Genetic Profiling of Acute and Chronic Leukemia via Next-Generation Sequencing: Current Insights and Future Perspectives

Hematology Reports, Journal Year: 2025, Volume and Issue: 17(2), P. 18 - 18

Published: March 28, 2025

Leukemia is a heterogeneous group of hematologic malignancies characterized by distinct genetic and molecular abnormalities. Advancements in genomic technologies have significantly transformed the diagnosis, prognosis, treatment strategies for leukemia. Among these, next-generation sequencing (NGS) has emerged as powerful tool, enabling high-resolution profiling that surpasses conventional diagnostic approaches. By providing comprehensive insights into mutations, clonal evolution, resistance mechanisms, NGS revolutionized precision medicine leukemia management. Despite its transformative potential, clinical integration presents challenges, including data interpretation complexities, standardization issues, cost considerations. However, continuous advancements platforms bioinformatics pipelines are enhancing reliability accessibility routine practice. The expanding role paving way improved risk stratification, targeted therapies, real-time disease monitoring, ultimately leading to better patient outcomes. This review highlights impact on research applications, discussing advantages over traditional techniques, key approaches, emerging challenges. As oncology continues evolve, expected play an increasingly central diagnosis management leukemia, driving innovations personalized therapeutic interventions.

Language: Английский

The Role of Epithelial–Mesenchymal Transition in Malignant Pleural Mesothelioma: From Pathogenesis to Diagnosis and Treatment

Cells, Journal Year: 2025, Volume and Issue: 14(8), P. 585 - 585

Published: April 12, 2025

Malignant pleural mesothelioma (MPM) is an aggressive cancer of the lining, primarily associated with asbestos exposure. Despite advancements in multimodal treatment, patient survival remains poor. Epithelial–mesenchymal transition (EMT) has emerged as a crucial process driving MPM pathogenesis, metastasis, and resistance to therapy. This review explores molecular mechanisms underlying EMT MPM, including key signaling pathways such TGF-β, Wnt/β-catenin, PI3K/Akt. We also discuss diagnostic prognostic significance EMT-related biomarkers emerging targeted therapies aimed at reversing or exploiting EMT-induced vulnerabilities. Additionally, recent clinical trials, MARS 2 trial, are reviewed provide insight into evolving treatment landscape.

Language: Английский

4′-hydroxywogonin inhibits oral squamous cell carcinoma progression by targeting Gas6/Axl signaling axis

Journal of Dental Sciences, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский