Trends in cancer, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 1, 2024
Language: Английский
Cells, Journal Year: 2025, Volume and Issue: 14(7), P. 511 - 511
Published: March 29, 2025
Oxidative stress (OS) is an established hallmark of cancer and neurodegenerative disorders (NDDs), which contributes to genomic instability neuronal loss. This review explores the contrasting role OS in stem cells (CSCs) NDDs. Elevated levels reactive oxygen species (ROS) contribute promote tumor initiation progression CSCs, while NDDs such as Alzheimer’s Parkinson’s disease, accelerates death impairs cellular repair mechanisms. Both scenarios involve disruption delicate balance between pro-oxidant antioxidant systems, leads chronic oxidative stress. Notably, CSCs neurons display alterations redox-sensitive signaling pathways, including Nrf2 NF-κB, influence cell survival, proliferation, differentiation. Mitochondrial dynamics further illustrate these differences: enhanced function supports adaptability whereas impairments heighten vulnerability. Understanding common mechanisms OS-induced redox imbalance may provide insights for developing interventions, addressing aging hallmarks, potentially mitigating or preventing both
Language: Английский
Citations
5
Cell Biochemistry and Biophysics, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 22, 2025
Language: Английский
Citations
3
Research, Journal Year: 2025, Volume and Issue: 8
Published: Jan. 1, 2025
The intricate relationship between cancer, circadian rhythms, and aging is increasingly recognized as a critical factor in understanding the mechanisms underlying tumorigenesis cancer progression. Aging well-established primary risk for while disruptions rhythms are intricately associated with progression of various tumors. Moreover, itself disrupts leading to physiological changes that may accelerate development. Despite these connections, specific interplay processes their collective impact on remains inadequately explored literature. In this review, we systematically explore influence We discuss how core genes tumor prognosis, highlighting shared hallmarks such genomic instability, cellular senescence, chronic inflammation. Furthermore, examine aging, focusing crosstalk contributes tumorigenesis, proliferation, apoptosis, well metabolism stability. By elucidating common pathways linking review provides new insights into pathophysiology identifies potential therapeutic strategies. propose targeting regulation could pave way novel treatments, including chronotherapy antiaging interventions, which offer important benefits clinical management cancer.
Language: Английский
Citations
3
Cancer Letters, Journal Year: 2024, Volume and Issue: unknown, P. 217350 - 217350
Published: Nov. 1, 2024
Pancreatic cancer remains one of the most challenging malignancies to treat due its late-stage diagnosis, aggressive progression, and high resistance existing therapies. This review examines latest advancements in early detection, therapeutic strategies, with a focus on emerging biomarkers, tumor microenvironment (TME) modulation, integration artificial intelligence (AI) data analysis. We highlight promising including microRNAs (miRNAs) circulating DNA (ctDNA), that offer enhanced sensitivity specificity for early-stage diagnosis when combined multi-omics panels. A detailed analysis TME reveals how components such as cancer-associated fibroblasts (CAFs), immune cells, extracellular matrix (ECM) contribute therapy by creating immunosuppressive barriers. also discuss interventions target these components, aiming improve drug delivery overcome evasion. Furthermore, AI-driven analyses are explored their potential interpret complex data, enabling personalized treatment strategies real-time monitoring response. conclude identifying key areas future research, clinical validation regulatory frameworks AI applications, equitable access innovative comprehensive approach underscores need integrated, outcomes pancreatic cancer.
