Housing temperature influences exercise‐induced glucose regulation and expression of exerkines in mice DOI Creative Commons
Zhijian Rao, Xue Geng, Peng Huang

et al.

Experimental Physiology, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 25, 2024

Abstract The impact of housing temperature on exercise‐induced metabolic adaptations is not well understood, despite extensive research the benefits exercise for health. aim this study was to elucidate how temperatures influence molecular responses and in mice. Male C57BL/6N mice were housed at either room (RT, 21°C) or a thermoneutral environment (TN, 29°C) subjected 6‐week acute regimen. results demonstrated that chronic TN conditions significantly improved glucose tolerance, whereas no such improvement observed RT conditions. Exercise reduced adipocyte size inguinal epididymal white adipose tissue conditions, but significant browning detected temperature. Additionally, predominantly influenced key proteins skeletal muscle, with exhibiting interactive effects glycogen synthase, Glut4 Pgc‐1α. Moreover, regulation exerkines, including Fgf21, fetuin‐A, irisin, Gdf15, spexin apelin, dependent after both long‐term exercise. Notably, expression Metrnl consistently upregulated muscle environments, downregulated These findings highlight environmental critically modulates exerkines. suggest conventional might obscure full We recommend use future reduce confounding factors provide more accurate assessment

Language: Английский

The effect of physical activity on markers of oxidative and antioxidant stress in cancer patients: a systematic review and meta-analysis DOI Creative Commons
Laerte Jônatas Leray Guedes, Victória Brioso Tavares, Saúl Rassy Carneiro

et al.

BMC Cancer, Journal Year: 2025, Volume and Issue: 25(1)

Published: Jan. 13, 2025

Prescribing physical exercise as part of the clinical treatment cancer patients has become an important strategy in therapeutic arsenal available main health centers specialized neoplastic diseases, but there is still uncertainty regarding role regular activity modifying oxidative stress markers and antioxidants, high levels can lead to development carcinogens. Therefore, we assessed effect versus absence on antioxidants patients. We looked for randomized controlled trials that included adult with any type performing some compared them a control group no activity. The outcomes interest collected were antioxidants. Six databases used search (EMBASE, Cochrane Library (CENTRAL), US National Medicine (PubMed), Physiotherapy Evidence Database (PEDro), Cumulative Index Nursing Allied Health (CINAHL) SPORTDiscus via EBSCO) until January 31st, 2024. In end, 7 included, totaling 573 participants. It was possible conduct meta-analysis demonstrated potentially increases antioxidant marker Trolox, Taoc, Gpx, (SMD = 1.23, CI: 0.13 2.34). However, these findings classified having very low moderate GRADE evidence. Cancer who participated programs may have exhibited increased concentration Although overall quality evidence studies low, represent field research should be guided by more participants homogeneous methods analysis oxidant markers. PROSPERO CRD42021257815.

Language: Английский

Citations

1
Evolution of resistance training in women: History and mechanisms for health and performance DOI Creative Commons
William J. Kraemer, Maren S. Fragala, Nicholas A. Ratamess

et al.

Sports Medicine and Health Science, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

Citations

1
Irisin's emerging role in Parkinson's disease research: A review from molecular mechanisms to therapeutic prospects DOI Creative Commons

Ruqing Qiu,

Weilu Sun,

Yana Su

et al.

Life Sciences, Journal Year: 2024, Volume and Issue: 357, P. 123088 - 123088

Published: Sept. 30, 2024

Language: Английский

Citations

4
Actividad física y mortalidad: una revisión sistemática y metaanálisis de estudios longitudinales DOI Creative Commons
Guadalupe Simanga Ivett Robles Hernández, Karla Juanita Montes Mata, Juan Francisco Aguirre Chávez

et al.

