Role of long non-coding RNAs in the regulation of ferroptosis in tumors DOI Creative Commons

Ying Ju,

Yuanhao Lv,

Xu Liu

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: March 21, 2025

Normal cells begin to grow indefinitely and immortalize form tumor after an external stimulus resulting in a genetic mutation. Effective killing of is the basis various cancer therapies. Ferroptosis class cell death types dependent on iron cellular lipid peroxidation. Tumors themselves are iron-dependent, conventional radiotherapy also sensitizes ferroptosis. Increasing sensitivity ferroptosis may be potential therapeutic strategy overcome resistance mechanisms therapy. Long noncoding RNAs (LncRNAs) transcripts more than 200 nucleotides length that regulate gene expression at multiple levels involved biological processes such as differentiation, cycle arrest, maintenance stemness. Recent studies have found lncRNAs through influence or ameliorate chemotherapeutic agents. With continuous maturation nanomaterials technology, it provide new means for treatment by regulating ferroptosis-related inside tumors well increasing Fe 2+ ROS tumors. In this paper, we systematically introduce regulatory mechanism ferroptosis, role immunotherapy application combined with nanomaterials, which provides perspectives

Language: Английский

Overcoming immunotherapy resistance in gastric cancer: insights into mechanisms and emerging strategies DOI Creative Commons

D.Y. Luo,

Jing Zhou, Shuiliang Ruan

et al.

Cell Death and Disease, Journal Year: 2025, Volume and Issue: 16(1)

Published: Feb. 7, 2025

Abstract Gastric cancer (GC) remains a leading cause of cancer-related mortality worldwide, with limited treatment options in advanced stages. Immunotherapy, particularly immune checkpoint inhibitors (ICIs) targeting PD1/PD-L1, has emerged as promising therapeutic approach. However, significant proportion patients exhibit primary or acquired resistance, limiting the overall efficacy immunotherapy. This review provides comprehensive analysis mechanisms underlying immunotherapy resistance GC, including role tumor microenvironment, dynamic PD-L1 expression, compensatory activation other checkpoints, and genomic instability. Furthermore, explores GC-specific factors such molecular subtypes, unique evasion mechanisms, impact Helicobacter pylori infection. We also discuss emerging strategies to overcome combination therapies, novel immunotherapeutic approaches, personalized based on genomics microenvironment. By highlighting these key areas, this aims inform future research directions clinical practice, ultimately improving outcomes for GC undergoing

Language: Английский

Citations

6
Predicting immunotherapy efficacy in endometrial cancer: focus on the tumor microenvironment DOI Creative Commons
Л. А. Таширева, Irina Larionova, N. A. Ermak

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 20, 2025

Immunotherapy represents a groundbreaking therapeutic approach, based on the immune system’s intrinsic capacity to interfere with tumor progression, that opens horizons in treatment of endometrial cancer. However, clinical efficacy immunotherapy is hampered by development resistance patients. The multifactorial mechanism, encompassed genetic and epigenetic alterations cells modulating checkpoint molecules, resulted escaping surveillance. microenvironment can orchestrate an immunosuppressive milieu, attenuating response facilitating progression. To overcome immunotherapeutic cancer we must bring light mechanisms intricate interplay between neoplastic cells, host system, microenvironment. identification predictive biomarkers for innovative agents capable reversing pathways be developed. Our review summarizes accumulated data role their regulatory molecules underlying effects inhibitors, including therapy. Major question raise here – which group patients most favorable achieve durable cancer?

Language: Английский

Citations

3
Nanomedicines Targeting Metabolic Pathways in the Tumor Microenvironment: Future Perspectives and the Role of AI DOI Creative Commons

Shuai Fan,

Wenyu Wang,

Wieqi Che

et al.

Metabolites, Journal Year: 2025, Volume and Issue: 15(3), P. 201 - 201

Published: March 13, 2025

Background: Tumor cells engage in continuous self-replication by utilizing a large number of resources and capabilities, typically within an aberrant metabolic regulatory network to meet their own demands. This dysregulation leads the formation tumor microenvironment (TME) most solid tumors. Nanomedicines, due unique physicochemical properties, can achieve passive targeting certain tumors through enhanced permeability retention (EPR) effect, or active deliberate design optimization, resulting accumulation TME. The use nanomedicines target critical pathways holds significant promise. However, requires careful selection relevant drugs materials, taking into account multiple factors. traditional trial-and-error process is relatively inefficient. Artificial intelligence (AI) integrate big data evaluate delivery efficiency nanomedicines, thereby assisting nanodrugs. Methods: We have conducted detailed review key papers from databases, such as ScienceDirect, Scopus, Wiley, Web Science, PubMed, focusing on reprogramming, mechanisms action development metabolism, application AI empowering nanomedicines. integrated content present current status research metabolism potential future directions this field. Results: Nanomedicines possess excellent TME which be utilized disrupt cells, including glycolysis, lipid amino acid nucleotide metabolism. disruption selective killing disturbance Extensive has demonstrated that AI-driven methodologies revolutionized nanomedicine development, while concurrently enabling precise identification molecular regulators involved oncogenic reprogramming pathways, catalyzing transformative innovations targeted cancer therapeutics. Conclusions: great Additionally, will accelerate discovery metabolism-related targets, empower optimization help minimize toxicity, providing new paradigm for development.