Language: Английский
Citations
14
MedComm, Journal Year: 2024, Volume and Issue: 5(10)
Published: Sept. 21, 2024
Cancer stem cells (CSCs) are widely acknowledged as the drivers of tumor initiation, epithelial-mesenchymal transition (EMT) progression, and metastasis. Originating from both hematologic solid malignancies, CSCs exhibit quiescence, pluripotency, self-renewal akin to normal cells, thus orchestrating heterogeneity growth. Through a dynamic interplay with microenvironment (TME) intricate signaling cascades, undergo transitions differentiated cancer culminating in therapy resistance disease recurrence. This review undertakes an in-depth analysis multifaceted mechanisms underlying stemness CSC-mediated therapy. Intrinsic factors encompassing TME, hypoxic conditions, oxidative stress, alongside extrinsic processes such drug efflux mechanisms, collectively contribute therapeutic resistance. An exploration into key pathways, including JAK/STAT, WNT, NOTCH, HEDGEHOG, sheds light on their pivotal roles sustaining phenotypes. Insights gleaned preclinical clinical studies hold promise refining discovery efforts optimizing interventions, especially chimeric antigen receptor (CAR)-T cell therapy, cytokine-induced killer (CIK) natural (NK) cell-mediated CSC-targeting others. Ultimately use sorting single sequencing approaches for elucidating fundamental characteristics inherent will enhance our comprehension CSC intratumor heterogeneity, which ultimately would inform about tailored personalized interventions.
Language: Английский
Citations
12
Journal of Nuclear Medicine, Journal Year: 2025, Volume and Issue: 66(1), P. 14 - 19
Published: Jan. 1, 2025
Despite recent therapeutic breakthroughs, cancer patients continue to face high recurrence and mortality rates due treatment resistance. Cancer stem cells (CSCs), a subpopulation with self-renewal capabilities, are key drivers of refractive disease. This review explores the application molecular imaging techniques, such as PET SPECT, for noninvasive detection CSCs. By providing real-time monitoring CSCs, these methods have potential predict therapy resistance guide personalized approaches. Here, we cover biological characteristics mechanisms resistance, identification targeting CSC-specific biomarkers imaging. Additionally, address challenges opportunities clinical translation CSC imaging, highlighting strategies where can be used improve patient outcomes.
Language: Английский
Citations
2
Cancers, Journal Year: 2025, Volume and Issue: 17(2), P. 203 - 203
Published: Jan. 9, 2025
Exposure to radiation and chemicals, oncogenic viruses, microbiomes, inflammation are the major events of cancer initiation. DNA damage chromosomal aberrations classically considered main causes cancer. The recent idea epigenetics is broadening concept, including suggestion that virus infection disrupts various intracellular signaling cascades. Chronic was proposed as origin in 19th century, molecular level has been made clear with scientific development. Much knowledge initiation become available for integration into research. Simultaneously, presence stem cells identified characterized. However, point shift from normal malignant still appears obscure even when taking consideration. From these points view, advent briefly discussed this paper.
Language: Английский
Citations
2
Journal of Controlled Release, Journal Year: 2025, Volume and Issue: 380, P. 269 - 282
Published: Feb. 6, 2025
Language: Английский
Citations
2
Cells, Journal Year: 2025, Volume and Issue: 14(4), P. 286 - 286
Published: Feb. 15, 2025
In the breast tumor microenvironment (TME), adipocytes exert a selective pressure on behavior of cancer stem cells (BCSCs), which are involved in endocrine therapy resistance. obesity, secrete reduced levels adiponectin, promotes growth and progression ERα-positive (BC). Here, we examined how low adiponectin affect enrichment BCSC subpopulation mechanisms contributing to maintenance resistance BC. Flow cytometry, qRT-PCR, Western blotting analysis were performed assess stemness, cell cycle, apoptosis markers MCF-7 wild-type (WT) tamoxifen-resistant (TR) mammospheres. nLC-MS/MS was employed profile compare proteome BCSCs. Differentially expressed proteins intersected with data from MetacoreTM dataset. Our study demonstrated that increased percentage CD44+/CD24-/ALDH1+ stem-like TR Specifically, contributed bulk through slow cycling rate, supported by decreased Cyclin D1 Ki67 p21 p27 expression, escape apoptosis, sustained ROS production preserved mitochondrial membrane potential. results provide new insights into contribution poor BC outcomes. Deeply understanding adiponectin's role stemness may disclose novel therapeutic approaches treat hormone-resistant obese patients.
Language: Английский
Citations
2
Cellular Immunology, Journal Year: 2025, Volume and Issue: 409-410, P. 104931 - 104931
Published: Feb. 20, 2025
Language: Английский
Citations
2