Single-Cell Transcriptome Reveals the Heterogeneity of T Cells in Mice with Systemic Lupus Erythematosus and Neuronal Inflammation DOI Creative Commons
Zhijie Shi, Haihong Qin, Hao Wu

et al.

Journal of Inflammation Research, Journal Year: 2024, Volume and Issue: Volume 17, P. 11375 - 11402

Published: Dec. 1, 2024

Systemic lupus erythematosus is a heterogeneous autoimmune disease. A burst of reactions in various systems can lead to severe clinical conditions closely associated with mortality. T cells serve as mediators that drive the occurrence and maintenance inflammatory processes.

Language: Английский

Protein neddylation and its role in health and diseases DOI Creative Commons
Shizhen Zhang, Qing Yu, Zhijian Li

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: April 4, 2024

Abstract NEDD8 (Neural precursor cell expressed developmentally downregulated protein 8) is an ubiquitin-like that covalently attached to a lysine residue of substrate through process known as neddylation, catalyzed by the enzyme cascade, namely activating (E1), conjugating (E2), and ligase (E3). The substrates neddylation are categorized into cullins non-cullin proteins. Neddylation activates CRLs (cullin RING ligases), largest family E3 ligases, whereas alters their stability activity, well subcellular localization. Significantly, pathway and/or many abnormally activated or over-expressed in various human diseases, such metabolic disorders, liver dysfunction, neurodegenerative cancers, among others. Thus, targeting becomes attractive strategy for treatment these diseases. In this review, we first provide general introduction on its biochemical regulation, crystal structures enzymes complex with cullin substrates; then discuss how governs key biological processes via modification substrates. We further review literature data dysregulated several particularly cancer, followed outline current efforts discovery small molecule inhibitors promising therapeutic approach. Finally, few perspectives were proposed extensive future investigations.

Language: Английский

Citations

43
Jieduquyuziyin prescription alleviates lupus development via inhibiting neddylation pathway to promote Bim-induced apoptosis of double negative T cells DOI
Yiping Li,

Qingchi Duan,

Chenxi Wang

et al.

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: unknown, P. 118884 - 118884

Published: Oct. 1, 2024

Language: Английский

Citations

5
Camk2n1 deficiency reduces the NaCl cotransporter activity through the CUL3/KLHL3/WNK4 complex in the kidney DOI
Ya Zhang, Zihao Zhang, Gengru Jiang

et al.

European Journal of Pharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 177270 - 177270

Published: Jan. 1, 2025

Language: Английский

Citations

0
Systemic lupus erythematosus: updated insights on the pathogenesis, diagnosis, prevention and therapeutics DOI Creative Commons
Xiaofeng Dai, Yuting Fan, Xiaofeng Zhao

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2025, Volume and Issue: 10(1)

Published: March 17, 2025

Abstract Systemic lupus erythematosus (SLE) is a chronic inflammatory illness with heterogeneous clinical manifestations covering multiple organs. Diversified types of medications have been shown effective for alleviating SLE syndromes, ranging from cytokines, antibodies, hormones, molecular inhibitors or antagonists, to cell transfusion. Drugs developed treating other diseases may benefit patients, and agents established as therapeutics be SLE-inductive. Complexities regarding render it essential urgent identify the mechanisms-of-action pivotal signaling axis driving pathogenesis, establish innovative SLE-targeting approaches desirable therapeutic outcome safety. After introducing research history its epidemiology, we categorized primary determinants pathogenesis by their mechanisms; combed through current knowledge on diagnosis grouped them disease onset, activity comorbidity; introduced genetic, epigenetic, hormonal environmental factors predisposing SLE; comprehensively preventive strategies available according functioning mechanisms. In summary, proposed three mechanisms determinant roles initiation progression, i.e., attenuating immune system, restoring cytokine microenvironment homeostasis, rescuing impaired debris clearance machinery; provided updated insights understandings diagnosis, prevention therapeutics, which open an avenue in fields management.

Language: Английский

Citations

0
An increase in IL-10-producing DNT cells is associated with the pathogenesis of pediatric SLE DOI
Qixin Wang, Shipeng Li, Yi Wei

et al.

Clinical Immunology, Journal Year: 2025, Volume and Issue: unknown, P. 110490 - 110490

Published: March 1, 2025

Language: Английский

Citations

0
A novel IgD-FcδR blocker, IgD-Fc-Ig fusion protein, effectively alleviates abnormal activation of T cells the disease progression in systemic lupus erythematosus DOI

Jingjing He,

Danyan Liu, Li Jiang

et al.

Biochemical Pharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 116930 - 116930

Published: April 1, 2025

Language: Английский

Citations

0
Neddylation modification stabilizes LC3B by antagonizing its ubiquitin-mediated degradation and promoting autophagy in skin DOI Creative Commons
Linlin Xu, Xinxing Lyu, Yibo Wang

et al.

Proceedings of the National Academy of Sciences, Journal Year: 2025, Volume and Issue: 122(15)

Published: April 10, 2025

The Atg8-family proteins, including LC3B (microtubule-associated protein 1 light chain 3 beta), are pivotal for key steps in the autophagy process. Proper regulation of homeostasis is essential its function. Although modulated by various posttranslational modifications (PTMs), impact these on remains unclear. Neddylation, a recently identified ubiquitin-like modification, plays diverse biological roles. Here, we identify as specific target neddylation. This modification weakens LC3B’s interaction with ubiquitin E3 ligases VHL and BIRC6, thereby reducing ubiquitination. Depletion ubiquitin-conjugating enzyme E2M (UBE2M), primary E2 neddylation pathway, destabilizes suppresses activity. Heterozygous Ube2m knockout ( +/− ) mice exhibit pronounced aging-like phenotypes, reduced expression impaired skin tissues. Our findings demonstrate that vital maintaining stability regulating flux, offering potential therapeutic avenue to mitigate aging-related processes.

Language: Английский

Citations

0
Immune cells in systemic lupus erythematosus: biology and traditional Chinese medicine therapy DOI
Yuying Liang, Chen Luo, Qingyu Huang

et al.

Acta Pharmacologica Sinica, Journal Year: 2025, Volume and Issue: unknown

Published: April 17, 2025

Language: Английский

Citations

0
NAE1 protein: a prognostic, immunomodulatory, and therapeutic biomarker associated with neddylation in hepatocellular carcinoma DOI
Yong Pan,

Jinyao Dai,

Yi Liu

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 310, P. 143539 - 143539

Published: April 28, 2025

Language: Английский

Citations

0
Flavokawain B ameliorates depressive-like behaviors by inhibiting neddylation in the ventral hippocampus DOI
Shuting Luo,

Zihan Qi,

Feilong Wu

et al.

Neuropharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 110508 - 110508

Published: May 1, 2025

Language: Английский

Citations

0