Tumor Microenvironment Lactate: Is It a Cancer Progression Marker, Immunosuppressant, and Therapeutic Target? DOI Creative Commons
Eugene Y. Kim,

Joyce Abides,

Chandler R. Keller

et al.

Molecules, Journal Year: 2025, Volume and Issue: 30(8), P. 1763 - 1763

Published: April 15, 2025

The “Warburg effect” is a term coined century ago for the preferential use of glycolysis over aerobic respiration in tumor cells energy production, even under conditions. Although this less efficient mechanism generating from glucose, glycolysis, addition to canonical anaerobic an effective means lactate production. abundant waste product, lactate, yielded by dual tumor, has been discovered be major biomolecule that drives cancer progression. Lactate metabolic source that, via cell membrane transporters, shuttles and out as well cell-associated stromal immune within microenvironment (TME). Additionally, serves pH tuner, signaling ligand transducer, epigenetic gene transcription regulator, TME modifier, suppressor, chemoresistance modulator, prognostic marker. With such broad functionalities, production–consumption–reproduction fuels growth dissemination. Here, we elaborate on sources contribute pool TME, functions influence function local tissue immunity, anticancer therapeutic approaches adopting manipulations their efficacies. By scrutinizing these properties others have addressed field, it expected better weighing development, progression, prognosis, efficacy can achieved.

Language: Английский

Special Issue “Cancer Biomarker: Current Status and Future Perspectives” DOI Open Access
Susan Costantini

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(5), P. 2164 - 2164

Published: Feb. 28, 2025

In recent years, advancements in omics technologies have significantly accelerated the identification of a broad spectrum biomarkers based on DNA, RNA, microRNAs (miRNAs), and long non-coding RNAs, as well proteins metabolic lipid alterations (Figure 1) [...].

Language: Английский

Citations

0
Pain, lactate, and anesthetics: intertwined regulators of tumor metabolism and immunity DOI Creative Commons
Qing Lan, Aiping Ouyang, Yijian Chen

et al.

Frontiers in Oncology, Journal Year: 2025, Volume and Issue: 15

Published: March 17, 2025

Patients with advanced cancer frequently endure severe pain, which substantially diminishes their quality of life and can adversely impact survival. Analgesia, a critical modality for alleviating such is now under scrutiny its potential role in progression, relationship whose underlying mechanisms remain obscure. Emerging evidence suggests that lactate, once considered metabolic byproduct, actively participates the malignant progression by modulating both immunological pathways within tumor microenvironment. Furthermore, lactate implicated modulation cancer-related exerting effects through direct indirect mechanisms. This review synthesizes current understanding lactate's production, transport, functional roles cells, encompassing regulation metabolism, immunity, progression. Additionally, we dissect complex, bidirectional between assess anesthetics on pain relief, homeostasis, tumorigenesis.

Language: Английский

Citations

0
Potential role of lactylation in intrinsic immune pathways in lung cancer DOI Creative Commons

Mengdie Huang,

Ye Jin, Dandan Zhao

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: March 17, 2025

Lung cancer, one of the most lethal malignancies, has seen its therapeutic strategies become a focal point significant scientific attention. Intrinsic immune signaling pathways play crucial roles in anti-tumor immunity but face clinical application challenges despite promising preclinical outcomes. Lactylation, an emerging research focus, may influences lung cancer progression by modulating functions histones and non-histone proteins. Recent findings have suggested that lactylation regulates key intrinsic molecules, including cGAS-STING, TLR, RIG-I, thereby impacting interferon expression. However, precise mechanisms which governs remain unclear. This review presents comprehensive systematic analysis relationship between emphasizes innovative perspective linking lactylation-mediated epigenetic modifications with regulation. By thoroughly examining current findings, this uncovers potential regulatory highlights implications targeting cancer. Future investigations into intricate interactions are anticipated to unveil novel targets strategies, potentially improving patient survival

Language: Английский

Citations

0
A novel lactylation-related signature predicts the prognosis and is associated with immune infiltration in thyroid cancer DOI Creative Commons
Baoqing Liu,

