Interplay of p62-mTORC1 and EGFR signaling promotes cisplatin resistance in oral cancer DOI Creative Commons
Hsiu‐Chuan Chang, Cheng‐Chieh Yang, Lai‐Keng Loi

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(6), P. e28406 - e28406

Published: March 1, 2024

Cisplatin resistance poses a major challenge in the treatment of oral squamous cell carcinoma (OSCC). Deeper investigations into mechanisms underlying this drug is great importance. Here, we used cellular assays and clinical immunohistochemistry to examine molecular pathways involved both innate acquired cisplatin resistance. We demonstrated that p62-mTORC1 signaling complex plays pivotal role, driven by EGFR network, specifically through PI3K-Akt axis transcription factor C/EBP-β. Elevated p-mTOR expression was associated with cancer relapse poor prognosis among patients. Additionally, illustrated mTOR inhibitors enhance cytotoxic effect cisplatin, employing stem characteristics. Our work unveils fundamental for resistance, thereby presenting therapeutic implications OSCC.

Language: Английский

Oral squamous cell carcinomas: state of the field and emerging directions DOI Creative Commons

Yunhan Tan,

Zhihan Wang,

Mengtong Xu

et al.

International Journal of Oral Science, Journal Year: 2023, Volume and Issue: 15(1)

Published: Sept. 22, 2023

Oral squamous cell carcinoma (OSCC) develops on the mucosal epithelium of oral cavity. It accounts for approximately 90% malignancies and impairs appearance, pronunciation, swallowing, flavor perception. In 2020, 377,713 OSCC cases were reported globally. According to Global Cancer Observatory (GCO), incidence will rise by 40% 2040, accompanied a growth in mortality. Persistent exposure various risk factors, including tobacco, alcohol, betel quid (BQ), human papillomavirus (HPV), lead development potentially malignant disorders (OPMDs), which are lesions with an increased developing into OSCC. Complex multifactorial, oncogenesis process involves genetic alteration, epigenetic modification, dysregulated tumor microenvironment. Although therapeutic interventions, such as chemotherapy, radiation, immunotherapy, nanomedicine, have been proposed prevent or treat OPMDs, understanding mechanism facilitate identification prognostic thereby improving efficacy treatment patients. This review summarizes mechanisms involved Moreover, current interventions methods OPMDs discussed comprehension provide several prospective outlooks fields.

Language: Английский

Citations

274
Patient-derived head and neck cancer organoids allow treatment stratification and serve as a tool for biomarker validation and identification DOI Creative Commons
Rosemary Millen, W. W. B. de Kort,

Mandy Koomen

et al.

Med, Journal Year: 2023, Volume and Issue: 4(5), P. 290 - 310.e12

Published: May 1, 2023

BackgroundOrganoids are in vitro three-dimensional structures that can be grown from patient tissue. Head and neck cancer (HNC) is a collective term used for multiple tumor types including squamous cell carcinomas salivary gland adenocarcinomas.MethodsOrganoids were established HNC tissue characterized using immunohistochemistry DNA sequencing. Organoids exposed to chemo- radiotherapy panel of targeted agents. Organoid response was correlated with clinical response. CRISPR-Cas9-based gene editing organoids applied biomarker validation.FindingsA biobank consisting 110 models, 65 generated. retained alterations found HNC. Comparison organoid (primary [n = 6] adjuvant 15]) indicated potential guiding treatment options the setting. In organoids, radio-sensitizing cisplatin carboplatin could validated. However, cetuximab conveyed radioprotection most models. HNC-targeted treatments tested on 31 indicating possible novel stratification future. Activating PIK3CA mutations did not predict alpelisib organoids. Protein arginine methyltransferase 5 (PRMT5) inhibitors identified as option cyclin-dependent kinase inhibitor 2A (CDKN2A) null HNC.ConclusionsOrganoids hold diagnostic tool personalized medicine (RT) showed trend mimics response, predictive patient-derived Moreover, discovery validation.FundingThis work funded by Oncode PoC 2018-P0003

Language: Английский

Citations

51
Enhancing head and neck tumor management with artificial intelligence: Integration and perspectives DOI
Nian‐Nian Zhong, Hanqi Wang, Xinyue Huang

et al.