Retos, Journal Year: 2025, Volume and Issue: 64, P. 137 - 150

Published: Jan. 13, 2025

Introducción: este estudio examina la relación entre actividad física y mortalidad por todas las causas. La revisión incluye estudios longitudinales que evalúan cómo los niveles de impactan a lo largo del tiempo. Objetivo: determinar asociación reducción riesgo causas mediante una sistemática metaanálisis relevantes. Metodología: se realizó búsqueda exhaustiva en bases datos científicas para identificar relevantes, aplicaron criterios inclusión requerían el uso cuestionarios validados mortalidad. Resultados: resultados indican más altos están significativamente asociados con En comparación individuos baja física, aquellos alta mostraron 20-30%. Además, observó incluso incrementos modestos resultan beneficios considerables salud. Conclusiones: confirman regular es estrategia clave reducir Las políticas salud pública deben enfocarse facilitar acceso oportunidades realizar ejercicio fomentar estilos vida activos maximizar estos

Citations

0
Enhancing sleep quality in synucleinopathies through physical exercise DOI Creative Commons
Jacopo Canonichesi, Laura Bellingacci,

Francesco Rivelli

et al.

Frontiers in Cellular Neuroscience, Journal Year: 2025, Volume and Issue: 19

Published: Jan. 31, 2025

During sleep, several crucial processes for brain homeostasis occur, including the rearrangement of synaptic connections, which is essential memory formation and updating. Sleep also facilitates removal neurotoxic waste products, accumulation plays a key role in neurodegeneration. Various neural components environmental factors regulate influence physiological transition between wakefulness sleep. Disruptions this complex system form basis sleep disorders, as commonly observed synucleinopathies. Synucleinopathies are neurodegenerative disorders characterized by abnormal build-up α-synuclein protein aggregates brain. This different regions leads to spectrum clinical manifestations, hypokinesia, cognitive impairment, psychiatric symptoms, neurovegetative disturbances. highly prevalent individuals with synucleinopathies, they not only affect overall well-being patients but directly contribute disease severity progression. Therefore, it develop effective therapeutic strategies improve quality these patients. Adequate vital health, synucleinopathies disrupting patterns must be taken into account. In context, explore physical exercise potential non-pharmacological intervention manage The current evidence on efficacy programs enhance patient population discussed.

Language: Английский

Citations

0
Harnessing exercise to combat chronic diseases: the role of Drp1-Mediated mitochondrial fission DOI Creative Commons
Yingxin Sun,

Junchen He,

Lei Bao

et al.

Frontiers in Cell and Developmental Biology, Journal Year: 2025, Volume and Issue: 13

Published: Feb. 26, 2025

Enhanced Drp1 activity mediates excessive mitochondrial fission, contributing to the onset and progression of various chronic diseases, including neurodegenerative, cardiovascular, metabolic disorders. Studies indicate that exercise mitigates dysfunction by modulating Drp1-related signaling targets, thereby inhibiting reducing fission. This, in turn, enhances function cellular metabolism. This review synthesizes current understanding structure activation mechanisms, analyzes effects interventions on Drp1-mediated fission different disease models improve common conditions. research deepens our insight into specific mechanisms Drp1-induced pathogenesis, offering new theoretical support practical guidance for as a non-pharmacological intervention strategy.

Language: Английский

Citations

0
THE ROLE OF MYOKINES IN IMPROVING COGNITIVE FUNCTION DOI Creative Commons
A.I. Petrova, Александр Викторович Марковский, Н. Л. Потапова

et al.

Zabajkalʹskij medicinskij vestnik, Journal Year: 2025, Volume and Issue: 4, P. 126 - 132

Published: Feb. 25, 2025

Over the past couple of decades, it has become apparent that skeletal muscles work as an endocrine organ can produce and secrete myokines exert their effects in endocrine, paracrine, or autocrine manner. Modern research shows physical exertion induces synthesis molecules involved transmission signals between muscle cells other organs, particular brain, adipose tissue, organs gastrointestinal tract, well skin vascular cells. This review examines cause communication with neuroprotection response to activity related processes. Unlike exercise-induced protective signaling pathways, inactivity wasting disrupt expression secretion and, turn, function central nervous system. It is assumed adapting from brain by modulating will help combat age-related neurodegeneration diseases affected systemic signals.

Language: Английский

Citations

0
Exercise, Neuroprotective Exerkines, and Parkinson’s Disease: A Narrative Review DOI Creative Commons

Alexandra K. Mitchell,

Rebecca R. Bliss,

Frank Church

et al.