Mengxia Zheng,

Jianhua Liao

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: March 20, 2025

Abstract Background​: Epigenetic regulator lactate, a glycolysis product, affects gene expression via histone lactylation, promoting tumor growth and immunosuppression. But its related genes' role in thyroid carcinoma (THCA) remains unclear.​ Methods​: Lactylation - genes from TCGA were consensus clustered. DEGs between clusters analyzed Cox regression, Random_forest, LASSO to create Lactylation High/Low risk signature. data was split for validation. Immune cell infiltration, GSEA, TIDE score drug sensitivity of the subtypes examined. A lactylation scoring model built as per prior method, lactate levels "Two risk" cluster" compared. Signature detected THCA GSE33630 datasets. Results​: Ten formed 2 prognostic valuable (p = 0.01) THCA. 137 identified these clusters. 7 signature (High Low risk) showed significant survival correlation < 0.001). infiltration GSEA analysis higher immune activity low group. The Exclusion suggested escape high nomogram including established prediction. Cluster B High group had poor prognoses. linked score, indicating more escape. Validation samples CLDN2, ARSI, SPOCD1, TUBB3 ATP2C2 expression. In conclusions​, the can not only serve marker (THCA), but may also provide new therapeutic targets it. Future studies should further validate potential this clinical application.

Language: Английский

Citations

0
The Warburg effect: the hacked mitochondrial-nuclear communication in cancer DOI
Haowen Jiang, Jiangbin Ye

Seminars in Cancer Biology, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Citations

0
Metabolic Reprogramming of Tumor Microenviroment by Engineered Bacteria DOI
Heng Wang, Fang Xu, Chao Wang

et al.

Seminars in Cancer Biology, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Citations

0
Integrated multi-omics analysis reveals the functional and prognostic significance of lactylation-related gene PRDX1 in breast cancer DOI Creative Commons

Qinqing Wu,

Heng Cao,

J. Jin

et al.

Frontiers in Molecular Biosciences, Journal Year: 2025, Volume and Issue: 12

Published: April 4, 2025

Background Breast cancer (BRCA) is a significant threat to women’s health worldwide, and its progression closely associated with the tumor microenvironment gene regulation. Lactylation modification, as key epigenetic mechanism in biology, has not yet been fully elucidated context of BRCA. This study examines regulatory mechanisms lactylation-related genes (LRGs), specifically PRDX1, their prognostic significance Methods We integrated data from multiple databases, including Genome-Wide Association Study (GWAS) summary statistics, single-cell RNA sequencing, spatial transcriptomics, bulk sequencing The Cancer Genome Atlas (TCGA) Gene Expression Omnibus (GEO) databases. Using Summary-based Mendelian Randomization (SMR) analysis, we identified LRGs BRCA comprehensively analysed expression patterns cell-cell communication networks, heterogeneity. Furthermore, constructed validated model based on profile PRDX1-positive monocytes, evaluating it through Cox regression LASSO analyses. Results PRDX1 was LRG significantly risk (p_SMR = 0.0026). Single-cell analysis revealed upregulation enhanced between monocytes fibroblasts. Spatial transcriptomics uncovered heterogeneous nest regions, highlighting interaction demonstrated high accuracy predicting patient survival both training validation cohorts. High-risk patients exhibited immune-suppressive characteristics, reduced immune cell infiltration checkpoint expression. Conclusion reveals role progression, mainly regulation escape mechanisms. prediction shows robust potential, future research should focus integrating other biomarkers enhance precision personalised medicine.

Language: Английский

Citations

0
RNA methyltransferase METTL16: from molecular mechanisms to therapeutic prospects in cancers DOI

Zhuozheng Shi,

Xiankui Cao,

Yiming Ma

et al.

Cancer Letters, Journal Year: 2025, Volume and Issue: unknown, P. 217698 - 217698

Published: April 1, 2025

Language: Английский

Citations

0
Tumor Microenvironment Lactate: Is It a Cancer Progression Marker, Immunosuppressant, and Therapeutic Target? DOI Creative Commons
Eugene Y. Kim,

Joyce Abides,

Chandler R. Keller

et al.

Molecules, Journal Year: 2025, Volume and Issue: 30(8), P. 1763 - 1763

Published: April 15, 2025

The “Warburg effect” is a term coined century ago for the preferential use of glycolysis over aerobic respiration in tumor cells energy production, even under conditions. Although this less efficient mechanism generating from glucose, glycolysis, addition to canonical anaerobic an effective means lactate production. abundant waste product, lactate, yielded by dual tumor, has been discovered be major biomolecule that drives cancer progression. Lactate metabolic source that, via cell membrane transporters, shuttles and out as well cell-associated stromal immune within microenvironment (TME). Additionally, serves pH tuner, signaling ligand transducer, epigenetic gene transcription regulator, TME modifier, suppressor, chemoresistance modulator, prognostic marker. With such broad functionalities, production–consumption–reproduction fuels growth dissemination. Here, we elaborate on sources contribute pool TME, functions influence function local tissue immunity, anticancer therapeutic approaches adopting manipulations their efficacies. By scrutinizing these properties others have addressed field, it expected better weighing development, progression, prognosis, efficacy can achieved.

Language: Английский

Citations

0