune cells and cytokines DOI Creative Commons

Wenfang Zhu,

Yiwen Zhang, Ying-Hong Wang

et al.

Frontiers in Pharmacology, Journal Year: 2022, Volume and Issue: 13

Published: Dec. 22, 2022

Acute lung injury/acute respiratory distress syndrome (ALI/ARDS) is a disastrous condition, which can be caused by wide range of diseases, such as pneumonia, sepsis, traumas, and the most recent, COVID-19. Even though we have gained an improved understanding acute pathogenesis treatment mechanism, there still no effective for syndrome, partly responsible unacceptable mortality rate. In injury, inflammatory storm main pathological feature. More more evidences show that immune cells cytokines secreted play irreplaceable role in injury. Therefore, here mainly reviewed various injury from perspective immunotherapy, elaborated crosstalk cytokines, aiming to provide novel ideas targets

Language: Английский

Citations

25
Role of GM-CSF in lung balance and disease DOI Creative Commons
Yingzi Chen, Fan Li,

Mengqing Hua

et al.

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: April 4, 2023

Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a hematopoietic growth originally identified as stimulus that induces the differentiation of bone marrow progenitor cells into granulocytes and macrophages. GM-CSF now considered to be multi-origin pleiotropic cytokine. receptor signals activate JAK2 induce nuclear through JAK-STAT, MAPK, PI3K, other pathways. In addition promoting metabolism pulmonary surfactant maturation alveolar macrophages, plays key role in interstitial lung disease, allergic alcoholic bacterial, fungal, viral infections. This article reviews latest knowledge on relationship between balance indicates there much more than its name suggests.

Language: Английский

Citations

14
Diverse roles of lung macrophages in the immune response to influenza A virus DOI Creative Commons
Haoning Li, Aoxue Wang, Yuying Zhang

et al.

Frontiers in Microbiology, Journal Year: 2023, Volume and Issue: 14

Published: Sept. 13, 2023

Influenza viruses are one of the major causes human respiratory infections and newly emerging re-emerging strains influenza virus cause seasonal epidemics occasional pandemics, resulting in a huge threat to global public health systems. As early immune cells can rapidly recognize respond respiratory, lung macrophages play an important role controlling severity disease by limiting viral replication, modulating local inflammatory response, initiating subsequent adaptive responses. However, reproduction is both strain- macrophage type-dependent, ineffective replication some mouse has been observed. This review discusses function infection order better understand pathogenesis virus.

Language: Английский

Citations

12
Immune responses in COVID-19 patients: Insights into cytokine storms and adaptive immunity kinetics DOI Creative Commons
J Zhang

Heliyon, Journal Year: 2024, Volume and Issue: 10(14), P. e34577 - e34577

Published: July 1, 2024

SARS-CoV-2 infection can trigger cytokine storm in some patients, which characterized by an excessive production of cytokines and chemical mediators. This hyperactive immune response may cause significant tissue damage multiple organ failure (MOF). The severity COVID-19 correlates with the intensity storm, involving elements such as IFN, NF-κB, IL-6, HMGB1, etc. It is imperative to rapidly engage adaptive immunity effectively control disease progression. CD4

Language: Английский

Citations

4
Impaired inflammatory resolution with severe SARS-CoV-2 infection in leptin knock out obese hamster DOI Creative Commons
Ren-Di Jiang, Yang Luo,

Hao-Feng Lin

et al.

iScience, Journal Year: 2025, Volume and Issue: unknown, P. 111837 - 111837

Published: Jan. 1, 2025

Comorbidities, such as obesity, increase the risk of severe COVID-19. However, mechanisms underlying illnesses in individuals with obesity are poorly understood. Here, we used gene-edited leptin knock out (Leptin -/-) obese hamsters to establish a infection model. This model exhibits robust viral replication, lung lesions, pronounced clinical symptoms, and fatal infection, mirroring COVID-19 patients obesity. Using single-cell transcriptomics on tissues pre- post-infection, found that monocyte-derived alveolar macrophages (MD-AM) play key role hyper-inflammation, including two unique MD-AM cell fate branches specific Leptin -/- hamsters. Notably, reduced Trem2-dependent efferocytosis pathways indicated weakened inflammation resolution, consistent scRNA-seq data from In summary, our study highlights obesity-associated SARS-CoV-2 infections establishes reliable preclinical animal for developing obesity-specific therapeutics critical

Language: Английский

Citations

0
Alveolar macrophage endosomal-lysosomal system: potential therapeutic targets for COVID-19 DOI Creative Commons
Yungang Lan, Gaili Wang, Zhenzhen Wang

et al.

Animals and zoonoses., Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Citations

0