Language: Английский

Citations

2
Functional nanoplatform for modulating cellular forces to enhance antitumor immunity via mechanotransduction DOI
Wanheng Zhang, Shuqin Liu,

Yan Hou

et al.

Journal of Controlled Release, Journal Year: 2025, Volume and Issue: 379, P. 850 - 865

Published: Jan. 29, 2025

Language: Английский

Citations

1
Microbially synthesized nanomaterials: Advances and applications in biomedicine DOI Creative Commons
Junjie Pan, Hong Qian, Ya‐Yen Sun

et al.

Precision medicine and engineering., Journal Year: 2025, Volume and Issue: unknown, P. 100019 - 100019

Published: Feb. 1, 2025

Language: Английский

Citations

1
Hydrotalcites-Induced Pyroptosis Combined with Toll-Like Receptor Activation Elicited Dual Stimulation of Innate and Adaptive Immunity DOI
Jie Wu, Zhicheng Liu, Li Wang

et al.

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 18, 2025

Increasing evidence illustrates the significance of promoting tumor immunogenicity and an efficient immune response in immunotherapy, but immunosuppressive microenvironment (TME) remains obstacle. Herein, AlZn hydrotalcite (AZOH) was synthesized as a pyroptosis inducer further loaded with R848 to formulate R@AZOH. R@AZOH efficiently triggered CT26 cell through Zn2+ overload-evoked mitochondrial dysfunction its downstream caspase-1/GSDMD pathway, resulting release inflammatory cytokines, membrane fracture, immunogenic death (ICD). Moreover, served antigen traps facilitate presentation, thereby cooperating TLR activation dually stimulate dendritic cells (DCs). The combination rapidly initiated innate immunity prolonged adaptive response, suppression growth, "hot" niche. potent antitumor enhanced by checkpoint inhibitor (αCTLA-4), which inhibited both primary distant tumors, well systemic activation. Astonishingly, we also explored potential application vaccine adjuvant demonstrated ability elicit immunological memory prevent growth orthotopic melanoma model. Overall, our work emphasized combining overcome TME presented good candidate.

Language: Английский

Citations

1
Applications and challenges of immunotherapy in the management of gastric adenocarcinoma: current status and future perspectives DOI Creative Commons
Zhiyao Chen,

Yunbin Ma,

Jianan Chen

et al.

World Journal of Surgical Oncology, Journal Year: 2025, Volume and Issue: 23(1)

Published: March 19, 2025

Gastric adenocarcinoma (GAC) remains a significant global public health challenge, characterized by high incidence and mortality rates. Progress in tumor immunology has introduced immune checkpoint inhibitors (ICIs) targeting the programmed cell death-1 (PD-1)/programmed death-ligand 1 (PD-L1) cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) pathways, demonstrating substantial potential GAC therapy. Clinical research indicates that ICIs, particularly when combined with chemotherapy or targeted therapies, significantly enhance treatment efficacy advanced specific molecular subtypes, including microsatellite instability-high (MSI-H) human epidermal growth factor receptor 2 (HER2)-positive patients. However, immunotherapy is also associated range of immune-related adverse events (irAEs), necessitating effective management strategies to ensure safety maintain patients' quality life. Future studies should focus on identifying new therapeutic targets, optimizing patient selection, developing personalized approaches further improve GAC.

Language: Английский

Citations

1
The influence of endothelial metabolic reprogramming on the tumor microenvironment DOI Creative Commons

Kelby M. Kane,

Deanna N. Edwards, Jin Chen

et al.

Oncogene, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 20, 2024

Abstract Endothelial cells (ECs) that line blood vessels act as gatekeepers and shape the metabolic environment of every organ system. In normal conditions, endothelial are relatively quiescent with organ-specific expression signatures profiles. cancer, ECs metabolically reprogrammed to promote formation new fuel tumor growth metastasis. addition EC’s role on cells, tortuous vasculature contributes an immunosuppressive by limiting T lymphocyte infiltration activity while also promoting recruitment other accessory pro-angiogenic immune cells. These elements aid in metastatic spreading cancer contribute therapeutic resistance. The concept restoring a more stabilized concert immunotherapy is emerging potential approach overcoming barriers treatment. This review summarizes metabolism their regulation nutrient uptake delivery, impact shaping microenvironment anti-tumor immunity. We highlight approaches target harness response. Appreciating integration state levels crosstalk among TME may provide avenues for intervention.

Language: Английский

Citations

7
OSBPL3 modulates the immunosuppressive microenvironment and predicts therapeutic outcomes in pancreatic cancer DOI Creative Commons
Qihui Sun, Xiaoqi Zhu, Qi Zou

et al.

Biology Direct, Journal Year: 2025, Volume and Issue: 20(1)

Published: Jan. 9, 2025

Language: Английский

Citations

1
Revolutionizing cancer treatment: The power of dendritic cell-based vaccines in immunotherapy DOI Open Access
Mohsen Sheykhhasan, Amirhossein Ahmadieh-Yazdi, Reza Heidari

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2025, Volume and Issue: 184, P. 117858 - 117858

Published: Feb. 16, 2025

Language: Английский

Citations

1