Colloids and Surfaces B Biointerfaces, Journal Year: 2024, Volume and Issue: 246, P. 114385 - 114385
Published: Nov. 17, 2024
Language: Английский
Cancer Letters, Journal Year: 2024, Volume and Issue: 587, P. 216736 - 216736
Published: Feb. 17, 2024
Language: Английский
Citations
6
Cell Proliferation, Journal Year: 2024, Volume and Issue: 57(10)
Published: May 3, 2024
Abstract The Hippo signalling pathway is a conserved kinase cascade that orchestrates diverse cellular processes, such as proliferation, apoptosis, lineage commitment and stemness. With the onset of society ages, research on skeletal aging‐mechanics‐bone homeostasis has exploded. In recent years, aging mechanical force in system have gained groundbreaking progress. Under regulation mechanics aging, crucial role development bone. We synthesize current knowledge pathway, particularly its downstream effectors yes‐associated protein (YAP) transcriptional co‐activator with PDZ‐binding motif (TAZ), bone homeostasis. discuss specification function different cell types by pathway. interactions other pathways, Wnt, transforming growth factor beta nuclear kappa‐B, are also mentioned because their importance for modulating Furthermore, YAP/TAZ been extensively studied mechanotransducers. Due to space limitations, we focus reviewing how forces influence fate, communications through dysregulated
Language: Английский
Citations
5
Theranostics, Journal Year: 2024, Volume and Issue: 14(10), P. 3793 - 3809
Published: Jan. 1, 2024
: CD8
Language: Английский
Citations
4
Molecular Biomedicine, Journal Year: 2025, Volume and Issue: 6(1)
Published: March 5, 2025
Inflammation is a multifaceted defense mechanism of the immune system against infection. Chronic inflammation intricately linked to all stages tumorigenesis and therefore associated with an elevated risk developing serious cancers. Epigenetic mechanisms have capacity trigger as well facilitate tumor development transformation within inflammatory context. They achieve this by dynamically modulating expression both pro-inflammatory anti-inflammatory cytokines, which in turn sustains chronic inflammation. The aberrant epigenetic landscape reconfigures transcriptional programs oncogenic genes. This reconfiguration pivotal dictating biological functions cells cells. Aberrant histone H3 lysine 27 site (H3K27) methylation has been shown be involved behaviors such development, progression, response. establishment maintenance repressive mark dependent on involvement responsible modifying enzymes enhancer zeste homologue 2 (EZH2), jumonji domain containing 3 (JMJD3) ubiquitously transcribed tetratricopeptide repeat gene X (UTX) multiple cofactors. In addition, specific pharmacological agents modulate H3K27 levels, thereby carcinogenesis. review comprehensively summarises current characteristics clinical significance regulation context response progression.
Language: Английский
Citations
0
Chemical Biology & Drug Design, Journal Year: 2025, Volume and Issue: 105(3)
Published: March 1, 2025
ABSTRACT Protocatechuic acid (PCA) is a type of polyphenol with diverse biological activities, including antioxidant and anti‐inflammatory properties. This study aimed to explore the function PCA in acute respiratory distress syndrome (ARDS) delve into its functional mechanism. Lipopolysaccharides were applied stimulate human pulmonary microvascular endothelial cells (HPMECs) or C57BL/6 mice generate ARDS models vitro vivo. treatment (300 μM for 20 30 mg/kg mice) reduced proinflammatory cytokine production oxidative stress HPMECs mouse models, it cell apoptosis while alleviating alveolar septum thickening. Chromobox 4 (CBX4) was identified as target protein PCA, found activate transcription unconventional prefoldin RPB5 interactor 1 (URI1) by recruiting histone acetyltransferase general control nondepressible 5 (GCN5) promoter region. CBX4 URI1 levels LPS but restored PCA. Knockdown either negated ameliorating effects on LPS‐induced inflammation diminished promoting roles mitochondrial biogenesis mitophagy. suggests that holds promise CBX4/URI1‐mediated
Language: Английский
Citations
0
Clinical Epigenetics, Journal Year: 2025, Volume and Issue: 17(1)
Published: March 13, 2025
Signal transduction plays a pivotal role in modulating myriad of critical processes, including the tumour microenvironment (TME), cell cycle arrest, proliferation and apoptosis cells, as well their migration, invasion, epithelial–mesenchymal transition (EMT). Epigenetic mechanisms are instrumental genesis progression tumours. The Chromobox (CBX) family proteins, which serve significant epigenetic regulators, exhibit tumour-specific expression patterns biological functionalities. These proteins influenced by multitude factors could modulate activation diverse signalling pathways within cells through alterations modifications, thereby acting either oncogenic agents or suppressors. This review aims to succinctly delineate composition, structure, function, CBXs with an emphasis on synthesizing deliberating CBXs-mediated intracellular intricate governing tumourigenesis progression. Moreover, plethora contemporary studies have substantiated that might represent promising target for diagnosis therapeutic intervention patients. We also compiled scrutinized current research landscape concerning inhibitors targeting CBXs, aspiring aid researchers gaining deeper comprehension roles malignant evolution tumours, furnish novel perspectives innovation targeted therapeutics.
Language: Английский
Citations
0
Pharmacological Research, Journal Year: 2025, Volume and Issue: unknown, P. 107705 - 107705
Published: March 1, 2025
Language: Английский
Citations
0
Experimental Eye Research, Journal Year: 2025, Volume and Issue: unknown, P. 110353 - 110353
Published: March 1, 2025
Language: Английский
Citations
0
Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 177, P. 116962 - 116962
Published: June 26, 2024
Metabolic disorders are considered the hallmarks of cancer and metabolic reprogramming is emerging as a new strategy for treatment. Exogenous endogenous stressors can induce cellular senescence; interactions between senescence systemic metabolism dynamic. Cellular disrupts homeostasis in various tissues, which further promotes senescence, creating vicious cycle facilitating tumor occurrence, recurrence, altered outcomes anticancer treatments. Therefore, regulation related secretory phenotypes breakthrough therapy; moreover, proteins involved associated pathways prospective therapeutic targets. Although studies on association tumors have emerged recent years, elucidation this complex correlation required comprehensive knowledge. In paper, we review research progress cell aging metabolism, focusing strategies targeting to modulate relevant context anti-tumor therapy. Finally, discuss significance improving specificity safety anti-senescence drugs, potential challenge
Language: Английский
Citations
2
Cancer & Metabolism, Journal Year: 2024, Volume and Issue: 12(1)
Published: Oct. 25, 2024
Chondrosarcoma (CHS) is resistant to conventional chemotherapy and radiotherapy currently lacks effective treatment options when in advanced stages. Accordingly, this research investigated the mechanism of RNF2/CBX7 CHS drive development molecularly targeted drugs for CHS. RNF2 CBX7 levels were detected cells tissues. expression was modulated through cell transfection examine their effects on proliferation, apoptosis, migration, angiogenesis. The correlation between determined, ubiquitination level tested. Protein synthesis blocked RNF2-knockdown/overexpressing with CHX assess effect stability. JJ012 transfected LV-sh-RNF2 subcutaneously injected into nu/nu nude mice ascertain action growth metastasis highly expressed knockdown curbed angiogenesis while promoting apoptosis. upregulated protein reduced ubiquitination, whilst had no mRNA expression. partially nullified repressing angiogenesis, overexpression abolished promotional overexpression. prominently restricted tumor weight declined lung metastatic nodules Ki-67-positive mice. fosters progression by elevating degradation via pathway.
Language: Английский
Citations
2