Comparison of Renal Tubular Damage with Kidney Injury Molecule-1 in Open and Laparoscopic Colorectal Cancer Surgery DOI Creative Commons
Abdullah Gürhan Duyan, Celalettın Vatansev, Rahim Kocabaş

et al.

Medicina, Journal Year: 2024, Volume and Issue: 61(1), P. 42 - 42

Published: Dec. 30, 2024

Background and Objectives: Colorectal cancer is the third most common type of in men women. With advancements technology, minimally invasive treatment options have become increasingly prominent colorectal surgery. This study aimed to compare increased intra-abdominal pressure laparoscopic colon rectal surgery with open procedures using kidney injury molecule-1 (KIM-1) secreted from renal tubules. Materials Methods: We enrolled 46 patients diagnosed who underwent surgical at our clinic. The were prospectively randomized into five groups: 10 right hemicolectomies (Group 1), 8 2), anterior resections (LARs) 3), 11 4), 9 low 5). Urine samples collected preoperatively, postoperatively 4th hour, on 14th day, urine KIM-1 levels creatinine (Cr) values measured. KIM-1/Cr ratios subsequently calculated. Results: urinary postoperative hour after procedures. On day 14, lower than those preoperative period all groups, except LAR group. Conclusions: Our shown that average did not a long-term impact comparison

Language: Английский

Neoadjuvant chemoradiation with or without PD-1 blockade in locally advanced rectal cancer: a randomized phase 2 trial DOI
Yingchi Yang,

Kai Pang,

Guole Lin

et al.

Nature Medicine, Journal Year: 2025, Volume and Issue: 31(2), P. 449 - 456

Published: Jan. 6, 2025

Language: Английский

Citations

2
TREM2 scFv‐Engineering Escherichia coli Displaying Modulation of Macrophages to Boost Cancer Radio‐Immunotherapy DOI Open Access
Yifan Wang, Anqi Dong,

Jianping Man

et al.

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 19, 2025

Abstract Preoperative neoadjuvant radio‐chemotherapy is a cornerstone in the treatment of low rectal cancer, yet its effectiveness can be limited by insensitivity some patients, profoundly impacting their quality life. Through preliminary research, it found that TREM2 + macrophages play pivotal role non‐responsiveness to immunotherapy. To address this challenge, novel ionizing radiation‐responsive delivery system developed for precise expression anti‐TREM2 single‐chain antibody fragments (scFv) using an engineered probiotic, Escherichia coli Nissle 1917 (EcN), modulate The released scFv precisely targeted and delivered tumor site via EcN outer membrane vesicles (OMVs), thereby reversing immunosuppressive microenvironment enhancing therapeutic efficiency when used combination with αPD‐L1 immune checkpoint inhibitor. Additionally, these bacteria further modified enhance intestinal colonization capabilities through oral administration, regulating gut microbiota metabolic byproducts. Consequently, drug based on not only introduces promising new option cancer but also showcases potential finely tune responses within intricate microenvironment, paving way innovative strategies radio‐immunotherapy.

Language: Английский

Citations

2
Inhibition of PCSK9: a promising enhancer for anti-PD-1/PD-L1 immunotherapy DOI Creative Commons

Shengbo Sun,

Jingxin Ma,

Tingting Zuo

et al.

Research, Journal Year: 2024, Volume and Issue: 7

Published: Jan. 1, 2024

Immune checkpoint therapy, such as programmed cell death protein 1/programmed death-ligand 1 (PD-1/PD-L1) blockade, has achieved remarkable results in treating various tumors. However, most cancer patients show a low response rate to PD-1/PD-L1 especially those with microsatellite stable/mismatch repair-proficient colorectal subtypes, which indicates an urgent need for new approaches augment the efficacy of blockade. Cholesterol metabolism, involves generating multifunctional metabolites and essential membrane components, is also instrumental tumor development. In recent years, inhibiting proprotein convertase subtilisin/kexin type 9 (PCSK9), serine proteinase that regulates cholesterol been demonstrated be method enhancing antitumor effect blockade some extent. Mechanistically, PCSK9 inhibition can maintain recycling major histocompatibility class I, promote low-density lipoprotein receptor-mediated T-cell receptor signaling, modulate microenvironment (TME) by affecting infiltration exclusion immune cells. These mechanisms increase quantity enhance antineoplastic cytotoxic T lymphocyte, main functional cells involved anti-PD-1/PD-L1 immunotherapy, TME. Therefore, combining therapy immunotherapy may provide novel option improving effects constitute promising research direction. This review concentrates on relationship between systematically discusses how potentiates treatment, highlights directions this field.