Seminars in Cancer Biology, Journal Year: 2023, Volume and Issue: 95, P. 52 - 74

Published: July 18, 2023

Language: Английский

Citations

45
Therapeutic advances of targeting receptor tyrosine kinases in cancer DOI Creative Commons
Ciprian Tomuleasa, Adrian Bogdan Țigu, Raluca Munteanu

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: Aug. 14, 2024

Abstract Receptor tyrosine kinases (RTKs), a category of transmembrane receptors, have gained significant clinical attention in oncology due to their central role cancer pathogenesis. Genetic alterations, including mutations, amplifications, and overexpression certain RTKs, are critical creating environments conducive tumor development. Following discovery, extensive research has revealed how RTK dysregulation contributes oncogenesis, with many subtypes showing dependency on aberrant signaling for proliferation, survival progression. These findings paved the way targeted therapies that aim inhibit crucial biological pathways cancer. As result, RTKs emerged as primary targets anticancer therapeutic Over past two decades, this led synthesis validation numerous small molecule kinase inhibitors (TKIs), now effectively utilized treating various types. In manuscript we provide comprehensive understanding context We explored alterations specific receptors across different malignancies, special dedicated examination current inhibitors, highlighting potential therapies. By integrating latest evidence, seek elucidate pivotal biology efficacy inhibition promising treatment outcomes.

Language: Английский

Citations

29
Role of E2F transcription factor in oral cancer: Recent insight and advancements DOI Creative Commons

Amal Kassab,

Ishita Gupta,

Ala‐Eddin Al Moustafa

et al.

Seminars in Cancer Biology, Journal Year: 2023, Volume and Issue: 92, P. 28 - 41

Published: March 15, 2023

The family of mammalian E2F transcription factors (E2Fs) comprise 8 members (E2F1-E2F8) classified as activators (E2F1-E2F3) and repressors (E2F4-E2F8) primarily regulating the expression several genes related to cell proliferation, apoptosis differentiation, mainly in a cycle-dependent manner. activity is frequently controlled via retinoblastoma protein (pRb), cyclins, p53 ubiquitin-proteasome pathway. Additionally, genetic or epigenetic changes result deregulation altering S phase entry apoptosis, an important hallmark for onset development cancer. Although studies reveal E2Fs be involved human malignancies, mechanisms underlying role oral cancer lies nascent needs further investigations. This review focuses on etiological activity, which turn transcriptionally control their target genes, thus contributing metastasis, drug/therapy resistance. Further, we will discuss therapeutic strategies E2Fs, may prevent tumor growth, drug

Language: Английский

Citations

35
Joint association of physical activity and dietary quality with survival among US cancer survivors: a population-based cohort study DOI Creative Commons
Xiaoyuan Wei, Yu Min, Zhongzheng Xiang

et al.

International Journal of Surgery, Journal Year: 2024, Volume and Issue: 110(9), P. 5585 - 5594

Published: June 14, 2024

Background: Limited studies have explored the joint effect of physical activity (PA) and dietary quality (DQ) on mortality outcomes cancer population. The authors aim to investigate separate prognostic PA DQ survival US survivors. Methods: Data survivors ( n =3007, representing 22 million survivors) were from National Health Nutrition Examination Survey (NHANES) between 2007 2018. was assessed using self-reported Global Physical Activity Questionnaire (GPAQ) evaluated through Eating Index-2015 (HEI-2015). Kaplan–Meier (KM) curves Cox proportional hazard model used evaluate associations effects with among Results: In analyses, sufficiently active (≥600 MET-min/week) qualified (≥60) presented reduced risks all-cause (HR 0.45, 95% CI: 0.35–0.59) as compared each lifestyle intervention separately. Meanwhile, either insufficiently or (>0 associated lower for 0.60, 0.40–0.90) noncancer 0.43, 0.32–0.59). Conclusions: Our study highlights combination strongly risk findings might help refine recommendations this

