Scientific Reports,
Journal Year:
2024,
Volume and Issue:
14(1)
Published: Jan. 4, 2024
Abstract
This
study
was
conducted
to
assess
the
effect
of
Evodiae
Fructus
70%
ethanol
extract
(EFE)
on
pathology
atopic
dermatitis
using
in
vitro
and
vivo
models.
The
major
compounds
EFE
were
identified
by
ultra-performance
liquid
chromatography
with
tandem
mass
spectrometry
as
rutaecarpine,
evodiamine,
evodol,
dehydroevodiamine,
limonin,
synephrine,
evocarpine,
dihydroevocarpine,
hydroxyevodiamine.
significantly
decreased
chemokine
levels
tumor
necrosis
factor-α/interferon-γ-stimulated
HaCaT
cells.
In
house
dust
mite-treated
NC/Nga
mice,
topical
application
score,
epidermal
hyperplasia
thickening,
mast
cell
infiltration,
plasma
histamine
corticosterone.
Thymic
stromal
lymphopoietin,
CD4
+
T
cells,
interleukin-4,
intercellular
adhesion
molecule-1
expression
lesioned
skin
reduced
treated
mice.
mechanism
elucidated
transcriptome
analysis,
followed
experimental
validation
Western
blotting
down-regulated
activation
Janus
kinase
(JAK)-signal
transducers
activators
transcription
(STAT)
mitogen-activated
protein
kinases
(MAPK)
signaling
pathways
improves
dermatitis-like
symptoms
suppressing
inflammatory
mediators,
cytokines,
chemokines
regulating
JAK-STAT
MAPK
pathways,
suggesting
its
use
a
potential
agent
for
treatment
dermatitis.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(15), P. 8327 - 8327
Published: July 30, 2024
Rheumatoid
arthritis
(RA)
is
a
highly
prevalent
autoimmune
disorder.
The
pathogenesis
of
the
disease
complex
and
involves
various
cellular
populations,
including
fibroblast-like
synoviocytes,
macrophages,
T
cells,
among
others.
Identification
signalling
pathways
molecules
that
actively
contribute
to
development
crucial
understanding
mechanisms
involved
in
chronic
inflammatory
environment
present
affected
joints.
Recent
studies
have
demonstrated
Janus
kinase/signal
transducer
activator
transcription
(JAK/STAT)
pathway
regulates
behaviour
immune
cells
contributes
progression
RA.
Several
JAK
inhibitors,
such
as
tofacitinib,
baricitinib,
upadacitinib,
filgocitinib,
been
developed,
their
efficacy
safety
patients
with
RA
comprehensively
investigated
number
clinical
trials.
Consequently,
inhibitors
approved
registered
treatment
for
In
this
review,
we
discuss
involvement
JAK/STAT
summarise
potential
beneficial
effects
implicated
disease.
Moreover,
most
important
phase
3
trials
evaluated
use
these
agents
patients.
Cancer Communications,
Journal Year:
2024,
Volume and Issue:
44(10), P. 1130 - 1167
Published: Aug. 1, 2024
The
intratumoral
microbiome
(TM)
refers
to
the
microorganisms
in
tumor
tissues,
including
bacteria,
fungi,
viruses,
and
so
on,
is
distinct
from
gut
circulating
microbiota.
TM
strongly
associated
with
tumorigenesis,
progression,
metastasis,
response
therapy.
This
paper
highlights
current
status
of
TM.
Tract
sources,
adjacent
normal
tissue,
circulatory
system,
concomitant
co-metastasis
are
main
origin
advanced
techniques
analysis
comprehensively
summarized.
Besides,
involved
progression
through
several
mechanisms,
DNA
damage,
activation
oncogenic
signaling
pathways
(phosphoinositide
3-kinase
[PI3K],
signal
transducer
activator
transcription
[STAT],
WNT/β-catenin,
extracellular
regulated
protein
kinases
[ERK]),
influence
cytokines
induce
inflammatory
responses,
interaction
microenvironment
(anti-tumor
immunity,
pro-tumor
microbial-derived
metabolites).
Moreover,
promising
directions
therapy
include
immunotherapy,
chemotherapy,
radiotherapy,
application
probiotics/prebiotics/synbiotics,
fecal
transplantation,
engineered
microbiota,
phage
therapy,
oncolytic
virus
inherent
challenges
clinical
also
review
provides
a
comprehensive
landscape
for
analyzing
TM,
especially
TM-related
mechanisms
TM-based
treatment
cancer.
Frontiers in Pharmacology,
Journal Year:
2024,
Volume and Issue:
14
Published: Jan. 3, 2024
Disturbances
in
immunoregulation
may
lead
to
both
cancer
and
autoimmune
diseases.
Many
therapeutic
drugs
for
diseases
also
display
anti-tumor
efficacy.
The
Janus
kinase/signal
transducer
activator
of
transcription
signaling
pathways
are
involved
the
secretion
more
than
50
distinct
cytokines,
which
have
critical
roles
inducing
tumorigenesis.
Thus,
kinases
become
classical
immunotherapeutic
targets
immune
disease.
More
70
kinase
inhibitors
been
approved
as
immunomodulatory
clinical
use,
12
used
treatment
This
systematic
review
aims
elucidate
role
clinically
that
were
primarily
designed
their
potential
translation
treatments.
Scientific Reports,
Journal Year:
2024,
Volume and Issue:
14(1)
Published: Jan. 4, 2024
Abstract
This
study
was
conducted
to
assess
the
effect
of
Evodiae
Fructus
70%
ethanol
extract
(EFE)
on
pathology
atopic
dermatitis
using
in
vitro
and
vivo
models.
The
major
compounds
EFE
were
identified
by
ultra-performance
liquid
chromatography
with
tandem
mass
spectrometry
as
rutaecarpine,
evodiamine,
evodol,
dehydroevodiamine,
limonin,
synephrine,
evocarpine,
dihydroevocarpine,
hydroxyevodiamine.
significantly
decreased
chemokine
levels
tumor
necrosis
factor-α/interferon-γ-stimulated
HaCaT
cells.
In
house
dust
mite-treated
NC/Nga
mice,
topical
application
score,
epidermal
hyperplasia
thickening,
mast
cell
infiltration,
plasma
histamine
corticosterone.
Thymic
stromal
lymphopoietin,
CD4
+
T
cells,
interleukin-4,
intercellular
adhesion
molecule-1
expression
lesioned
skin
reduced
treated
mice.
mechanism
elucidated
transcriptome
analysis,
followed
experimental
validation
Western
blotting
down-regulated
activation
Janus
kinase
(JAK)-signal
transducers
activators
transcription
(STAT)
mitogen-activated
protein
kinases
(MAPK)
signaling
pathways
improves
dermatitis-like
symptoms
suppressing
inflammatory
mediators,
cytokines,
chemokines
regulating
JAK-STAT
MAPK
pathways,
suggesting
its
use
a
potential
agent
for
treatment
dermatitis.