Language: Английский

Citations

5
IDO1 inhibitor enhances the effectiveness of PD-1 blockade in microsatellite stable colorectal cancer by promoting macrophage pro-inflammatory phenotype polarization DOI Creative Commons

Lv Guangzhao,

Xin Wang,

Wu Miaoqing

et al.

Cancer Immunology Immunotherapy, Journal Year: 2025, Volume and Issue: 74(2)

Published: Jan. 3, 2025

Microsatellite stable (MSS) colorectal cancer (CRC) is a subtype of CRC that generally exhibits resistance to immunotherapy, particularly immune checkpoint inhibitors such as PD-1 blockade. This study investigates the effects and underlying mechanisms combining blockade with IDO1 inhibition in MSS CRC. Bioinformatics analyses TCGA-COAD TCGA-READ cohorts revealed significantly elevated expression tumors, correlating tumor mutation burden across TCGA datasets. In vivo experiments demonstrated combination reduced growth increased cell infiltration, pro-inflammatory macrophages CD8+ T cells. knockdown lines impaired tolerance interferon-γ apoptosis vitro, which were rescued by application kynurenine, end product IDO1. enhanced effectiveness therapy vivo. cells promoted macrophage polarization phagocytic activity associated upregulation JAK2-STAT3-IL6 signaling pathway. These findings highlight role modulating microenvironment suggest could enhance therapeutic efficacy promoting infiltration through

Language: Английский

Citations

0
Phenotypic plasticity and increased infiltration of peripheral blood-derived TREM1+ mono-macrophages following radiotherapy in rectal cancer DOI
Haihong Wang,

Menglan Zhai,

Mingjie Li

et al.

Cell Reports Medicine, Journal Year: 2025, Volume and Issue: unknown, P. 101887 - 101887

Published: Jan. 1, 2025

Language: Английский

Citations

0
A Novel Gene Signature for Predicting Outcome in Colorectal Cancer Patients Based on Tumor Cell-Endothelial Cell Interaction via Single-Cell Sequencing and Machine Learning DOI Creative Commons

Lina Pang,

Qi Sun, Wenyue Wang

et al.

Heliyon, Journal Year: 2025, Volume and Issue: unknown, P. e42237 - e42237

Published: Jan. 1, 2025

Language: Английский

Citations

0
Combining gut microbiota modulation and immunotherapy: A promising approach for treating microsatellite stable colorectal cancer DOI

Yujie Chang,

Min Long,

Hanguo Shan

et al.

Critical Reviews in Oncology/Hematology, Journal Year: 2025, Volume and Issue: 208, P. 104629 - 104629

Published: Jan. 27, 2025

Language: Английский

Citations

0
Neoadjuvant therapy for colorectal cancer from 2015 to 2024: a visual analysis and bibliometric analysis DOI Creative Commons

Boyu Kang,

Yihuan Qiao,

Junyong Zhu

et al.

Frontiers in Oncology, Journal Year: 2025, Volume and Issue: 15

Published: April 2, 2025

Colorectal cancer (CRC) imposes a substantial burden on global health., but research trends and hotspots in this field are still not clear. The purpose of is to create visual knowledge map based bibliometric analysis, identify predict future trends. Utilizing the Web Science Core Collection (WoSCC) as data source integrating visualization capabilities Bibliometrix R software package, CiteSpace, VOSviewer, analyze authors, institutions, countries, cited documents, publishing journals, abstracts, keyword information literature pertaining neoadjuvant therapy for colorectal spanning from January 2015 December 2024. analysis included 1,587 articles 1,464 385 61 countries or regions. China has largest number publications (449) citations (5,035). United States occupies leading position with an average 21.6. "Annals Surgical Oncology" most published journal 51 articles, "Journal Clinical references (4,465 references). Highly focus clinical trials guidelines cancer. In recent years, important keywords have been "artificial intelligence", "total therapy" "immunotherapy". This article provided review cancer, can provide reference subsequent results offered valuable insights that informed direction advancements.