Biomolecules, Journal Year: 2024, Volume and Issue: 14(10), P. 1241 - 1241

Published: Sept. 30, 2024

Parkinson's disease (PD) is a prevalent neurodegenerative in which treatment often includes an exercise regimen. Exercise neuroprotective animal models of PD, and, more recently, human clinical studies have verified exercise's disease-modifying effect. Aerobic and resistance training improve many PD's motor non-motor symptoms, while neuromotor therapy stretching/flexibility exercises positively contribute to the quality life people with PD. Therefore, understanding role managing this complex disorder crucial. Exerkines are bioactive substances that synthesized released during been implicated several positive health outcomes, including neuroprotection. protect neuronal cells vitro rodent PD vivo. both increase exerkine levels blood, suggesting for exerkines theory. Many demonstrate potential protecting brain against pathological missteps caused by Every person (people) (PwP) needs comprehensive plan tailored their unique abilities. Here, we provide template help PwP understand importance treating describe barriers confronting attempt exercise, suggestions overcoming these barriers, explore In conclusion, together create powerful system should slowing chronic progression

Language: Английский

Citations

3
‘Exerkines’: A Comprehensive Term for the Factors Produced in Response to Exercise DOI Creative Commons
Giuseppe Novelli,

Giuseppe Calcaterra,

Federico Casciani

et al.

Biomedicines, Journal Year: 2024, Volume and Issue: 12(9), P. 1975 - 1975

Published: Sept. 1, 2024

Regular exercise and physical activity are now considered lifestyle factors with positive effects on human health. Physical reduces disease burden, protects against the onset of pathologies, improves clinical course disease. Unlike pharmacological therapies, mediated by not limited to a specific target organ but act in multiple biological systems simultaneously. Despite substantial health benefits training, precise molecular signaling processes that lead structural functional tissue adaptation remain largely unknown. Only recently, several bioactive molecules have been discovered produced following exercise. These collectively called “exerkines”. Exerkines released from various tissues response exercise, play crucial role mediating beneficial body. Major discoveries involving exerkines highlight their diverse functions implications, particularly metabolic regulation, neuroprotection, muscle adaptation. molecules, including peptides, nucleic acids, lipids, microRNAs, through paracrine, endocrine, autocrine pathways exert organs tissues. represent complex network mediate Their roles importance maintaining preventing

Language: Английский

Citations

2
Metaanálisis sobre los beneficios de la actividad física regular en la prevención de enfermedades crónicas (Meta-analysis on the benefits of regular physical activity in the prevention of chronic diseases) DOI Creative Commons
Juan Francisco Aguirre Chávez, Jesús Roberto Aguirre López, Guadalupe Simanga Ivett Robles Hernández

et al.

Retos, Journal Year: 2024, Volume and Issue: 59, P. 822 - 831

Published: Aug. 5, 2024

La actividad física regular es un componente fundamental de estilos vida saludable y desempeña papel crucial en la prevención enfermedades crónicas. Este estudio revisa evidencia científica que respalda los beneficios como cardiovascular, diabetes tipo 2, obesidad, hipertensión ciertos tipos cáncer. mejora perfiles lipídicos, reduce presión arterial función endotelial, lo disminuye el riesgo enfermedad cardiovascular. En cuanto a ejercicio aumenta sensibilidad insulina ayuda controlar niveles glucosa sangre. Además, física, al incrementar gasto energético, manejo factor significativo para muchas El significativamente desarrollar cáncer, del colon mama, través mecanismos regulación hormonal, reducción inflamación sistema inmunológico. Fomentar práctica debería ser una prioridad las políticas salud pública reducir carga global crónicas mejorar calidad población. Palabras clave: física; crónicas; Prevención; cardiovascular; 2; Obesidad; Hipertensión; Cáncer. Abstract. Regular physical activity is component of healthy lifestyle and plays role in the prevention chronic diseases. This study reviews scientific evidence supporting benefits preventing diseases such as cardiovascular disease, type 2 diabetes, obesity, hypertension, certain types cancer. Physical improves lipid profiles, reduces blood pressure, enhances endothelial function, thereby decreasing risk disease. Regarding exercise increases insulin sensitivity helps control glucose levels. Additionally, activity, by increasing energy expenditure, essential management significant for many significantly pressure lowers developing cancer, breast through mechanisms hormonal regulation, inflammation reduction, immune system enhancement. Promoting should be priority public health policies to burden improve population's quality life. Keywords: activity; diseases; prevention; health; diabetes; Obesity; Hypertension; Cancer.

Citations

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