Experimental Physiology,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 25, 2024
Abstract
The
impact
of
housing
temperature
on
exercise‐induced
metabolic
adaptations
is
not
well
understood,
despite
extensive
research
the
benefits
exercise
for
health.
aim
this
study
was
to
elucidate
how
temperatures
influence
molecular
responses
and
in
mice.
Male
C57BL/6N
mice
were
housed
at
either
room
(RT,
21°C)
or
a
thermoneutral
environment
(TN,
29°C)
subjected
6‐week
acute
regimen.
results
demonstrated
that
chronic
TN
conditions
significantly
improved
glucose
tolerance,
whereas
no
such
improvement
observed
RT
conditions.
Exercise
reduced
adipocyte
size
inguinal
epididymal
white
adipose
tissue
conditions,
but
significant
browning
detected
temperature.
Additionally,
predominantly
influenced
key
proteins
skeletal
muscle,
with
exhibiting
interactive
effects
glycogen
synthase,
Glut4
Pgc‐1α.
Moreover,
regulation
exerkines,
including
Fgf21,
fetuin‐A,
irisin,
Gdf15,
spexin
apelin,
dependent
after
both
long‐term
exercise.
Notably,
expression
Metrnl
consistently
upregulated
muscle
environments,
downregulated
These
findings
highlight
environmental
critically
modulates
exerkines.
suggest
conventional
might
obscure
full
We
recommend
use
future
reduce
confounding
factors
provide
more
accurate
assessment
European Journal of Immunology,
Journal Year:
2024,
Volume and Issue:
54(12)
Published: Sept. 30, 2024
Adrenergic
receptors
(ARs)
are
preferentially
expressed
by
innate
lymphocytes
such
as
natural
killer
(NK)
cells.
Here,
we
study
the
effect
of
epinephrine-mediated
stimulation
β2-adrenergic
receptor
(β2AR)
on
function
human
NK
Epinephrine
inhibited
early
cell
signaling
events
and
blocked
integrin
LFA-1.
This
reduced
adhesion
cells
to
ICAM-1,
explaining
how
mobilized
into
peripheral
blood
upon
epinephrine
release
during
acute
stress
or
exercise.
Additionally,
transiently
degranulation,
serial
killing,
cytokine
production
affected
metabolic
changes
activation
via
cAMP-protein
kinase
A
(PKA)
pathway.
Repeated
exposure
β2AR
agonists
resulted
in
desensitization
a
PKA
feedback
loop-initiated
G-protein
switch.
Therefore,
chronically
stimulated
no
longer
LFA-1
activity.
Sustained
long-acting
β2-agonists
(LABA)
not
only
functions
but
also
β2AR.
However,
from
LABA-treated
asthma
patients
still
reacted
unchanged
stimulation,
demonstrating
that
local
LABA
administration
does
result
detectable
systemic
effects
Experimental Physiology,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 25, 2024
Abstract
The
impact
of
housing
temperature
on
exercise‐induced
metabolic
adaptations
is
not
well
understood,
despite
extensive
research
the
benefits
exercise
for
health.
aim
this
study
was
to
elucidate
how
temperatures
influence
molecular
responses
and
in
mice.
Male
C57BL/6N
mice
were
housed
at
either
room
(RT,
21°C)
or
a
thermoneutral
environment
(TN,
29°C)
subjected
6‐week
acute
regimen.
results
demonstrated
that
chronic
TN
conditions
significantly
improved
glucose
tolerance,
whereas
no
such
improvement
observed
RT
conditions.
Exercise
reduced
adipocyte
size
inguinal
epididymal
white
adipose
tissue
conditions,
but
significant
browning
detected
temperature.
Additionally,
predominantly
influenced
key
proteins
skeletal
muscle,
with
exhibiting
interactive
effects
glycogen
synthase,
Glut4
Pgc‐1α.
Moreover,
regulation
exerkines,
including
Fgf21,
fetuin‐A,
irisin,
Gdf15,
spexin
apelin,
dependent
after
both
long‐term
exercise.
Notably,
expression
Metrnl
consistently
upregulated
muscle
environments,
downregulated
These
findings
highlight
environmental
critically
modulates
exerkines.
suggest
conventional
might
obscure
full
We
recommend
use
future
reduce
confounding
factors
provide
more
accurate
assessment
