Neomycin affects cardiovascular and hematopoietic system via the PI3K/Akt pathway in zebrafish larvae

Ecotoxicology and Environmental Safety, Journal Year: 2025, Volume and Issue: 296, P. 118203 - 118203

Published: April 21, 2025

Language: Английский

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Bioinspired Claw‐Engaged Adhesive Microparticles Armed with γGC Alleviate Ulcerative Colitis via Targeted Suppression of Macrophage Ferroptosis

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: April 29, 2025

Abstract Ulcerative colitis (UC) is a chronic inflammatory bowel disease, characterized by focal iron overload. Herein, we reported that γ‐glutamylcysteine (γGC) deletion in UC lesions intensified the disease depleting intracellular GSH to induce macrophage ferroptosis, leading M1 reprogramming and eventually exacerbating inflammation. To counteract this, advanced microparticles (MPs)‐based delivery system selected encapsulate γGC. The resulting γGC‐MPs displayed same porous spiky morphology as their substrate's natural pollens, improved intestinal adhesion enhanced lesion contact of γGC‐MPs. Our results demonstrated exogenous γGC supplementation could inhibit polarization restraining well suppressing PI3K/AKT pathway TNF signaling pathway. Compared with free γGC, significantly alleviated typical symptoms dextran sulfate sodium (DSS)‐induced colitis, evidenced reduced inflammation, restored barrier function, microbiota composition. Consequently, this study addressed critical gaps understanding causes ferroptosis its impact on UC, offering novel synergistic therapeutic strategy for UC.

Language: Английский

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Targeting mitochondria with natural polyphenols for treating Neurodegenerative Diseases: a comprehensive scoping review from oxidative stress perspective

Journal of Translational Medicine, Journal Year: 2025, Volume and Issue: 23(1)

Published: May 23, 2025

Neurodegenerative diseases are a class of conditions with widespread detrimental impacts, currently lacking effective therapeutic drugs. Recent studies have identified mitochondrial dysfunction and the resultant oxidative stress as crucial contributors to pathogenesis neurodegenerative diseases. Polyphenols, naturally occurring compounds inherent antioxidant properties, demonstrated potential target mitochondria mitigate stress. This has garnered significant attention in recent years. Investigating targeting capacity polyphenols, their role functional regulation, ability modulate stress, along exploring novel technologies strategies for modifying polyphenol formulations, holds promise providing new avenues treatment

Language: Английский

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Ablation of Mouse Selenium-Binding Protein 1 and 2 Elevates LDL by Disruption of Cholesterol Efflux and Lipid Metabolism

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(7), P. 3363 - 3363

Published: April 3, 2025

Selenium-binding protein 1 (SeBP1) is an anticancer factor that affects lipid metabolism in mouse kidneys via the peroxisome proliferator-activated receptor-alpha (PPARA) pathway. However, its physiological role liver difficult to explain because of presence highly homologous selenium-binding 2 (SeBP2). To investigate these proteins liver, we generated SeBP1 and SeBP2 double-knockout mice (SeBP1/2-DK). SeBP1/2 deletion did not significantly alter phenotypic compared wild-type strain. Then, identified genes involved hepatic metabolism. The double knockout affect fatty acid cholesterol synthesis, but inhibited oxidation efflux. Furthermore, transfection HepG2 cells with human (hSeBP1) positively regulated PPARA controlled by it. Overexpression hSeBP1 reduced levels non-esterified acids culture medium. serum low-density lipoprotein cholesterol, high-density triglycerides were different among three groups. In summary, elucidated potential signaling pathways Our findings provide insights relevant for developing new strategies prevent treat disorders.

Language: Английский

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Rebalancing redox homeostasis: A pivotal regulator of the cGAS-STING pathway in autoimmune diseases

Autoimmunity Reviews, Journal Year: 2025, Volume and Issue: 24(6), P. 103823 - 103823

Published: April 24, 2025

Language: Английский

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Hyperuricemia: current insights into pathogenesis, association with chronic kidney disease, oxidative stress, and perspectives of antioxidant therapy

Likarska sprava, Journal Year: 2025, Volume and Issue: 2

Published: May 26, 2025

Hyperuricemia (HUr) is not only a consequence of impaired purine metabolism but also an independent risk factor for the development and progression chronic kidney disease (CKD). This article provides systematic review current pathophysiological mechanisms renal tissue damage in HUr, particularly activation oxidative stress, inflammatory cascades, endothelial dysfunction, fibrosis development. Special attention given to uromodulin (Umod) as biomarker tubular system potential mediator nephropathological processes. The reviews literature on therapeutic antioxidants, particular glutathione ubiquinone, context pathogenetically targeted therapy CKD associated with hyperuricemia. based sources published between 2021 2025 does include primary results from authors’ own clinical observations. Conclusions: In CKD, hyperuricemia requires multifactorial diagnostic approach, taking into account role stress prospects antioxidant therapy.

Language: Английский

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Redox-signaling in innate immune memory: Similar mechanisms in animals and plants

Redox Biology, Journal Year: 2025, Volume and Issue: unknown, P. 103702 - 103702

Published: May 1, 2025

Language: Английский

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