Published: Jan. 1, 2025
Language: Английский
Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)
Published: Sept. 20, 2024
Language: Английский
Citations
40
Nature Reviews Cardiology, Journal Year: 2024, Volume and Issue: 21(8), P. 556 - 573
Published: March 18, 2024
Language: Английский
Citations
23
Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 94, P. 102182 - 102182
Published: Jan. 4, 2024
Language: Английский
Citations
15
Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 14
Published: Jan. 5, 2024
Diabetic cardiomyopathy (DCM), one of the common complications diabetes, presents as a specific with anomalies in structure and function heart. With increasing prevalence DCM has high morbidity mortality worldwide. Recent studies have found that pyroptosis, programmed cell death accompanied by an inflammatory response, exacerbates growth genesis DCM. These provide theoretical basis for exploring potential treatment Therefore, this review aims to summarise possible mechanisms which pyroptosis promotes development well relevant targeting DCM, focusing on molecular NLRP3 inflammasome-mediated different cellular pathways associated effects occurring cells drugs inflammasome/pyroptosis This might fresh perspective foundation therapeutic agents
Language: Английский
Citations
9
Cardiovascular Diabetology, Journal Year: 2024, Volume and Issue: 23(1)
Published: June 29, 2024
Abstract In recent years, the incidence of diabetes has been increasing rapidly, posing a serious threat to human health. Diabetic cardiomyopathy (DCM) is characterized by cardiomyocyte hypertrophy, myocardial fibrosis, apoptosis, ventricular remodeling, and cardiac dysfunction in individuals with diabetes, ultimately leading heart failure mortality. However, underlying mechanisms contributing DCM remain incompletely understood. With advancements molecular biology technology, accumulating evidence shown that numerous non-coding RNAs (ncRNAs) crucial roles development progression DCM. This review aims summarize studies on involvement three types ncRNAs (micro RNA, long ncRNA circular RNA) pathophysiology DCM, goal providing innovative strategies for prevention treatment
Language: Английский
Citations
9
Redox Biology, Journal Year: 2024, Volume and Issue: 76, P. 103321 - 103321
Published: Aug. 19, 2024
Cell death constitutes a critical component of the pathophysiology cardiovascular diseases. A growing array non-apoptotic forms regulated cell (RCD)-such as necroptosis, ferroptosis, pyroptosis, and cuproptosis-has been identified is intimately linked to various conditions. These RCD are governed by genetically programmed mechanisms within cell, with epigenetic modifications being common crucial regulatory method. Such include DNA methylation, RNA histone acetylation, non-coding RNAs. This review recaps roles modifications, RNAs in diseases, well which regulate key proteins involved death. Furthermore, we systematically catalog existing pharmacological agents targeting novel their action article aims underscore pivotal role precisely regulating specific pathways thus offering potential new therapeutic avenues that may prove more effective safer than traditional treatments.
Language: Английский
Citations
9
Cardiovascular Drugs and Therapy, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 9, 2025
Language: Английский
Citations
1
International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 268, P. 130853 - 130853
Published: April 1, 2024
Language: Английский
Citations
7
Cardiovascular Diabetology, Journal Year: 2024, Volume and Issue: 23(1)
Published: April 15, 2024
Abstract The long-term high-fat diet (HFD) can cause myocardial lipotoxicity, which is characterized pathologically by hypertrophy, fibrosis, and remodeling clinically cardiac dysfunction heart failure in patients with obesity diabetes. Circular RNAs (circRNAs), a novel class of noncoding RNA ring formation through covalent bonds, play critical role various cardiovascular diseases. However, few studies have been conducted to investigate the mechanism circRNA lipotoxicity. Here, we found that circ_005077, formed exon 2–4 Crmp1, was significantly upregulated myocardium an HFD-fed rat. Furthermore, identified circ_005077 as ferroptosis-related regulator plays palmitic acid (PA) HFD-induced lipotoxicity vitro vivo. Mechanically, interacted Cyclophilin A (CyPA) inhibited its degradation via ubiquitination proteasome system (UBS), thus promoting interaction between CyPA p47phox enhance activity nicotinamide adenine dinucleotide phosphate (NADPH) oxidase responsible for ROS generation, subsequently inducing ferroptosis. Therefore, our results provide new insights into mechanisms potentially leading identification therapeutic target treatment future.
Language: Английский
Citations
7
British Journal of Pharmacology, Journal Year: 2024, Volume and Issue: unknown
Published: June 3, 2024
Cardiac remodelling involves structural, cellular and molecular alterations in the heart after injury, resulting progressive loss of function ultimately leading to failure. Circular RNAs (circRNAs) are a recently rediscovered class non-coding that play regulatory roles pathogenesis cardiovascular diseases, including Thus, more comprehensive understanding role circRNAs processes governing cardiac may set ground for development circRNA-based diagnostic therapeutic strategies. In this review, current knowledge about circRNA origin, conservation, characteristics is summarized. Bioinformatics wet-lab methods used research discussed. The mechanisms such as cell death, cardiomyocyte hypertrophy, inflammation, fibrosis metabolism highlighted. Finally, key challenges opportunities discussed, orientations future work address pharmacological potential failure proposed.
Language: Английский
Citations
6