International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(2), P. 788 - 788
Published: Jan. 18, 2025
Diets
rich
in
carbohydrate
and
saturated
fat
contents,
when
combined
with
a
sedentary
lifestyle,
contribute
to
the
development
of
obesity
metabolic
syndrome
(MetS),
which
subsequently
increase
palmitic
acid
(PA)
levels.
At
high
concentrations,
PA
induces
lipotoxicity
through
several
mechanisms
involving
endoplasmic
reticulum
(ER)
stress,
mitochondrial
dysfunction,
inflammation
cell
death.
Nevertheless,
there
are
endogenous
strategies
mitigate
PA-induced
its
unsaturation
elongation
channeling
storage
lipid
droplets
(LDs),
plays
crucial
role
sequestering
oxidized
lipids,
thereby
reducing
oxidative
damage
membranes.
While
extended
exposure
promotes
reactive
oxygen
species
(ROS)
generation
leading
damage,
acute
ß-cells
increases
glucose-stimulated
insulin
secretion
(GSIS),
activation
free
fatty
receptors
(FFARs).
Subsequently,
FFARs
by
exogenous
agonists
has
been
suggested
as
potential
therapeutic
strategy
prevent
ß
cells.
Moreover,
some
acids,
including
oleic
acid,
can
counteract
negative
impact
on
cellular
health,
suggesting
complex
interaction
between
different
dietary
fats
outcomes.
Therefore,
challenge
is
peroxidation
unsaturated
acids
utilization
natural
antioxidants.
This
complexity
indicates
necessity
for
further
research
into
function
diverse
pathological
conditions
find
main
target
against
lipotoxicity.
The
aim
this
review
is,
therefore,
examine
recent
data
regarding
mechanism
underlying
order
identify
that
promote
protection
lipotoxicity,
dysfunction
apoptosis
MetS
obesity.
Trends in Biochemical Sciences,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 1, 2025
The
majority
of
eukaryotic
proteins
undergo
N-terminal
(Nt)
modifications
facilitated
by
various
enzymes.
These
enzymes,
which
target
the
initial
amino
acid
a
polypeptide
in
sequence-dependent
manner,
encompass
peptidases,
transferases,
cysteine
oxygenases,
and
ligases.
Nt
-
such
as
acetylation,
fatty
acylations,
methylation,
arginylation,
oxidation
enhance
proteome
complexity
regulate
protein
targeting,
stability,
complex
formation.
Modifications
at
N
termini
are
thereby
core
components
large
number
biological
processes,
including
cell
signaling
motility,
autophagy
regulation,
plant
animal
oxygen
sensing.
Dysregulation
Nt-modifying
enzymes
is
implicated
several
human
diseases.
In
this
feature
review
we
provide
an
overview
occurring
either
co-
or
post-translationally,
involved,
impact.
Journal of Biomedical Science,
Journal Year:
2025,
Volume and Issue:
32(1)
Published: Feb. 12, 2025
Diabetic
neuropathy
(DN)
is
a
prevalent
and
painful
complication
of
diabetes;
however,
the
mechanisms
underlying
its
pathogenesis
remain
unclear,
effective
clinical
treatments
are
lacking.
This
study
aims
to
explore
role
peroxisomes
in
Schwann
cells
DN.
The
abundance
sciatic
nerves
mice
or
was
analyzed
using
laser
confocal
super-resolution
imaging
western
blotting.
RFP-GFP-SKL
(Ser-Lys-Leu)
probe
utilized
assess
pexophagy
(peroxisomes
autophagy)
levels.
To
evaluate
palmitoylation
PEX11B,
acyl-resin
assisted
capture
(acyl-RAC)
assay
Acyl-Biotin
Exchange
(ABE)
were
employed.
Additionally,
MR
(Mendelian
randomization)
analysis
conducted
investigate
potential
causal
relationship
between
DN
MS
(Multiple
sclerosis).
There
decrease
peroxisomal
diabetic
mice,
palmitic
acid
(PA)
induced
reduction
by
inhibiting
biogenesis
cells.
Mechanistically,
PA
PEX11B
at
C25
site,
disrupting
self-interaction
impeding
peroxisome
elongation.
Fenofibrate,
PPARα
agonist,
effectively
rescued
dysfunction
caused
restored
mice.
Lastly,
indicates
notable
influence
on
MS,
with
onset
progression
intricately
linked
dysfunction.
Targeting
pathway
may
be
an
strategy
for
preventing
treating
DN,
underscoring
importance
addressing
risk
Frontiers in Nutrition,
Journal Year:
2024,
Volume and Issue:
11
Published: Sept. 4, 2024
Patients
with
cancer
frequently
exhibit
alterations
in
serum
lipid
profiles
associated
chemotherapy.
It
has
been
reported
that
distribution
correlates
tumor
progression.
However,
the
prognostic
value
of
biomarkers
survivors
remains
a
subject
debate.
We
aim
to
explore
relationship
between
non-high-density
lipoprotein
high-density
ratio
(NHHR)
and
prognosis
survivors.
Journal of Agricultural and Food Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 3, 2025
Conjugated
linoleic
acid
(CLA)
is
known
for
antiobesity.
However,
the
role
of
CLA
in
regulating
high-fat
diet
(HFD)-impaired
pubertal
mammary
gland
development
remains
undefined.
Here,
female
mice
and
HC11
cells
were
treated
with
HFD
or
palmitic
(PA),
supplemented
without
CLA,
respectively.
We
found
that
prevented
impaired
exposed
to
HFD.
In
vitro,
c9,
t11-CLA,
but
not
t10,
c12-CLA,
promoted
PA-suppressed
proliferation,
accompanied
by
hindered
CD36
palmitoylation
localization
on
plasma
membrane.
Moreover,
t11-CLA
reduced
formation
CD36/Fyn/Lyn
complex
inhibited
JNK
pathway
while
activated
ERK
PA-treated
HC11.
mechanism,
activation
inhibition
abolished
t11-CLA-stimulated
proliferation
vivo
verification,
total
cell
membrane
palmitoylation,
suppressed
CD36/FYN/LYN
complex,
HFD-fed
mice.
conclusion,
mitigated
HFD-impaired
via
downstream
JNK–ERK
pathway.
These
data
suggested
potential
application
ameliorating
obesity-impaired
development.