Language: Английский

Citations

16
Comprehensive Insights into Oral Squamous Cell Carcinoma: Diagnosis, Pathogenesis, and Therapeutic Advances DOI
Dharshini Jagadeesan,

Kathiresan V. Sathasivam,

Neeraj Kumar Fuloria

et al.

Pathology - Research and Practice, Journal Year: 2024, Volume and Issue: 261, P. 155489 - 155489

Published: July 27, 2024

Language: Английский

Citations

13
The Role of Oncogenic Viruses in Head and Neck Cancers: Epidemiology, Pathogenesis, and Advancements in Detection Methods DOI Creative Commons
Pinelopi Samara, Michail Athanasopoulos, Stylianos Mastronikolis

et al.

Microorganisms, Journal Year: 2024, Volume and Issue: 12(7), P. 1482 - 1482

Published: July 19, 2024

Head and neck cancers (HNCs) constitute a wide range of malignancies originating from the epithelial lining upper aerodigestive tract, including oral cavity, pharynx, larynx, nasal paranasal sinuses, salivary glands. Although lymphomas affecting this region are not conventionally classified as HNCs, they may occur in lymph nodes or mucosa-associated lymphoid tissues within head neck. Oncogenic viruses play crucial role HNC onset. Human papillomavirus (HPV) is extensively studied for its association with oropharyngeal cancers; nevertheless, other oncogenic also contribute to development. This review provides an overview epidemiology, pathogenesis, advancements detection methods associated recognizing HPV's well-established while exploring additional viral connections. Notably, Epstein-Barr virus linked nasopharyngeal carcinoma lymphomas. herpesvirus 8 implicated Kaposi's sarcoma, Merkel cell polyomavirus subsets HNCs. Additionally, hepatitis examined their potential Understanding contributions area critical refining therapeutic approaches. underlines interaction between region, highlighting necessity ongoing research elucidate mechanisms enhance clinical outcomes.

Language: Английский

Citations

9
Artificial Intelligence in Head and Neck Cancer: Innovations, Applications, and Future Directions DOI Creative Commons
Tuan D. Pham, Muy‐Teck Teh,

Domniki Chatzopoulou

et al.

Current Oncology, Journal Year: 2024, Volume and Issue: 31(9), P. 5255 - 5290

Published: Sept. 6, 2024

Artificial intelligence (AI) is revolutionizing head and neck cancer (HNC) care by providing innovative tools that enhance diagnostic accuracy personalize treatment strategies. This review highlights the advancements in AI technologies, including deep learning natural language processing, their applications HNC. The integration of with imaging techniques, genomics, electronic health records explored, emphasizing its role early detection, biomarker discovery, planning. Despite noticeable progress, challenges such as data quality, algorithmic bias, need for interdisciplinary collaboration remain. Emerging innovations like explainable AI, AI-powered robotics, real-time monitoring systems are poised to further advance field. Addressing these fostering among experts, clinicians, researchers crucial developing equitable effective applications. future HNC holds significant promise, offering potential breakthroughs diagnostics, personalized therapies, improved patient outcomes.

Language: Английский

Citations

9
The characterization of tumor immune microenvironment after neoadjuvant immunotherapy in head and neck squamous cell cancer using multiplex immunohistochemistry DOI Creative Commons

Zhaohong An,

Xiwei Zhang,

Zhaoyang Wang

et al.

Oral Oncology, Journal Year: 2025, Volume and Issue: 161, P. 107151 - 107151

Published: Jan. 1, 2025

Language: Английский

Citations

1