Language: Английский

Citations

0
Comparison of immunotherapy based total neoadjuvant therapy or standard neoadjuvant chemoradiation for locally advanced rectal cancer: a multi-institutional retrospective study DOI Creative Commons
Zhao Wen, Wenxing Gao,

Jitao Du

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: April 14, 2025

Background Combining radiation therapy with immunotherapy produces a synergistic effect in patients microsatellite stable/mismatch repair-proficient (MSS/pMMR) locally advanced rectal cancer (LARC). This study aimed to evaluate the long-term outcomes and safety of combined long-course chemoradiotherapy (ICIs + nCRT) versus total neoadjuvant TNT). Methods retrospective collected clinical data adult T3-4 and/or N1 adenocarcinoma who underwent ICIs TNT or nCRT followed by curative surgery at four medical centers between March 2020 August 2021. The compared efficacy, disease-free survival (DFS), overall (OS) 3 years postoperatively, adverse event. Results Among 211 enrolled patients, 89 (42%) received TNT, while 122 (58%) nCRT, median age 56.0 (range, 20.0-75.0 years). group had higher number resected lymph nodes (15.0 [range, 4.0-37.0] vs. 13.0 3.0-33.0], P =0.028) ICIs+nCRT group. However, groups no substantial difference operative time. pathological complete response (pCR) rate was 49.4% (44/89, 95% confidence interval [CI] 39.8%-61.3%) 35.3% (43/122, CI 26.8%-44.4%) group, respectively, significant ( =0.039). After adjusting for potential confounders, 3-year DFS rates were comparable two (84.3% 81.9%; =0.620), as OS (94.0% 91.1%; =0.634). Factors independently associated poorer included ≤50 =0.044) (NAR) score ≥8 =0.008). Similarly, aged =0.025) exhibited trend toward worse than those older 50 years. profiles treatment similar. Conclusions Overall, demonstrated therapeutic efficacy profile LARC MSS/pMMR status. Although achieved numerically downstaging rates, it not improved outcomes. These findings underscore importance refining patient selection criteria making judicious decisions enhance prognosis individuals cancer.

Language: Английский

Citations

0
Plasma proteome and metabolites profiling reveals dynamics for adverse events and responses after neoadjuvant radiochemotherapy plus PDL1 blockade in microsatellite-stable locally advanced rectal cancer: A prospective longitudinal study DOI
Jianmin Xu, Yang Lv, Zhehui Zhu

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: May 7, 2025

Abstract Neoadjuvant radio-chemotherapy (nCRT) plus immune checkpoint inhibitors (ICIs) have emerged as an effective antitumor regimen for locally advanced rectal cancer. Yet, few biomarkers are developed to monitor the therapy response. Herein, we investigate longitudinal plasma proteome and metabolites profiling including 117 samples from 50 patients who received nCRT PDL1 blockade therapy. Notably, cholesterol metabolism is activated in disease non-response group during Correspondingly, 1,4-cholestadienone, 7-methyloctanoylcarnitine 3-hydroxybutyrylcarnitine, ABCA13, RAB3IP, GBA2 show significantly positive association with metabolism. Furthermore, by integrating approach, identify a candidate metabolite (phosphatidylcholine, cholest-5-en-23-yn-3beta-ol) (APBB1IP, OLFM4, DNAJC19) that can reflect Above, establish machine learning model predict response, performance validated repeated group-to-group validation accuracy 0.954. Thus, strategy evaluate alteration of identifies panel biomarkers.

Language: Английский

Citations

0