European Journal of Pharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 177808 - 177808
Published: June 1, 2025
Language: Английский
ACS Medicinal Chemistry Letters, Journal Year: 2025, Volume and Issue: unknown
Published: April 1, 2025
Provided herein are novel piperidinylpyridinylcarbonitrile derivatives as QPCT and QPCTL inhibitors, pharmaceutical compositions, use of such compounds in treating cancer, processes for preparing compounds.
Language: Английский
Citations
1
ACS Medicinal Chemistry Letters, Journal Year: 2025, Volume and Issue: unknown
Published: April 14, 2025
Provided herein are novel piperidinylpyridinylcarbonitrile derivatives as QPCT and QPCTL inhibitors, pharmaceutical compositions, use of such compounds in treating cancer, processes for preparing compounds.
Language: Английский
Citations
0
Forests, Journal Year: 2025, Volume and Issue: 16(5), P. 737 - 737
Published: April 25, 2025
Torreya grandis kernels, with their long cultivation history and significant economic value, have gained attention for characteristic chemical components. This review systematically evaluates recent research on the constituents biological activities of T. kernels. The key highlights include following. (1) Chemical composition: details unique fatty acid profile, particularly high content unsaturated acids rare polymethylene-interrupted polyunsaturated such as sciadonic acid. It also examines polyphenolic compounds (flavonoids, phenolic acids, biflavonoids like kayaflavone) volatile components dominated by D-limonene. Other constituents, proteins, amino vitamins, minerals, are covered. Advanced analytical techniques (Gas Chromatography–Mass Spectrometry, GC-MS; Liquid Chromatography–Tandem Mass LC-MS/MS) component identification discussed. (2) Biological activities: summarizes major kernel extracts These antioxidant effects (via polyphenol-mediated NF-E2-related factor 2 (Nrf2) pathway), anti-inflammatory properties PMI-PUFAs, inhibition 5-LOX, polyphenol regulation NF-κB), cardiovascular protection (potentially involving AMPKα/SREBP-1c pathway). Research gut microbiota enzyme is outlined. (3) gaps prospects: critically analyzes limitations in current research, including mechanism elucidation, interactions, bioavailability, safety assessment (especially lack human studies). Future directions should focus multiomics integration, structure–activity relationship analysis, standardization, rigorous clinical evaluation. provides a theoretical reference understanding scientific value kernels promoting sustainable development.
Language: Английский
Citations
0
Advanced Fiber Materials, Journal Year: 2025, Volume and Issue: unknown
Published: May 2, 2025
Language: Английский
Citations
0
Cells, Journal Year: 2025, Volume and Issue: 14(10), P. 741 - 741
Published: May 19, 2025
Tumor-associated macrophages’ (TAMs) origin, polarization, and dynamic interaction in the tumor microenvironment (TME) influence cancer development. They are essential for homeostasis, monitoring, immune protection. Cells from bone marrow or embryonic progenitors dynamically polarize into pro- anti-tumor M2 M1 phenotypes based on cytokines metabolic signals. Recent advances TAM heterogeneity, characterization, immunological responses, therapy described here. The manuscript details functions their role resistance to PD-1/PD-L1 blockade. Similarly, TAM-targeted approaches, such as CSF-1R inhibition PI3Kγ-driven reprogramming, discussed address immunity suppression. Furthermore, innovative biomarkers combination may enhance TAM-centric therapies. It also stresses relevance of this distinct cell human health disease, which could impact future research
Language: Английский
Citations
0
Immunology, Journal Year: 2025, Volume and Issue: unknown
Published: May 21, 2025
ABSTRACT Macrophages play a critical role in shaping the immune landscape of various diseases, with secreted phosphoprotein 1 (SPP1)‐expressing macrophages emerging as distinct subset implicated both cancerous and non‐cancerous conditions. Leveraging recent advances single‐cell RNA sequencing, numerous studies have identified SPP1 + across diverse pathological contexts, shedding light on their functional heterogeneity. In cancer, tumour‐associated contribute to tumour growth, angiogenesis, evasion, often interacting T cells stromal components sustain an immunosuppressive microenvironment. Conversely, these exhibit profibrotic disease‐promoting properties, depending tissue context. This review provides comprehensive synthesis latest findings macrophages, highlighting roles progression, suppression, remodelling, fibrosis. By comparing shared traits tissue‐specific differences, we explore how adapt microenvironments influence disease progression. Understanding conserved context‐dependent functions may open new avenues for therapeutic targeting.
Language: Английский
Citations
0
Cell Communication and Signaling, Journal Year: 2025, Volume and Issue: 23(1)
Published: June 2, 2025
The advent of the omics era has facilitated identification precise biomarkers for cancer progression, revealing a broader diversity macrophage phenotypes beyond traditional M1/M2 classification. Folate receptor 2 (FOLR2)-positive macrophages, co-expressing markers such as mannose C-Type 1 (MRC1/CD206) and lymphatic vessel endothelial hyaluronan 1(LYVE1), are an embryonically derived subset typically found around blood vessels in both tumor stroma normal tissues. Despite FOLR2's longstanding association with anti-inflammatory, immunosuppressive macrophages tumors, its role progression remains unclear. Recent studies suggest that FOLR2+ can either promote or inhibit depending on their multifaceted roles microenvironment. This review provides comprehensive overview biological features, functional roles, molecular mechanisms, therapeutic potential cancer.
Language: Английский
Citations
0
European Journal of Pharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 177808 - 177808
Published: June 1, 2025
Language: Английский
Citations
0