Journal of Health Sciences and Medicine,
Journal Year:
2025,
Volume and Issue:
8(3), P. 389 - 394
Published: May 30, 2025
Aims:
The
aim
of
this
study
is
to
investigate
the
effects
68Ga,
18F,
89Sr,
13N,
133Xe
and
131I
radionuclide
sources
on
organ
doses
effective
at
different
distances.
Methods:
In
study,
radionuclides
commonly
used
in
nuclear
medicine
applications
were
defined
VMC
dose
calculation
software
determine
values
varying
Additionally,
rates
each
obtained
using
Rad
pro
calculator
online
program.
Results:
For
a
10
mCi
dose,
average
rate
measurements
conducted
Specifically,
13N
89Sr
delivered
highest
certain
organs,
whereas
ve
resulted
lower
doses.
100
cm
for
determined
be
2.72
µSv,
2.94
2.50
2.84
0.91
1.16
respectively.
150
1.56
1.49
1.30
1.46
0.14
0.58
As
distance
increased,
radiation
exposure
levels
decreased.
Conclusion:
decreased
significantly
with
from
source,
demonstrating
importance
maintaining
applying
ALARA
principles
clinical
settings.
Furthermore,
avoiding
close
proximity
source
utilizing
appropriate
shielding
methods
are
crucial
minimizing
exposure.
Journal of Labelled Compounds and Radiopharmaceuticals,
Journal Year:
2025,
Volume and Issue:
68(1-2)
Published: Jan. 1, 2025
Poly
(ADP-ribose)
polymerase
1
(PARP1)
plays
critical
roles
in
DNA
repair,
chromatin
regulation,
and
cellular
equilibrium,
positioning
it
as
a
pivotal
target
for
therapeutic
interventions
cancer
central
nervous
system
(CNS)
disorders.
PARP1
responds
to
oxidative
stress
damage
through
PARylation,
influencing
energy
depletion,
survival,
inflammation,
genomic
regulation
many
biological
scenarios.
PARP
inhibitors
(PARPis)
have
demonstrated
efficacy
against
cancers
harboring
defective
homologous
recombination
repair
pathways,
notably
those
linked
BRCA
mutations.
PARP1-targeted
PET
imaging
enables
patient
stratification,
treatment
assessment,
PARPi
pharmacodynamic
evaluation
other
pathophysiological
conditions.
Importantly,
theranostics
emerged
both
diagnostic
applications
multiple
types
of
cancers,
representing
advancement
personalized
oncology.
However,
its
application
brain
tumors
is
limited
by
the
heterogeneous
integrity
blood
barrier
(BBB)
blood-tumor
barrier.
Thus,
development
BBB-penetrant
tracers
remains
an
unmet
need
cancers.
This
review
summarizes
current
landscape
radiopharmaceuticals
radioligands
targeting
PARP1,
detailing
their
pharmacological
characteristics
potential
clinical
uses.
Furthermore,
this
discusses
that
can
cross
BBB,
underscoring
neurooncology
neurological
Electronics,
Journal Year:
2025,
Volume and Issue:
14(7), P. 1441 - 1441
Published: April 2, 2025
Positron
emission
tomography
(PET)
is
one
of
the
most
advanced
imaging
diagnostic
devices
in
medical
field,
playing
a
crucial
role
tumor
diagnosis
and
treatment.
However,
patient
motion
during
scanning
can
lead
to
artifacts,
which
affect
accuracy.
This
study
aims
develop
head
monitoring
system
identify
select
images
with
excessive
corresponding
periods.
The
system,
based
on
an
RGB-D
structured-light
camera,
implements
facial
feature
point
detection,
3D
information
acquisition,
monitoring,
along
user
interaction
software.
Through
phantom
experiments
volunteer
experiments,
system’s
performance
was
tested
under
various
conditions,
including
stillness,
pitch
movement,
yaw
comprehensive
movement.
Experimental
results
show
that
translational
error
less
than
2.5
mm,
rotational
2.0°,
it
output
within
10
s
after
PET
scanning,
meeting
clinical
accuracy
requirements
showing
significant
potential
for
application.
Brazilian Journal of Radiation Sciences,
Journal Year:
2025,
Volume and Issue:
12(4A (Suppl.)), P. e2812 - e2812
Published: April 28, 2025
Positron
emission
tomography
(PET)
is
an
important
tool
in
preclinical
studies
small
animals,
providing
real-time
insights
into
biochemical,
metabolic,
physiological,
and
functional
processes.
PET
imaging
also
enables
the
assessment
of
biological
responses
biodistribution
novel
radiolabeled
compounds
within
a
single
animal,
minimizing
need
for
larger
animal
groups.
In
particular,
with
[18F]DPA-714,
Translocator
Protein
(TSPO)
ligand,
has
shown
high
predictive
prognostic
value
diseases
associated
neuroinflammation
correlates
well
outcomes.
this
study,
basal
expression
TSPO
was
investigated
vivo
C57BL/6
mice
proposed
as
method
to
track
new
molecules.
Male
aged
6–9
weeks
weighing
20–30
g
were
divided
healthy
ischemic
The
group
subjected
transient
global
cerebral
ischemia
induced
by
25
min
bilateral
common
carotid
artery
occlusion
(BCCAO)
followed
reperfusion.
Baseline
[18F]DPA-714
performed
static
whole-body
scans
at
0-20,
20-40,
40-60,
60-80
post-injection
intervals.
After
ischemia,
used
examine
uptake
[18F]DPA-714.
results
confirm
that
effective,
non-invasive
technique
studies.
Analysis
SUVmean,
SUVmax,
SUVpeak
metrics
showed
increased
sensitivity
brain
following
highlighting
its
importance
models.
Furthermore,
baseline
observed
multiple
organs,
reflecting
metabolic
clearance
pathways.
comparable
muscle
underscores
potential
reliable
marker
studying
TSPO-related
inflammatory
