Journal of Cancer,
Journal Year:
2024,
Volume and Issue:
16(3), P. 700 - 707
Published: Dec. 31, 2024
Developing
new
drug
delivery
systems
is
crucial
for
enhancing
the
efficacy
of
oncolytic
virus
(OV)
therapies
in
cancer
treatment.
In
this
study,
mesenchymal
stem
cell
(MSC)-derived
vesicles
and
viruses
are
exploited
to
construct
a
novel
formulation.
It
has
been
hypothesized
that
vesicle-coated
OVs
could
amplify
cytotoxic
effects
through
superior
internalization
by
tumor
cells.
MSC
possess
natural
homing
ability
biocompatibility,
which
can
enhance
targeting,
uptake,
therapeutic
on
Experimental
results
indicated
treatment
system
increased
apoptosis
Furthermore,
flow
cytometry
analysis
demonstrated
uptake
cells
coated
with
soared
away
compared
uncoated
OVs,
being
1.5
times
than
group.
Additionally,
confocal
laser
scanning
microscopy
also
showed
fluorescence
intensity
within
pretreated
MSC-coated
was
greater.
Meanwhile,
propidium
iodide
(PI)
staining
revealed
Ovs
exposed
accelerating
latter.
According
statistics,
number
dead
increased,
testified
OV
group
as
high
23.78%.
These
findings
highlight
potential
therapy,
providing
promising
strategy
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(10), P. 4835 - 4835
Published: May 19, 2025
Extracellular
vesicles
(EVs)
are
lipid
bilayer-enclosed
particles
secreted
by
cells
and
ubiquitously
present
in
various
biofluids.
They
not
only
mediate
intercellular
communication
but
also
serve
as
promising
drug
carriers
that
capable
of
delivering
therapeutic
agents
to
target
through
their
inherent
physicochemical
properties.
In
this
review,
we
summarized
the
recent
advances
EV
isolation
techniques
innovative
drug-loading
strategies.
Furthermore,
emphasized
distinct
advantages
applications
EVs
derived
from
different
cellular
sources
cancer
treatment.
Finally,
critically
evaluated
ongoing
clinical
trials
utilizing
for
delivery
systematically
assessed
both
opportunities
challenges
associated
with
implementing
EV-based
systems
therapy.
Frontiers in Pharmacology,
Journal Year:
2024,
Volume and Issue:
15
Published: Oct. 23, 2024
Malignant
tumors
are
a
category
of
diseases
that
possess
invasive
and
metastatic
capabilities,
with
global
incidence
mortality
rates
remaining
high.
In
recent
years,
the
pivotal
role
fibrosis
in
tumor
progression,
drug
resistance,
immune
evasion
has
increasingly
been
acknowledged.
Fibrosis
enhances
proliferation,
migration,
invasion
cells
by
modifying
composition
structure
extracellular
matrix,
thereby
offering
protection
for
cells.
The
activation
cancer-associated
fibroblasts
(CAFs)
plays
significant
this
process,
as
they
further
exacerbate
malignant
traits
secreting
variety
cytokines
growth
factors.
Anti-fibrotic
treatment
strategies,
including
use
anti-fibrotic
drugs
inhibition
fibrosis-related
signaling
pathways
such
Transforming
Growth
Factor-β
(TGF-β),
have
demonstrated
potential
delaying
progression
improving
effectiveness
chemotherapy,
targeted
therapy,
immunotherapy.
future,
developing
novel
target
fibrotic
microenvironment,
new
therapeutic
options
may
be
available
patients
various
refractory
tumors.
Journal of Cancer,
Journal Year:
2024,
Volume and Issue:
16(3), P. 700 - 707
Published: Dec. 31, 2024
Developing
new
drug
delivery
systems
is
crucial
for
enhancing
the
efficacy
of
oncolytic
virus
(OV)
therapies
in
cancer
treatment.
In
this
study,
mesenchymal
stem
cell
(MSC)-derived
vesicles
and
viruses
are
exploited
to
construct
a
novel
formulation.
It
has
been
hypothesized
that
vesicle-coated
OVs
could
amplify
cytotoxic
effects
through
superior
internalization
by
tumor
cells.
MSC
possess
natural
homing
ability
biocompatibility,
which
can
enhance
targeting,
uptake,
therapeutic
on
Experimental
results
indicated
treatment
system
increased
apoptosis
Furthermore,
flow
cytometry
analysis
demonstrated
uptake
cells
coated
with
soared
away
compared
uncoated
OVs,
being
1.5
times
than
group.
Additionally,
confocal
laser
scanning
microscopy
also
showed
fluorescence
intensity
within
pretreated
MSC-coated
was
greater.
Meanwhile,
propidium
iodide
(PI)
staining
revealed
Ovs
exposed
accelerating
latter.
According
statistics,
number
dead
increased,
testified
OV
group
as
high
23.78%.
These
findings
highlight
potential
therapy,
providing
promising
strategy
